High-molecular-weight hydroxypropylmethylcellulose taken with or between meals is hypocholesterolemic in adult men
Article
Maki, KC, Davidson, MH, Torri, S et al. (2000). High-molecular-weight hydroxypropylmethylcellulose taken with or between meals is hypocholesterolemic in adult men
. JOURNAL OF NUTRITION, 130(7), 1705-1710. 10.1093/jn/130.7.1705
Maki, KC, Davidson, MH, Torri, S et al. (2000). High-molecular-weight hydroxypropylmethylcellulose taken with or between meals is hypocholesterolemic in adult men
. JOURNAL OF NUTRITION, 130(7), 1705-1710. 10.1093/jn/130.7.1705
Hydroxypropylmethylcellulose (HPMC) is a food gum that shares certain characteristics, such as high viscosity, with soluble fibers. In this trial, the safety and cholesterol-lowering efficacy of HPMC consumed with and between meals was evaluated in free-living male volunteers with mild-to- moderate hypercholesterolemia. After a 14-d baseline period, men (n = 51) with LDL cholesterol between 3.36 and 4.91 mmol/L and triglycerides <3.95 mmol/L were randomly assigned to consume 5.0 g/d HPMC in 240 mL of orange drink, taken either with or between meals, for a 2-wk treatment period. In the Between Meals group, total cholesterol was reduced by 8.0% vs. baseline in wk 1 of treatment (P < 0.05) and 5.1% in wk 2 (P < 0.01). LDL cholesterol concentrations fell by 12.0 and 7.7% (P < 0.01). In the with Meals group, reductions were 9.5 and 8.3% for total cholesterol, and 12.5 and 12.8% for LDE cholesterol (wk 1 and 2 respectively, P < 0.01). In both groups, HDL cholesterol decreased by ~5% during wk 1 of treatment (P < 0.01), but the wk 2 concentrations were not significantly different from baseline. There were no significant differences between groups in lipid responses, although there was a trend for a smaller LDL cholesterol-lowering effect during wk 2 of treatment in the Between Meals group (P < 0.06). Gastrointestinal-related adverse experiences (mostly mild) were twice as common among participants who ingested HPMC with meals (P < 0.05). These results suggest that HPMC has a lipid-lowering effect, which may be more consistent when taken with meals.
