Chemical derivatization for selective detection and identification of alcohols by electrospray mass spectrometry
Conference
Quirke, JME, Van Berkel, GJ. (2001). Chemical derivatization for selective detection and identification of alcohols by electrospray mass spectrometry
. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 41(1), 633-637.
Quirke, JME, Van Berkel, GJ. (2001). Chemical derivatization for selective detection and identification of alcohols by electrospray mass spectrometry
. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 41(1), 633-637.
The speed and sensitivity of electrospray MS (ESMS) and chemical derivatization for selective detection of non-ionic analytes were presented. The methodologies provided rapid, selective detection of analytes, and in some cases, the ability to distinguish among positional isomers of analytes bearing the same functional group. Product ion spectra of ferrocene carbamate ester derivatives of isomeric saturated C6 alcohols (1-hexanol (straight chain primary alcohol), 2-ethyl-1-butanol (β-branched primary), 2-hexanol (secondary), 2-methyl-2-pentanol (tertiary alcohol)) were presented. The ESMS analysis of the ferrocene carbamate derivatives of alcohols was a potentially very useful method for detection of alcohols. Straight chain primary alcohol derivatives yielded a mono-substituted alkenes. β-Branched primary alcohol and many secondary alcohol derivatives yielded a disubstituted alkene.