Inhibition of bacterial bioluminescence by pargyline Article

Makemson, J, Hastings, JW. (1979). Inhibition of bacterial bioluminescence by pargyline . ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 196(2), 396-402. 10.1016/0003-9861(79)90290-X

cited authors

  • Makemson, J; Hastings, JW

authors

abstract

  • Pargyline (N-benzyl-N-methyl-2-propynylamine), an inactivator of mitochondrial monoamine oxidase, inhibits growth and in vivo and in vitro bioluminescence in Beneckea harveyi. The inhibition is competitive with the two substrates, FMNH2 and aldehyde, and the inhibitor binds with a reaction intermediate of the the enzyme luciferase to form a stable, but reversible, adduct. Inhibition of in vivo bioluminescence is an apparently complex phenomenon, and may involve a block in the synthesis of aldehyde. © 1979.

publication date

  • January 1, 1979

published in

Digital Object Identifier (DOI)

start page

  • 396

end page

  • 402

volume

  • 196

issue

  • 2