Electrochemically imprinted molecular recognition sites on multiwalled carbon-nanotubes/pencil graphite electrode surface for enantioselective detection of d- and l-aspartic acid Article

Prasad, BB, Pandey, I. (2013). Electrochemically imprinted molecular recognition sites on multiwalled carbon-nanotubes/pencil graphite electrode surface for enantioselective detection of d- and l-aspartic acid . Electrochimica Acta, 88 24-34. 10.1016/j.electacta.2012.10.095

cited authors

  • Prasad, BB; Pandey, I

abstract

  • Molecularly imprinted polymeric nano-materials (thickness 2.03 nm) for aspartic acid enantiomers were electrochemically synthesized onto multi-walled carbon nanotubes immobilized pencil graphite electrode surface. The molecular recognition in this work was based on doping/de-doping characteristics of the conducting polymer, poly (indole-3-acetic acid), wherein the template (aspartic acid) acted as a dopant which could easily be ejected from the polymer backbone after over-oxidation. This resulted in molecular cavities complementary to the template in the imprinted polymer texture. The transduction was made via differential pulse anodic stripping voltammetric detection of d- and l-aspartic acid using respective sensors. The detection limits (S/N = 3) for d- and l-aspartic acid were found to be 0.025 and 0.016 μM, respectively in aqueous solutions. Enantioselective analysis of l-aspartic acid was validated in real samples that suggested practicability of the proposed sensor for the evaluation of this bioactive molecule as a disease biomarker in clinical settings, without any cross-reactivity and false-positives. © 2012 Elsevier Ltd. All rights reserved.

authors

publication date

  • January 15, 2013

published in

Digital Object Identifier (DOI)

start page

  • 24

end page

  • 34

volume

  • 88