Improved outcomes of patients with end-stage cystic fibrosis requiring invasive mechanical ventilation for acute respiratory failure Article

Hayes, D, Mansour, HM. (2011). Improved outcomes of patients with end-stage cystic fibrosis requiring invasive mechanical ventilation for acute respiratory failure . LUNG, 189(5), 409-415. 10.1007/s00408-011-9311-6

cited authors

  • Hayes, D; Mansour, HM

authors

abstract

  • Study Objectives The aim of this study was to determine the effects of an antibiotic strategy with intravenous (IV) continuous infusion of a β-lactam (CIBL) antibiotic and high-dose extended-interval (HDEI) tobramycin upon outcomes in patients with cystic fibrosis (CF) requiring invasive mechanical ventilation (IMV) for acute respiratory failure. Design The study was a retrospective review from June 1, 2006, to December 1, 2010, of patients at a university hospital with an adult CF center. Results The study population included adult CF patients requiring IMV. A total of 15 hospitalizations with IMV episodes were reviewed, involving 10 adult (31.4±11.1 years) CF patients with end-stage lung disease (FEV 1 = 23.6±7.8% predicted) and malnutrition (body mass index = 20.5±3.1). Each patient survived to discharge and to follow-up 6 months later without the need for lung transplantation during the study period. Conclusions A novel antibiotic strategy with a CIBL antibiotic and HDEI tobramycin improved survival in a small cohort of critically ill CF patients with end-stage lung disease and malnutrition requiring IMV. © Springer Science+Business Media, LLC 2011.

publication date

  • October 1, 2011

published in

Digital Object Identifier (DOI)

start page

  • 409

end page

  • 415

volume

  • 189

issue

  • 5