tert-Butyl isocyanide revisited as a convertible reagent in the Groebke-Blackburn reaction Article

Krasavin, M, Tsirulnikov, S, Nikulnikov, M et al. (2008). tert-Butyl isocyanide revisited as a convertible reagent in the Groebke-Blackburn reaction . TETRAHEDRON LETTERS, 49(51), 7318-7321. 10.1016/j.tetlet.2008.10.046

cited authors

  • Krasavin, M; Tsirulnikov, S; Nikulnikov, M; Sandulenko, Y; Bukhryakov, K

authors

abstract

  • tert-Butyl isocyanide can serve as the convertible reagent in Groebke-Blackburn multi-component reactions. The effective removal of the tert-butyl group from the resulting imidazo[1,2-a]azines and -azoles is achieved on a gram scale in two steps without chromatographic purification. © 2008 Elsevier Ltd. All rights reserved.

publication date

  • December 15, 2008

published in

Digital Object Identifier (DOI)

start page

  • 7318

end page

  • 7321

volume

  • 49

issue

  • 51