This chapter provides a review of the conceptual and empirical work on HIV prevention specific to Latinas that has developed since Hortensia Amaro's article, "Love, Sex, and Power" was published in The American Psychologist in 1995. At that time, it had become evident that HIV and AIDS were serious epidemics disproportionately affecting Latina women in the United States. The "Love, Sex, and Power" article has been highly cited (462 citations) and has influenced a generation of HIV activists and researchers seeking to provide better guidance and insight into the unique vulnerabilities that women, particularly poor and minority women, face in the context of HIV prevention. Although Amaro's paper addressed the status of HIV/AIDS research among U.S. women in general, many of the author's suggestions have been applicable to HIV/AIDS prevention research with Latina women specifically and provide important conceptual guidelines for future theoretically based, as well as prevention intervention work with Latinas.