γ-Diketone neuropathy: Axon atrophy and the role of cytoskeletal protein adduction Article

LoPachin, RM, DeCaprio, AP. (2004). γ-Diketone neuropathy: Axon atrophy and the role of cytoskeletal protein adduction . TOXICOLOGY AND APPLIED PHARMACOLOGY, 199(1), 20-34. 10.1016/j.taap.2004.03.008

cited authors

  • LoPachin, RM; DeCaprio, AP

authors

abstract

  • Multifocal giant neurofilamentous axonal swellings and secondary distal degeneration have been historically considered the hallmark features of γ-diketone neuropathy. Accordingly, research conducted over the past 25 years has been directed toward discerning mechanisms of axonal swelling. However, this neuropathological convention has been challenged by recent observations that swollen axons were an exclusive product of long-term 2,5-hexanedione (HD) intoxication at lower daily dose-rates (e.g., 175 mg/kg/day); that is, higher HD dose-rates (e.g., 400 mg/kg/day) produced neurological deficits in the absence of axonal swellings. The observation that neurological toxicity can be expressed without axonal swelling suggests that this lesion is not an important pathophysiological event. Instead, several research groups have now shown that axon atrophy is prevalent in nervous tissues of laboratory animals intoxicated over a wide range of HD dose-rates. The well-documented nerve conduction defects associated with axon atrophy, in conjunction with the temporal correspondence between this lesion and the onset of neurological deficits, strongly suggest that atrophy has pathophysiological significance. In this commentary, we present evidence that supports a pathognomonic role for axon atrophy in γ-diketone neuropathy and suggests that the functional consequences of this lesion mediate the corresponding neurological toxicity. Previous research has demonstrated that HD interacts with proteins via formation of pyrrole adducts. We therefore discuss the possibility that this chemical process is essential to the mechanism of atrophy. Evidence presented in this review suggests that "distal axonopathy" is an inaccurate classification and future nosological schemes should be based on the apparent primacy of axon atrophy. © 2004 Elsevier Inc. All rights reserved.

publication date

  • August 15, 2004

published in

Digital Object Identifier (DOI)

start page

  • 20

end page

  • 34

volume

  • 199

issue

  • 1