Pyoderma gangrenosum - Rebel without a cure? Article

Jacob, SE, Weisman, RS, Kerdel, FA. (2008). Pyoderma gangrenosum - Rebel without a cure? . INTERNATIONAL JOURNAL OF DERMATOLOGY, 47(2), 192-194. 10.1111/j.1365-4632.2008.03412.x

cited authors

  • Jacob, SE; Weisman, RS; Kerdel, FA

authors

abstract

  • Background: Pyoderma gangrenosum (PG) is a rare neutrophilic, ulcerating dermatosis that is frequently difficult to diagnose and often a diagnosis of exclusion. It is hypothesized that PG may be caused by an abnormal T-cell and neutrophil response, which correlates with its common link to other disorders, such as inflammatory bowel disease, rheumatoid arthritis, and malignancies. Several treatments have been used successfully for PG, but none has proven to be universally effective. Methods: We present three cases of PG treated with adalimumab after failed courses of steroids (orally and parenterally), thalidomide, cyclosporine, and mycophenolate mofetil. Results: Patients 2 and 3, who had previously responded to infliximab, albeit with recurrence, were successfully treated with adalimumab at a dose of 40 mg once a week. Patient 1 initially responded to adalimumab, but after 7.5 months failed to show wound bed improvement at a dose of 80 mg/week subcutaneously. This patient had not previously been treated with infliximab. Conclusion: We believe adalimumab to be a valuable alternative for the treatment of PG, with comparable efficacy to infliximab. © 2008 The International Society of Dermatology.

publication date

  • February 1, 2008

published in

Digital Object Identifier (DOI)

start page

  • 192

end page

  • 194

volume

  • 47

issue

  • 2