Cellular immune response to pulmonary infections in HIV-infected individuals hospitalized with diverse grades of immunosuppression Article

Miguez-Burbano, MJ, Ashkin, D, Rodriguez, A et al. (2006). Cellular immune response to pulmonary infections in HIV-infected individuals hospitalized with diverse grades of immunosuppression . EPIDEMIOLOGY AND INFECTION, 134(2), 271-278. 10.1017/S0950268805005030

cited authors

  • Miguez-Burbano, MJ; Ashkin, D; Rodriguez, A; Duncan, R; Flores, M; Acosta, B; Quintero, N; Pitchenik, A

authors

abstract

  • The lymphocyte profile of 521 HIV-infected subjects hospitalized at Jackson Memorial (2001-2002) was compared across main respiratory diseases. Study data included medical history and all laboratory evaluations performed during hospitalization. Community-acquired pneumonias (CAP, 52%), Pneumocystis jiroveci pneumonia (PCP, 24%), tuberculosis (TB, 9%) and non-tuberculous mycobacterial diseases (NTM, 12%) were the most frequent causes of admission. Patients hospitalized with PCP and NTM exhibited the lowest CD4 counts (P=0.003). PCP patients had the highest B-cell percentages (P=0.04). CAP patients had the highest CD8 and CD4 percentages and the lowest percentage of Natural Killer (NK) cells and viral burdens. TB patients exhibited the lowest NK-cell (11.4±6.3) and B-cell percentages (13.6±12) and the highest CD8 (59±14) percentage. NTM patients, in contrast, had the highest NK-cell percentages of the groups (19.1±11.6, P=0.01). Additionally, immune responses associated with respiratory pathogens differed in HIV-infected patients with CD4+ cells above and below 200 counts. © 2005 Cambridge University Press.

publication date

  • April 1, 2006

published in

Digital Object Identifier (DOI)

start page

  • 271

end page

  • 278

volume

  • 134

issue

  • 2