Dragocins A?D, Structurally Intriguing Cytotoxic Metabolites from a Panamanian Marine Cyanobacterium Article

Choi, H, Engene, N, Byrum, T et al. (2019). Dragocins A?D, Structurally Intriguing Cytotoxic Metabolites from a Panamanian Marine Cyanobacterium . ORGANIC LETTERS, 21(1), 266-270. 10.1021/acs.orglett.8b03712

cited authors

  • Choi, H; Engene, N; Byrum, T; Hwang, S; Oh, DC; Gerwick, WH

authors

abstract

  • Dragocins A-D (1-4) were isolated from a dark-red wooly textured marine cyanobacterium collected in Boca del Drago, Panama. Dragocins A-C (1-3) possessed 2,3-dihydroxypyrrolidine, 1-hydroxy-5-O-Me-benzoyl, and 4′-substituted-β-ribofuranose moieties that connected to form a nine-membered macrocyclic ring. Dragocins A-C are members of a unique hybrid structural class with substitution at the C-4′ position of a ribofuranose unit. Of the four new compounds, dragocin A was the most potent cytotoxin to human H-460 lung cancer cells.

publication date

  • January 4, 2019

published in

Digital Object Identifier (DOI)

start page

  • 266

end page

  • 270

volume

  • 21

issue

  • 1