Association of drug abuse with inhibition of HIV-1 immune responses: Studies with long-term of HIV-1 non-progressors Conference

Nair, MPN, Mahajan, S, Hewitt, R et al. (2004). Association of drug abuse with inhibition of HIV-1 immune responses: Studies with long-term of HIV-1 non-progressors . JOURNAL OF NEUROIMMUNOLOGY, 147(1-2), 21-25. 10.1016/j.jneuroim.2003.10.038

cited authors

  • Nair, MPN; Mahajan, S; Hewitt, R; Whitney, ZRB; Schwartz, SA

authors

abstract

  • Recreational drug use has been proposed to affect the course of human immunodeficiency virus (HIV) infections. To investigate the effects of substance abuse on HIV infections, we compared virus-specific cytotoxic T lymphocyte (CTL) responses and the expression of IL-16, TGF-β1, and CXCR4 in three different cohorts of HIV-infected patients: (1) long-term nonprogressors (LT-NPs) of HIV infection who do not use recreational drugs; (2) nondrugs using normal progressors (NPs), and (3) drugs using NPs. Our results show that LT-NPs manifest increased CTL activity and IL-16 expression and decreased expression of TGF-β1 and CXCR4 compared to NPs, regardless of recreational drug usage. Furthermore, drugs using NPs showed significantly lower levels of CTL and IL-16 expression and increased TGF-β1 and CXCR4 expression compared to nondrugs using NPs. Our results suggest that recreational drug use may reduce CTL and IL-16 expression and increase the expression of TGF-β1 and CXCR4, all of which may facilitate progression of HIV infections. © 2003 Published by Elsevier B.V.

publication date

  • January 1, 2004

published in

Digital Object Identifier (DOI)

start page

  • 21

end page

  • 25

volume

  • 147

issue

  • 1-2