Pathogenic mutation in VPS35 impairs its protection against MPP+ cytotoxicity Article

Bi, F, Li, F, Huang, C et al. (2013). Pathogenic mutation in VPS35 impairs its protection against MPP+ cytotoxicity . International Journal of Biological Sciences, 9(2), 149-155. 10.7150/ijbs.5617

cited authors

  • Bi, F; Li, F; Huang, C; Zhou, H

abstract

  • Parkinson's disease primarily results from progressive degeneration of dopaminergic neurons in the substantia nigra. Both neuronal toxicants and genetic factors are suggested to be involved in the disease pathogenesis. The mitochondrial toxicant 1-methyl-4-phenylpyridinium (MPP+) shows a highly selective toxicity to dopaminergic neurons. Recent studies indicate that mutation in the vacuolar protein sorting 35 (vps35) gene segregates with Parkinson's disease in some families, but how mutation in the vps35 gene causes dopaminergic cell death is not known. Here, we report that enhanced VPS35 expression protected dopaminergic cells against MPP+ toxicity and that this neuroprotection was compromised by pathogenic mutation in the gene. A loss of neuroprotective functions contributes to the pathogenesis of VPS35 mutation in Parkinson's disease. © Ivyspring International Publisher.

authors

publication date

  • January 26, 2013

published in

Digital Object Identifier (DOI)

start page

  • 149

end page

  • 155

volume

  • 9

issue

  • 2