FIU Discovery

Paricalcitol Downregulates Myocardial ReninAngiotensin and Fibroblast Growth Factor Expression and Attenuates Cardiac Hypertrophy in Uremic Rats.  AMERICAN JOURNAL OF HYPERTENSION.  27:720-726.

Suppression of renin-angiotensin gene expression in the kidney by paricalcitol.  KIDNEY INTERNATIONAL.  74:1394-1402.

Apoptotic stress pathway activation mediated by iron on endothelial cells in vitro.  NEPHROLOGY DIALYSIS TRANSPLANTATION.  21:3055-3061.

Increased osteoblastic activity and expression of receptor activator of NF-κB ligand in nonuremic nephrotic syndrome.  JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY.  16:2198-2204.

Estrogen receptor (ER) gene polymorphism may predict the bone mineral density response to raloxifene in postmenopausal women on chronic hemodialysis

Outcomes associated with hypogonadism in women with chronic kidney disease

Osteoporosis in chronic kidney disease.  AMERICAN JOURNAL OF KIDNEY DISEASES.  43:566-571.

Abnormalities of bone mineral density and bone metabolism in Venezuelan patients with rheumatoid arthritis

Bone remodeling after renal transplantation.  KIDNEY INTERNATIONAL.  63:S125-S128.

Effects of raloxifene on bone metabolism and serum lipids in postmenopausal women on chronic hemodialysis.  KIDNEY INTERNATIONAL.  63:2269-2274.

Selective estrogen receptor modulators in chronic renal failure.  KIDNEY INTERNATIONAL.  63:S62-S65.

The pathogenesis of osteodystrophy after renal transplantation as detected by early alterations in bone remodeling.  KIDNEY INTERNATIONAL.  63:1915-1923.

The effect of short- and long-term growth hormone treatment on bone mineral density and bone metabolism of prepubertal children with idiopathic short stature: a 3-year study.  CLINICAL ENDOCRINOLOGY.  57:725-730.

Reduced bone mass in children with idiopathic hypercalciuria and in their asymptomatic mothers.  NEPHROLOGY DIALYSIS TRANSPLANTATION.  17:1396-1401.

Decreased bone mineral density and bone formation markers - Shortly after diagnosis of clinical type 1 diabetes mellitus.  JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM.  14:525-528.

Access to medical information in Latin America.  LANCET.  356:S15-S15.

Bone disease in patients with long-term renal transplantation and normal renal function.  AMERICAN JOURNAL OF KIDNEY DISEASES.  36:160-166.

Role of persistent amenorrhea in bone mineral metabolism of young hemodialyzed women.  KIDNEY INTERNATIONAL.  58:331-335.

Clinical algorithms on renal osteodystrophy.  NEPHROLOGY DIALYSIS TRANSPLANTATION.  15:39-57.

Role of hormone replacement in the management of osteoporosis in haemodialysed women: perspectives for the future.  NEPHROLOGY DIALYSIS TRANSPLANTATION.  15:36-37.

Bone disease after renal transplantation.  TRANSPLANTATION PROCEEDINGS.  31:3033-3034.

Decreased bone mass despite long-term estrogen replacement therapy in young women with Turner's syndrome and previously normal bone density.  FERTILITY AND STERILITY.  72:896-899.

Latin American nephrology:: Scientific production and impact of the publications.  KIDNEY INTERNATIONAL.  56:1584-1590.

Decreased trabecular bone mineral density in children with idiopathic short stature: Normalization of bone density and increased bone turnover after 1 year of growth hormone treatment.  JOURNAL OF PEDIATRICS.  135:177-181.

Effect of recombinant human erythropoietin on endothelial cell apoptosis.  KIDNEY INTERNATIONAL.  55:546-553.

Bone loss in hypercalciuria: Cause or consequence?.  AMERICAN JOURNAL OF KIDNEY DISEASES.  33:XLVI-XLVIII.

Magnesium and phosphorus.  LANCET.  352:391-396.

Bone Remodeling Factors in Children with Idiopathic Hypercalciuria (IH) and Osteopenia † 1801.  PEDIATRIC RESEARCH.  43:307-307.

Decreased Bone Mass Despite Long Term Estrogen Replacement in Young Women with Turner's Syndrome (TS) and Previously Normal Bone Mineral Densities (BMD)† 449.  PEDIATRIC RESEARCH.  43:79-79.

Decreased Bone Mineral Densities (BMD) and Bone Formation Markers During the First Year After Diagnosis of Insulin Dependent Diabetes Mellitus (IDDM) in Children. 431.  PEDIATRIC RESEARCH.  43:76-76.

Osteopenia in Asymptomatic Premenopausal Mothers of Children with Idiopathic Hypercalciuria (IH) † 422.  PEDIATRIC RESEARCH.  43:75-75.

