Omega-3 fatty acid monotherapy for pediatric bipolar disorder: A prospective open-label trial Article

Wozniak, J, Biederman, J, Mick, E et al. (2007). Omega-3 fatty acid monotherapy for pediatric bipolar disorder: A prospective open-label trial . European Neuropsychopharmacology, 17(6-7), 440-447. 10.1016/j.euroneuro.2006.11.006

cited authors

  • Wozniak, J; Biederman, J; Mick, E; Waxmonsky, J; Hantsoo, L; Best, C; Cluette-Brown, JE; Laposata, M

abstract

  • Background: To test the effectiveness and safety of omega-3 fatty acids (Omegabrite® brand) in the treatment of pediatric bipolar disorder (BPD). Method: Subjects (N = 20) were outpatients of both sexes, 6 to 17 years of age, with a DSM-IV diagnosis of BPD and Young Mania Rating Scale (YMRS) score of > 15 treated over an 8-week period in open-label trial with omega-3 fatty acids 1290 mg-4300 mg combined EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid). Results: Subjects experienced a statistically significant but modest 8.9 ± 2.9 point reduction in the YMRS scores (baseline YMRS = 28.9 ± 10.1; endpoint YMRS = 19.1 ± 2.6, p < 0.001). Adverse events were few and mild. Red blood cell membrane levels of EPA and DHA increased in treated subjects. Conclusions: As only 35% of these subjects had a response by the usual accepted criteria of > 50% decrease on the YMRS, omega-3 fatty acids treatment was associated with a very modest improvement in manic symptoms in children with BPD. © 2007 Elsevier B.V. and ECNP.

authors

publication date

  • May 1, 2007

published in

Digital Object Identifier (DOI)

start page

  • 440

end page

  • 447

volume

  • 17

issue

  • 6-7