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Heat Shock Protein-Based Cancer Vaccines
Article
Lee, KP, Raez, LE, Podack, ER. (2006). Heat Shock Protein-Based Cancer Vaccines .
20(3), 637-659. 10.1016/j.hoc.2006.02.007
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Lee, KP, Raez, LE, Podack, ER. (2006). Heat Shock Protein-Based Cancer Vaccines .
20(3), 637-659. 10.1016/j.hoc.2006.02.007
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cited authors
Lee, KP; Raez, LE; Podack, ER
authors
Raez, Luis
abstract
The ability to duplicate the remarkable success of infectious disease vaccines in cancer, with durably robust and highly specific antitumor immune responses, has been long held as one of the keys in developing true "magic bullet" cancer therapies. This article attempts to explain why cancer vaccines have failed (so far), delineate the increasingly complex barriers that prevent the eliciting of effective antitumor immunity and examines the ability of heat shock protein-based vaccines to overcome these barriers. This article is not a definitive compendium of the huge body of relevant literature but rather focuses on the major concepts underlying active specific immunotherapy in general and heat shock protein vaccines in particular. © 2006 Elsevier Inc. All rights reserved.
publication date
June 1, 2006
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Digital Object Identifier (DOI)
https://doi.org/10.1016/j.hoc.2006.02.007
Additional Document Info
start page
637
end page
659
volume
20
issue
3