Molecularly imprinted polymer-based piezoelectric sensor for enantio-selective analysis of malic acid isomers Article

Prasad, BB, Pandey, I. (2013). Molecularly imprinted polymer-based piezoelectric sensor for enantio-selective analysis of malic acid isomers . SENSORS AND ACTUATORS B-CHEMICAL, 181 596-604. 10.1016/j.snb.2013.02.060

cited authors

  • Prasad, BB; Pandey, I

authors

abstract

  • A quartz crystal microbalance sensor, having enantio-selective ability to analyze malic acid enantiomers with high sensitivity, was fabricated using a biomimetic ultra-thin film of molecularly imprinted polymer. Such material could be termed as 'glyco-molecularly imprinted polymer' since it was synthesized using sugar moiety, adopting non-covalent self-assembly process and subsequent photo-polymerization. The piezoelectric sensor modification via "surface-grafting from" was found to be superior to response better than the physical entrapment of imprinted particles. The glyco-imprinted polymer sensor demonstrated exclusive specificity for l-malic acid, concomitantly present with d-malic acid and respective analogs. The rational design of malic acid/glyco-monomer complex, with composition 1:2, was predicted on the basis of theoretical modeling. The detection limit of l-malic acid was realized as 0.18-0.21 ng mL-1 (S/N = 3, confidence level 95%) for l-malic acid and the linearity was observed within its concentration range 20-210 ng mL -1, at pH 7.0, in aqueous and real samples. The proposed sensor demonstrated a fast, reliable, enantio-selective and quantitative response to malic acid isomers, in real samples. © 2013 Elsevier B.V.

publication date

  • March 25, 2013

published in

Digital Object Identifier (DOI)

start page

  • 596

end page

  • 604

volume

  • 181