Distinct regulatory pathways control expression of Borrelia burgdorferi infection-associated OspC and Erp surface proteins Article

Babb, K, El-Hage, N, Miller, JC et al. (2001). Distinct regulatory pathways control expression of Borrelia burgdorferi infection-associated OspC and Erp surface proteins . INFECTION AND IMMUNITY, 69(6), 4146-4153. 10.1128/IAI.69.6.4146-4153.2001

cited authors

  • Babb, K; El-Hage, N; Miller, JC; Carroll, JA; Stevenson, B

authors

abstract

  • Deciphering the mechanisms by which Borrelia burgdorferi controls the synthesis of proteins associated with mammalian infection will be an important step toward understanding the pathogenic properties of Lyme disease-causing bacteria. We present results of studies indicating that B. burgdorferi senses a wide variety of environmental stimuli, including soluble chemicals, which enables it to independently control synthesis of the Erp and OspC proteins. Regulation of OspC and Erp expression appears to occur at the level of transcription. In this regard, we observed that one or more DNA-binding proteins interact specifically with erp promoter DNA but not with the ospC promoter.

publication date

  • June 11, 2001

published in

Digital Object Identifier (DOI)

start page

  • 4146

end page

  • 4153

volume

  • 69

issue

  • 6