Targeting the Met pathway in lung cancer Review

Belalcazar, A, Azaña, D, Perez, CA et al. (2012). Targeting the Met pathway in lung cancer . Expert Review of Anticancer Therapy, 12(4), 519-528. 10.1586/era.12.16

cited authors

  • Belalcazar, A; Azaña, D; Perez, CA; Raez, LE; Santos, ES

abstract

  • Dysregulation of Met signaling has been implicated in the initiation, progression and metastasis of human cancers, and therefore represents an attractive target for anticancer drug development. Met is overexpressed in non-small-cell lung cancer and its lack of staining in normal lung tissue makes it an attractive target. To date, erlotinib and gefitinib have established themselves as first-line therapy for non-small-cell lung cancer patients whose tumors harbor an EGF receptor gene mutation, and hence, it is crucial that we identify mechanisms of resistance that could be targeted by novel agents, while keeping an acceptable toxicity profile at the same time; something very important when we develop these new drugs. Inhibitors of the Met pathway represent a therapeutic alternative in this setting. In this review, we discuss the early clinical studies reported using two Met inhibitors, a monoclonal antibody (MetMAb) and a small molecule tyrosine kinase inhibitor (MGCD265). © 2012 Expert Reviews Ltd.

authors

publication date

  • April 1, 2012

published in

Digital Object Identifier (DOI)

start page

  • 519

end page

  • 528

volume

  • 12

issue

  • 4