Preimplantation genetic diagnosis: Its time is now: Indications for PGD have extended far beyond single-gene disorders
Editorial Material
Simpson, JL. (2016). Preimplantation genetic diagnosis: Its time is now: Indications for PGD have extended far beyond single-gene disorders
. 61(7), 4-8.
Simpson, JL. (2016). Preimplantation genetic diagnosis: Its time is now: Indications for PGD have extended far beyond single-gene disorders
. 61(7), 4-8.
In 2016 PGD has a well-defined role. Indications have extended far beyond the single-gene disorders that initiated the field 25 years ago to encompass HLA-typing for umbilical and cordblood stem cell transplantation. Twenty-four-chromosome PGD aneuploidy testing identifies euploid embryos to transfer, thus improving the pregnancy rates in ART while reducing the occurrence of multiple gestations. Miscarriage rates in ART are greatly reduced using PGD, and transfer of euploid embryos allows pregnancy rates to remain relatively undiminished until age 42. All this enables single-embryo transfer to be practical.
