Diagnosis by polymerase chain reaction of ocular posttransplant lymphoproliferative disorder after pediatric renal transplantation Article

Al-Attar, L, Berrocal, A, Warman, R et al. (2004). Diagnosis by polymerase chain reaction of ocular posttransplant lymphoproliferative disorder after pediatric renal transplantation . AMERICAN JOURNAL OF OPHTHALMOLOGY, 137(3), 569-571. 10.1016/j.ajo.2003.08.013

cited authors

  • Al-Attar, L; Berrocal, A; Warman, R; Dubovy, S; Paredes, A; Chan, CC; Davis, J

authors

abstract

  • Purpose To report diagnosis by polymerase chain reaction of intraocular posttransplant lymphoproliferative disorder in a pediatric renal transplant patient. Design Observational case report. Methods Retrospective review. Results An 11-year-old girl developed infectious mononucleosis 15 months after renal transplantation for focal segmental sclerosis. Papillitis and hypopyon uveitis developed 8 months later, followed by iris nodules. Diagnosis of intraocular posttransplant lymphoproliferative disorder was made by polymerase chain reaction of aqueous humor for Epstein-Barr virus and confirmed by histopathology of an iris biopsy specimen. Infiltrating iris lymphocytes in the biopsy specimen were positive for Epstein-Barr DNA. Polymerase chain reaction also revealed gene rearrangement of the variable region of the heavy immunoglobulin chain, consistent with a monoclonal B-lymphocyte population. Iris nodules resolved with reduction in immunosuppressive medication. Conclusion Polymerase chain reaction for Epstein-Barr virus may be helpful in diagnosis of intraocular posttransplant lymphoproliferative disorder. © 2004 by Elsevier Inc. All rights reserved.

publication date

  • January 1, 2004

published in

Digital Object Identifier (DOI)

start page

  • 569

end page

  • 571

volume

  • 137

issue

  • 3