Identification and partial characterization of the c-jun oncogene in Xenopus laevis.
Other Scholarly Work
Lazarus, P, Calcagnotto, A. (1994). Identification and partial characterization of the c-jun oncogene in Xenopus laevis.
. CANCER LETTERS, 86(2), 201-208. 10.1016/0304-3835(94)90079-5
Lazarus, P, Calcagnotto, A. (1994). Identification and partial characterization of the c-jun oncogene in Xenopus laevis.
. CANCER LETTERS, 86(2), 201-208. 10.1016/0304-3835(94)90079-5
Sequencing analysis of a 275-nt cDNA fragment encoding the DNA-binding region at the carboxyl terminal of the Xenopus c-jun protein product shows that this region exhibits 77-79% nucleotide homology and 93% amino acid homology with the DNA-binding region of mouse and human c-jun, and contains an intact leucine zipper motif and a basic DNA-binding region. Xenopus c-jun mRNA is induced in quiescent Xenopus A6 kidney cells by 12-O-tetradecanoylphorbol-13-acetate, PDGF and cycloheximide. This 'immediate early' response suggests that Xenopus c-jun may be similar in both structure and function to that observed for its mammalian counterpart.
