Novel molecular targeted therapies for refractory thyroid cancer Article

Perez, CA, Santos, ES, Arango, BA et al. (2012). Novel molecular targeted therapies for refractory thyroid cancer . HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 34(5), 736-745. 10.1002/hed.21755

cited authors

  • Perez, CA; Santos, ES; Arango, BA; Raez, LE; Cohen, EEW



  • The incidence of thyroid cancer continues to increase and this neoplasia remains the most common endocrine malignancy. No effective systemic treatment currently exists for iodine-refractory differentiated or medullary thyroid carcinoma, but recent advances in the pathogenesis of these diseases have revealed key targets that are now being evaluated in the clinical setting. RET (rearranged during transfection)/PTC (papillary thyroid carcinoma) gene rearrangements, B-Raf gene mutations, and vascular endothelial growth factor receptor 2 (VEGFR-2) angiogenesis pathways are some of the known genetic alterations playing a crucial role in the development of thyroid cancer. Several novel agents have demonstrated promising responses. Of the treatments studied, multi-kinase inhibitors such as axitinib, sorafenib, motesanib, and XL-184 have shown to be the most effective by inducing clinical responses and stabilizing the disease process. Randomized clinical trials are currently evaluating these agents, results that may soon change the management of thyroid cancer. © 2011 Wiley Periodicals, Inc.

publication date

  • May 1, 2012

Digital Object Identifier (DOI)

start page

  • 736

end page

  • 745


  • 34


  • 5