DNA methylation: Its role in lung carcinogenesis and therapeutic implications Review

Santos, ES, Raez, LE, DeCesare, T et al. (2005). DNA methylation: Its role in lung carcinogenesis and therapeutic implications . Expert Review of Anticancer Therapy, 5(4), 667-679. 10.1586/14737140.5.4.667

cited authors

  • Santos, ES; Raez, LE; DeCesare, T; Singal, R

abstract

  • A new era in the treatment of malignant diseases has been observed through the use of biologic agents targeting growth factor receptors, signaling pathways, gene mutations and others. The results have been impressive in some diseases and modest in others. The discovery of new targets has expanded our knowledge of different mechanisms in tumorigenesis. One of these mechanisms has been DNA methylation, which is an important gene transcription regulator. Although the role of methylation in lung carcinogenesis is not well understood, there is an enormous quantity of evolving data suggesting its critical role in lung cancer. In this review, the authors will discuss methylation in lung carcinogenesis and its possible clinical implications. © 2005 Future Drugs Ltd.

authors

publication date

  • August 1, 2005

published in

Digital Object Identifier (DOI)

start page

  • 667

end page

  • 679

volume

  • 5

issue

  • 4