Inhibition of human immunodeficiency virus replication by azidothymidine (Azitidín Lachema) in cultured cells
Article
Schmidtmayerová, H, Mayer, V. (1993). Inhibition of human immunodeficiency virus replication by azidothymidine (Azitidín Lachema) in cultured cells
. 94(2), 76-80.
Schmidtmayerová, H, Mayer, V. (1993). Inhibition of human immunodeficiency virus replication by azidothymidine (Azitidín Lachema) in cultured cells
. 94(2), 76-80.
The inhibitory effect of the Czecho-Slovakia azidothymidine (AZT) preparation Azitidin (Lachema) on HIV 1 infection was studied in vitro. Its efficacy was compared with that of the approved AZT preparation Retrovir (Burroughs-Wellcome Co.). HIV 1 infected MT4 cells were cultivated in media containing different concentrations of Azitidin or Retrovir. Complete inhibition of virus production (reverse transcriptase activity) and of the cytopathic effect of HIV 1 was seen at the concentration of 0.1 microM of either preparation. Complete inhibition of viral antigen induction was recorded at the concentration of 1 microM. In the light of the obtained results we can conclude that Azitidin inhibits HIV 1 replication in vitro and its efficacy is fully comparable to that of Retrovir. (Tab. 4, Fig. 2, Ref. 17.)
