Intraductal carcinoma (carcinoma in situ) of the pancreas with microinvasion Article

Castellano-Sanchez, AA, Perez, MT, Cabello-Inchausti, B et al. (1999). Intraductal carcinoma (carcinoma in situ) of the pancreas with microinvasion . ANNALS OF DIAGNOSTIC PATHOLOGY, 3(1), 39-47. 10.1016/S1092-9134(99)80008-2

cited authors

  • Castellano-Sanchez, AA; Perez, MT; Cabello-Inchausti, B; Willis, IH; Pelaez, B; Davila, E


  • We report a case of predominantly intraductal carcinoma of the pancreas with microscopic foci of invasive carcinoma in a patient with chronic pancreatitis. In this article, we discuss the pathologic and prognostic features of pancreatic carcinoma in situ. This entity is probably overlooked due to a number of reasons, including the fact that, in most cases, pancreatic ductal carcinomas are extensively infiltrative at the time of surgical removal; the atypical epithelial changes in the intraductal carcinoma had been overlooked in the presence or absence of an invasive component; epithelial changes may be missed due to insufficient sampling; and last, the differentiation with atypical epithelial hyperplasia is a subjective matter. Intraductal carcinoma of the pancreas is a distinct pathological entity with characteristic morphologic changes restricted to the ductal epithelium, bearing important prognostic implications. Copyright © 1999 by W.B. Sounders Company.

publication date

  • January 1, 1999

published in

Digital Object Identifier (DOI)

start page

  • 39

end page

  • 47


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