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Novel approaches to using PDE4 inhibitors for antihypertensive therapy
Article
Wang, D, Wang, T. (2005). Novel approaches to using PDE4 inhibitors for antihypertensive therapy .
6(3), 283-288.
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Wang, D, Wang, T. (2005). Novel approaches to using PDE4 inhibitors for antihypertensive therapy .
6(3), 283-288.
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cited authors
Wang, D; Wang, T
authors
Wang, Ting
abstract
Phosphodiesterase (PDE)4 inhibitors are effective vasodilators. In addition to the treatment of asthma and other inflammatory diseases, such as chronic obstructive pulmonary disease, wide-spectrum PDE4 inhibitors may also be developed for use in antihypertensive therapy, especially in patients with impaired renal function and elevated pulmonary arterial pressure. Rational approaches to overcoming the intrinsic emetogenic response associated with PDE4 inhibition are discussed, and a dual-action drug development that incorporates L-type Ca2+ channel antagonism and selective PDE4 inhibition is proposed. The potential for research and development of such a dual-action agent should eventually provide healthcare professionals with a new category of therapeutic options with which to attempt to combat hypertension. © The Thompson Corporation.
publication date
March 1, 2005
Additional Document Info
start page
283
end page
288
volume
6
issue
3