Amniotic fluid PAH clearance test. A preliminary report Article

Edelberg, SC, Kochwa, S, Rosenfield, RE et al. (1968). Amniotic fluid PAH clearance test. A preliminary report . AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 102(4), 585-590. 10.1016/0002-9378(68)90542-5

cited authors

  • Edelberg, SC; Kochwa, S; Rosenfield, RE; Cherry, SH

authors

abstract

  • Normal pregnant women and an abnormal group with diabetes, hypertension, and pre-eclampsia (conditions commonly associated with placental insufficiency) were studied by injecting para-aminohippurate (PAH) into the amniotic fluid. Maternal urinary output of PAH was determined over a 6 hour period and in some cases the disappearance of PAH from the amniotic fluid was measured directly. Apparent amniotic fluid clearance and per cent recovery of PAH in maternal urine were calculated. Results revealed that both amniotic fluid PAH clearance and per cent recovery of PAH in urine were decreased in pre-eclampsia, hypertension, and progestational diabetes. Decreased clearances and per cent urinary recoveries of PAH in these conditions may be related to decreased uterine and/or placental blood flow or increased myometrial tone and may correlate with fetal disease in utero. © 1968.

publication date

  • October 15, 1968

published in

Digital Object Identifier (DOI)

start page

  • 585

end page

  • 590

volume

  • 102

issue

  • 4