Surgery for epilepsy due to cortical malformations: Ten-year follow-up Article

Hamiwka, L, Jayakar, P, Resnick, T et al. (2005). Surgery for epilepsy due to cortical malformations: Ten-year follow-up . EPILEPSIA, 46(4), 556-560. 10.1111/j.0013-9580.2005.52504.x

cited authors

  • Hamiwka, L; Jayakar, P; Resnick, T; Morrison, G; Ragheb, J; Dean, P; Dunoyer, C; Duchowny, M

authors

abstract

  • Children with malformations of cortical development represent a significant proportion of pediatric epilepsy surgery candidates. From a cohort of 40 children operated on between 1980 and 1992 with malformation of cortical development, 38 were alive and had data 10 years after surgery. Age at surgery ranged from 6 months to 18 years (mean, 9.6 years). Thirty-six had partial seizures, and two had infantile spasms; 20 were nonlesional. Pathologic diagnoses were cortical dysplasia (n = 31) and developmental tumor (n = 7). At 10-year follow-up, 15 (40%) were seizure free, 10 (26%) had >90% seizure reduction, and 13 (34%) were improved or unchanged. Children seizure free at two-year follow-up were likely to remain seizure free. Ten-year seizure freedom was 72% in children with developmental tumors and 32% in the cortical dysplasia group. Complete resection was statistically significant for favorable outcome, and no patient with an incomplete resection was seizure free. © 2005 International League Against Epilepsy.

publication date

  • April 1, 2005

published in

Digital Object Identifier (DOI)

start page

  • 556

end page

  • 560

volume

  • 46

issue

  • 4