Evidenced cucurbit[: N] uril-based host-guest interactions using single-molecule force spectroscopy
Article
Zhang, M, Zhang, H, Jin, L et al. (2022). Evidenced cucurbit[: N] uril-based host-guest interactions using single-molecule force spectroscopy
. CHEMICAL COMMUNICATIONS, 58(11), 1736-1739. 10.1039/d1cc06791e
Zhang, M, Zhang, H, Jin, L et al. (2022). Evidenced cucurbit[: N] uril-based host-guest interactions using single-molecule force spectroscopy
. CHEMICAL COMMUNICATIONS, 58(11), 1736-1739. 10.1039/d1cc06791e
In this work, enhanced guest-pair interactions in the cavity of cucurbit[8]uril (CB[8]) are quantitatively determined using single-molecule force spectroscopy (SMFS). Significantly, the light-driven dynamic conformational change of guest pairs leads to a rupture force switching between the connected and broken CB[8]-mediated heteroternary complexation with viologen and bis(azobenzene) derivatives. SMFS is further utilized to detect methyl viologen based on the competitive host-guest interaction toward the guest in CB[8] or CB[7]. These findings highlight the extraordinary power of SMFS in supramolecular chemistry and will contribute to the fundamental understanding of the mechanochemical behavior of host-guest interactions.