Adult T-cell leukemia/lymphoma associated with noninfectious epithelioid granuloma in the skin: A clinicopathologic study
Article
Setoyama, M, Katahira, Y, Kanzaki, T et al. (1997). Adult T-cell leukemia/lymphoma associated with noninfectious epithelioid granuloma in the skin: A clinicopathologic study
. 19(6), 591-595. 10.1097/00000372-199712000-00007
Setoyama, M, Katahira, Y, Kanzaki, T et al. (1997). Adult T-cell leukemia/lymphoma associated with noninfectious epithelioid granuloma in the skin: A clinicopathologic study
. 19(6), 591-595. 10.1097/00000372-199712000-00007
Hodgkin's disease (HD) and non-Hodgkin's lymphoma (NHL) are infrequently associated with noninfectious granulomas in involved or noninvolved organs. Adult T-cell leukemia/lymphoma (ATLL) is an aggressive lymphoproliferative neoplasm associated with T-lymphotropic virus type 1 (HTLV-1). We describe a case of cutaneous type ATLL, affecting mainly the skin as a maculopapular eruption, in which some skin biopsies contained epithelioid cell granulomas in the lymphoma cutis (ATLL) lesion. These Lennert's-like epithelioid clusters were also present in lymph nodes, which showed some degree of invasion by the ATLL lymphocytes. Although prognosis of ATLL is generally poor, our patient has had a less aggressive course, with a survival time to date of 13 years. Our findings suggest that the presence of epithelioid granulomata in an ATLL patient may be a manifestation of a host response which confers some protection against the disease progression. To our knowledge, this is the first report of a case of ATLL with a noninfectious granuloma similar to a Lennert's lesion.
