Distal Sensory Polyneuropathy in the Context of HIV/AIDS Article

Nicholas, PK, Mauceri, L, Slate Ciampa, A et al. (2007). Distal Sensory Polyneuropathy in the Context of HIV/AIDS . JANAC-JOURNAL OF THE ASSOCIATION OF NURSES IN AIDS CARE, 18(4), 32-40. 10.1016/j.jana.2007.05.003

cited authors

  • Nicholas, PK; Mauceri, L; Slate Ciampa, A; Corless, IB; Raymond, N; Barry, DJ; Viamonte Ros, A


  • Peripheral neuropathy, or distal sensory polyneuropathy (DSPN), is the most common neurological problem in HIV disease. DSPN also represents a complex symptom that occurs because of peripheral nerve damage related to advanced HIV disease and in association with the use of antiretroviral therapy-particularly in individuals treated with dideoxynucleosides. Although DSPN is a frequent symptom, the specific pathophysiology is not well understood. The HIV-related neuropathies are commonly categorized as distal sensory polyneuropathies, although antiretroviral toxic neuropathies are described in the literature. Recently, mitochondrial toxicity has been identified as a possible etiology of DSPN. As individuals with HIV/AIDS survive longer, often living for decades with the disease, chronic symptoms like DSPN must be addressed. Pharmacologic approaches, complementary therapies, and self-care behaviors that may improve quality of life and limit symptoms of DSPN are important interventions for clinicians and those living with HIV/AIDS to consider in the management of peripheral neuropathy. © 2007 Association of Nurses in AIDS Care.

publication date

  • July 1, 2007

Digital Object Identifier (DOI)

start page

  • 32

end page

  • 40


  • 18


  • 4