Allogeneic tumor-cell-based vaccines secreting endoplasmic reticulum chaperone gp96 Review

Podack, ER, Raez, LE. (2007). Allogeneic tumor-cell-based vaccines secreting endoplasmic reticulum chaperone gp96 . Expert Opinion on Biological Therapy, 7(11), 1679-1688. 10.1517/14712598.7.11.1679

cited authors

  • Podack, ER; Raez, LE

abstract

  • Heat-shock proteins are chaperones for proteins including tumor antigens. Heat-shock protein gp96, also known as glucose-regulated protein grp94, is the primary chaperone of the endoplasmic reticulum and a natural adjuvant for priming the innate and adaptive immune system. By transferring tumor cells with a genetically modified secretory form of gp96, the tumor cells are transformed into vaccine cells. Gp96 vaccines in murine studies trigger robust innate and antigen-specific cellular immune responses and cause tumor rejection followed by long-lasting tumor immunity. The authors briefly review here the generation of cytotoxic T lymphocyte responses by gp96 and the most up to date clinical data in the use of gp96-based cancer vaccines. © 2007 Informa UK Ltd.

authors

publication date

  • November 1, 2007

published in

Digital Object Identifier (DOI)

start page

  • 1679

end page

  • 1688

volume

  • 7

issue

  • 11