Bone disease in hypercalciuria: a new form of osteodystrophy?.  NEPHROLOGY DIALYSIS TRANSPLANTATION.  13:88-90.

What are the bone lesions in patients with more than four years of a functioning renal transplant?.  NEPHROLOGY DIALYSIS TRANSPLANTATION.  13:103-104.

Role of the bone in the physiopathology of idiopathic hypercalciuria. Effect of aminobisphosphonate alendronate.  MEDICINA-BUENOS AIRES.  57:45-48.

Use of intrarenal needle manometry in acute renal dysfunction following renal transplantation

Changes in bone mineral density, growth velocity and renal function of prepuberal uremic children during growth hormone treatment

Changes in bone mineral density (BMD) and total bone mineral content (BMC) in prepubertal children with marked short stature secondary to chronic renal failure (CRF): Effects of biosynthetic growth hormone (rhGH) therapy.  OSTEOPOROSIS INTERNATIONAL.  6:286-286.

Decreased trabecular bone mineral density (BMD) in children and adolescents with insulin dependent diabetes mellitus (IDDM).  OSTEOPOROSIS INTERNATIONAL.  6:286-286.

Interleukin-1α (IL-1α), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) mRNA expression in unstimulated peripheral blood mononuclear cells (PBMCs) in kidney stone patients with idiopathic hypercalciuria.  OSTEOPOROSIS INTERNATIONAL.  6:101-101.

Possible role of cytokines on the bone mineral loss in idiopathic hypercalciuria.  KIDNEY INTERNATIONAL.  49:244-250.

Role of the bone in the pathogenesis of idiopathic hypercalciuria (IH): Effect of aminobisphosphonate alendronate (ALN).  OSTEOPOROSIS INTERNATIONAL.  6:286-286.

[Impact of the Hospital Coordinator Program on obtaining kidneys for renal transplantation]..  INVESTIGACION CLINICA.  36:197-206.

BONE-MINERAL DENSITY OF PREPUBERTAL AGE GIRLS WITH TURNERS-SYNDROME WHILE ON GROWTH-HORMONE THERAPY

OPTIMAL CUTOFF STRATEGIES IN CAPACITY EXPANSION PROBLEMS.  NAVAL RESEARCH LOGISTICS.  42:1021-1039.

OCCULT REJECTION IN RENAL-ALLOGRAFTS - PRECONVERSION BIOPSIES AND POSTCONVERSION REJECTION IN RECIPIENTS CONVERTED FROM CYCLOSPORINE TO AZATHIOPRINE ALONE AT 6 TO 12 MONTHS AFTER TRANSPLANTATION.  TRANSPLANTATION PROCEEDINGS.  26:333-334.

[Need and demand of kidneys for transplantation in Venezuela]..  INVESTIGACION CLINICA.  34:15-27.

IN CHRONIC UREMIA, INSULIN ACTIVATES RECEPTOR KINASE BUT NOT PYRUVATE-DEHYDROGENASE

Comparison of bone mineral content in hypercalciuric and normal children

Increased activity of protein kinase C in renal cortex during phosphate deprivation: Enhacement by parathyroid hormone administration in vivo

EFFECT OF ACIDOSIS ON PTH-DEPENDENT RENAL ADENYLATE-CYCLASE IN PHOSPHORUS DEPRIVATION - ROLE OF G PROTEINS

REGULATION OF 1,25-DIHYDROXYVITAMIN-D3 BY CALCIUM IN THE PARATHYROIDECTOMIZED, PARATHYROID HORMONE-REPLETE RAT

EFFECTS OF CHRONIC METABOLIC ALKALOSIS ON CA-2+, PTH, AND 1,25(OH)2D3 IN THE RAT

OPTIMAL LAYERED SEARCH.  NAVAL RESEARCH LOGISTICS.  36:43-60.

INSULIN BINDING AND GLYCOLYTIC ACTIVITY IN ERYTHROCYTES FROM DIALYZED AND NONDIALYZED UREMIC PATIENTS

EFFECTS OF CADMIUM ON CANINE RENAL CORTICAL ADENYLATE-CYCLASE

MASSIVE CEREBRAL CALCIFICATIONS ASSOCIATED WITH INCREASED RENAL PHOSPHATE REABSORPTION.  ARCHIVES OF INTERNAL MEDICINE.  146:473-477.

EFFECT OF METABOLIC-ACIDOSIS ON THE PTH RECEPTOR-ADENYLATE CYCLASE SYSTEM OF CANINE KIDNEY

DIMENSIONS OF SPACES OF CUSP FORMS OVER FUNCTION-FIELDS.  JOURNAL FUR DIE REINE UND ANGEWANDTE MATHEMATIK.  319:73-103.

