Successful treatment of lichen planus with low-molecular-weight heparin: A case series of seven patients
Article
Pacheco, H, Kerdel, F. (2001). Successful treatment of lichen planus with low-molecular-weight heparin: A case series of seven patients
. JOURNAL OF DERMATOLOGICAL TREATMENT, 12(2), 123-126. 10.1080/095466301317085444
Pacheco, H, Kerdel, F. (2001). Successful treatment of lichen planus with low-molecular-weight heparin: A case series of seven patients
. JOURNAL OF DERMATOLOGICAL TREATMENT, 12(2), 123-126. 10.1080/095466301317085444
BACKGROUND: Lichen planus (LP) is characterized by features of a cell-mediated attack on the epidermis by activated T lymphocytes. CD4+ lymphocytes have been shown to produce endoglycosidase (heparanase), which allows them to penetrate into the subendothelial basal lamina. Low-molecular-weight heparin (enoxaparin) has been shown to inhibit expression of heparanase. METHODS: Seven patients with LP were treated with enoxaparin. RESULTS: Five experienced a marked improvement with no side effects. CONCLUSION: Enoxaparin may be an effective treatment for patients with lichen planus.
