Conjugated quantum dots inhibit the amyloid β(1-42) fibrillation process

Conjugated quantum dots inhibit the amyloid β(1-42) fibrillation process Article

Leblanc, RM, Thakur, G, Micic, M et al. (2011). Conjugated quantum dots inhibit the amyloid β(1-42) fibrillation process . 10.4061/2011/502386

Leblanc, RM; Thakur, G; Micic, M; Yang, Y; Li, W; Movia, D; Giordani, S; Zhang, H

Nanoparticles have enormous potential in diagnostic and therapeutic studies. We have demonstrated that the amyloid beta mixed with and conjugated to dihydrolipoic acid- (DHLA) capped CdSe/ZnS quantum dots (QDs) of size approximately 2.5nm can be used to reduce the fibrillation process. Transmission electron microscopy (TEM) and atomic force microscopy (AFM) were used as tools for analysis of fibrillation. There is a significant change in morphology of fibrils when amyloid β(1-42) (Aβ (1-42)) is mixed or conjugated to the QDs. The length and the width of the fibrils vary under modified conditions. Thioflavin T (ThT) fluorescence supports the decrease in fibril formation in presence of DHLA-capped QDs. © 2011 Garima Thakur et al.