Spontaneous and antibody-dependent cell-mediated cytotoxicity by human T cell subpopulations
Article
Gupta, S, Fernandes, G, Nair, M et al. (1978). Spontaneous and antibody-dependent cell-mediated cytotoxicity by human T cell subpopulations
. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 75(10), 5137-5141. 10.1073/pnas.75.10.5137
Gupta, S, Fernandes, G, Nair, M et al. (1978). Spontaneous and antibody-dependent cell-mediated cytotoxicity by human T cell subpopulations
. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 75(10), 5137-5141. 10.1073/pnas.75.10.5137
Human peripheral blood non-T cells, T cells, and their subpopulations (Tμ, Tγ, T∅, Tγ-depleted cells, and Tμ-depleted cells) were assayed for their capacity to mediate spontaneous lymphocyte-mediated cytotoxicity (SLMC) or natural killer activity against K562 tumor cell line and antibody-dependent cellular cytotoxicity (ADCC) against chicken erythrocytes coated with antibody. Non-T cells, unseparated T cells, Tγ cells, and Tμ-depleted (Tγ-enriched) cells were found to have both SLMC (N(K) activity) and ADCC. Tμ, T∅ and Tγ-depleted cells had minimal or no SLMC and ADCC activity. This study demonstrated that SLMC and ADCC activity in T cells is mediated by Tγ cell subpopulations. These two cytotoxic reactions were either mediated by two distinct subsets of Tγ-cells or by a single effector cell using two different mechanisms.
