Relative frequency of mammary, colonic, rectal, and pancreatic cancer in a large autopsy series. Statistical associations between mortality rates from these cancers: Dietary fat intake as a common aetiological variable
Article
Zaldivar, R, Wetterstrand, WH, Ghai, GL. (1979). Relative frequency of mammary, colonic, rectal, and pancreatic cancer in a large autopsy series. Statistical associations between mortality rates from these cancers: Dietary fat intake as a common aetiological variable
. 169(5-6), 474-481.
Zaldivar, R, Wetterstrand, WH, Ghai, GL. (1979). Relative frequency of mammary, colonic, rectal, and pancreatic cancer in a large autopsy series. Statistical associations between mortality rates from these cancers: Dietary fat intake as a common aetiological variable
. 169(5-6), 474-481.
An investigation on the relative frequency of mammary, colonic, rectal, and pancreatic cancer in a large autopsy sample (N = 15,300) from Greater Santiago (1945-66) was made. In addition, correlation studies between colo-rectal cancers and mammary cancer, between colo-rectal cancers and pancreatic cancer or between malignancies and dietary fat intake were performed. The corrected male, female ratios for mammary, pancreatic, colonic, and rectal were 1:47.28, 1:0.79, 1:0.76 and 1:1.28, respectively. A positive and highly significant correlation between age-adjusted death rates for 100,000 population for cancer of large bowel and death rates for mammary cancer was found in a study involving 23 countries (1962-63). For males, the r(s)-value for colo-rectal cancer rate was + 0.767 (P < 0.00014). For females, the corresponding r(s)-value was + 0.862 (P < 0.00003). When correlation studies were performed between colonic cancer death rates (both sexes combined) and mammary cancer from 12 cities (1962-64), the r(s)-value was + 0.633 (P < 0.018), and between rectal cancer rates (both sexes combined) and mammary cancer, the r(s)-value was + 0.855 (P < 0.0023). Statistically significant associations between male pancreatic cancer and colonic cancer mortality [r(s) = + 0.526; P = 0.041] as well as between male pancreatic cancer rates and rectal cancer mortality [r(s) = + 0.547; P = 0.035] for the 12 cities were detected. Correlations between fat intake and female breast cancer death rates in 39 countries as well as between fat intake and male pancreatic cancer rates in 19 countries showed positive associations. Dietary fat intake appears to be a common etiological variable for colonic, rectal, pancreatic, and mammary cancer.
