Association between haplotypes of manganese superoxide dismutase (SOD2), smoking, and lung cancer risk.
Other Scholarly Work
Gallagher, Carla J, Ahn, Kwangmi, Knipe, Ashley L et al. (2009). Association between haplotypes of manganese superoxide dismutase (SOD2), smoking, and lung cancer risk.
. FREE RADICAL BIOLOGY AND MEDICINE, 46(1), 20-24. 10.1016/j.freeradbiomed.2008.09.018
Gallagher, Carla J, Ahn, Kwangmi, Knipe, Ashley L et al. (2009). Association between haplotypes of manganese superoxide dismutase (SOD2), smoking, and lung cancer risk.
. FREE RADICAL BIOLOGY AND MEDICINE, 46(1), 20-24. 10.1016/j.freeradbiomed.2008.09.018
Tobacco smoke contains high concentrations of reactive oxygen species (ROS) that can damage DNA, proteins, and lipids. Manganese superoxide dismutase (SOD2) catalyzes the dismutation of superoxide radicals into hydrogen peroxide and protects against oxidative stress in lung tissues. Three tagSNPs were identified in one block of high linkage disequilibrium that spans the entire SOD2 gene and 5-kb promoter region. These tagSNPs, representing four haplotypes (TAA, TCA, TCG, CCG), were genotyped in 372 lung cancer cases and 605 controls. There was no association between the haplotype frequencies and the overall lung cancer risk. The TCG haplotype (6% in controls) was significantly associated with a lower risk of lung cancer in light smokers (
