CCR2 mediates increases in glial activation caused by exposure to HIV-1 Tat and opiates Article

El-Hage, N, Wu, G, Ambati, J et al. (2006). CCR2 mediates increases in glial activation caused by exposure to HIV-1 Tat and opiates . JOURNAL OF NEUROIMMUNOLOGY, 178(1-2), 9-16. 10.1016/j.jneuroim.2006.05.027

cited authors

  • El-Hage, N; Wu, G; Ambati, J; Bruce-Keller, AJ; Knapp, PE; Hauser, KF

authors

abstract

  • To assess the role of CCL2/MCP-1 in opiate drug abuse and HIV-1 comorbidity, the effects of systemic morphine and intrastriatal HIV-1 Tat on macrophage/microglial and astroglial activation were assessed in wild type and CCR2 null mice. Tat and/or morphine additively increased the proportion of CCL2 immunoreactive astroglia. The effects of morphine were prevented by naltrexone. Glial activation was significantly reduced in CCR2(-/-) versus wild-type mice following Tat or morphine plus Tat exposure. Thus, CCR2 contributes to local glial activation caused by Tat alone or in the presence of opiates, implicating CCR2 signaling in HIV-1 neuropathogenesis in drug abusers and non-abusers. © 2006 Elsevier B.V. All rights reserved.

publication date

  • September 1, 2006

published in

Digital Object Identifier (DOI)

start page

  • 9

end page

  • 16

volume

  • 178

issue

  • 1-2