CNTF promotes the survival and differentiation of adult spinal cord-derived oligodendrocyte precursor cells in vitro but fails to promote remyelination in vivo Article

Talbott, JF, Cao, Q, Bertram, J et al. (2007). CNTF promotes the survival and differentiation of adult spinal cord-derived oligodendrocyte precursor cells in vitro but fails to promote remyelination in vivo . EXPERIMENTAL NEUROLOGY, 204(1), 485-489. 10.1016/j.expneurol.2006.12.013

cited authors

  • Talbott, JF; Cao, Q; Bertram, J; Nkansah, M; Benton, RL; Lavik, E; Whittemore, SR

authors

abstract

  • Delivery of factors capable of promoting oligodendrocyte precursor cell (OPC) survival and differentiation in vivo is an important therapeutic strategy for a variety of pathologies in which demyelination is a component, including multiple sclerosis and spinal cord injury. Ciliary neurotrophic factor (CNTF) is a neuropoietic cytokine that promotes both survival and maturation of a variety of neuronal and glial cell populations, including oligodendrocytes. Present results suggest that, although CNTF has a potent survival and differentiation promoting effect in vitro on OPCs isolated from the adult spinal cord, CNTF administration in vivo is not sufficient to promote oligodendrocyte remyelination in the glial-depleted environment of unilateral ethidium bromide (EB) lesions. © 2007 Elsevier Inc. All rights reserved.

publication date

  • March 1, 2007

published in

Digital Object Identifier (DOI)

start page

  • 485

end page

  • 489

volume

  • 204

issue

  • 1