EFFECT OF HEMODIALYSIS ON INSULIN-SECRETION BY ISOLATED ISLETS FROM MOUSE PANCREAS

EVIDENCE THAT PARATHYROID-HORMONE IS NOT REQUIRED FOR PHOSPHATE HOMEOSTASIS IN RENAL-FAILURE

EVIDENCE THAT HEMODIALYSIS DOES NOT IMPROVE GLUCOSE-TOLERANCE OF PATIENTS WITH CHRONIC RENAL-FAILURE

NEPHROTIC SYNDROME - COMPLICATION OF MASSIVE OBESITY

EFFECT OF DIALYSIS ON TRUE PLASMA GLUCOSE-TOLERANCE IN UREMIA

PARADOXICAL EFFECT OF CHLORPROPAMIDE ON PLASMA GLUCOSE AND IMMUNOREACTIVE INSULIN-RESPONSE TO INTRAVENOUS GLUCOSE IN NORMAL DOGS

COMPARISON OF EFFECTS OF METABOLIC-ACIDOSIS AND ACUTE UREMIA ON CARBOHYDRATE TOLERANCE

Group therapy in the rehabilitation of the severly aphasic and hemiplegic in the late stages.

Decreased lumbar spine bone mass and low bone turnover in children and adolescents with insulin dependent diabetes mellitus followed longitudinally.  JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM.  11:413-419.

ESTIMATING VISUAL DETECTION PERFORMANCE AT SEA.  OPERATIONS RESEARCH.  36:651-659.

Nephrology in Venezuela.  201-218.

Early Bacteriological Diagnosis of Continuous Ambulatory Peritoneal Dialysis Peritonitis with the Use of a Cytocentrifuge.  223-226.

Response to Exogenous 1,25(OH)2D during a Low-Calcium Diet in Normal Subjects and Idiopathic Renal-Stone Formers.  611-613.

An Ambulatory Metabolic Study of Calcium Urolithiasis in Venezuela.  275-278.

The vitamin D analog paricalcitol (Pc) upregulates osteocyte fibroblast growth factor 23 (FGF23) and improves the mineralization defect in experimental uremia.  BONE. S241-S242.

Possible role of fibroblast growth factor 23 (FGF23) in the pathogenesis of osteodystrophy in end stage kidney disease and renal transplantation.  OSTEOPOROSIS INTERNATIONAL. S72-S72.

The spectrum of renal bone disease in chronic kidney disease (CKD) stages 3 to 5: Possible contribution of osteoporosis.  OSTEOPOROSIS INTERNATIONAL. S76-S77.

Calciuric response to an acute protein load in healthy subjects (C) and hypercalciuric (HQ and normocalciuric (NC) calcium stone formers..  JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 702A-702A.

Effect of iron sucrose (Fe-S) and low molecular weight iron dextran (Fe-D) on endothelial cells (EC)..  JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 872A-872A.

Possible role of fibroblast growth factor 23 (Fgf23) in the pathogenesis of osteodystrophy in end stage kidney disease and renal transplantation..  JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 207A-207A.

Increased osteoblastic activity and expression of bone receptor activator of nuclear factor κB-ligand (RANKL) in non-uremic nephrotic syndrome (NS).  PEDIATRIC RESEARCH. 521A-521A.

Increased expression of bone receptor activator of nuclear factor κB-ligand (RANK-L) in non-azotemic nephrotic syndrome (NS)..  JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 9A-9A.

Increased in vitro stimulation of osteoblastic cells in non-azotemic Nephrotic Syndrome (NS)..  S487-S487.

Inhibition of "in vitro" endothelial cell proliferation induced by iron sucrose..  JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 340A-341A.

One year controlled trial of Pamidronate in the treatment of severe osteopenia after long term renal transplantation..  S387-S387.

Role of hypophosphatemia in osteoblast apoptosis and impaired osteoblastogenesis in post-transplant bone disease. Protective role of PTH..  JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 404A-404A.

Sex steroids and bone mass in male patients on chronic hemodialysis (HD): Positive association with serum estrogens and negative association with androgens..  JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 404A-404A.

Effect of raloxifene, a selective estrogen receptor modulator (SERM), on bone resorption markers and serum lipids in postmenopausal women on chronic hemodialysis (HD).  BONE. S233-S233.

Osteoblastic stimulation and tumor necrosis factor-related activation-induced cytokine (TRANCE) expression in idiopathic hypercalciuria (IH).  BONE. S117-S117.

The pathogenesis of post-transplant (Tx) osteodystrophy as detected by early alterations in bone remodeling..  BONE. S117-S117.

In vitro stimulation of osteoblastic cells in idiopathic hypercalciuria (IH)..  S358-S358.

The effect of raloxifene, a selective estrogen receptor modulator (SERM), on bone resorption markers and serum lipids in postmenopausal women on chronic hemodialysis..  S435-S435.

Decreased trabecular bone mineral density in children with idiopathic short stature. Normalization of bone density and increased bone turnover after one year of growth hormone treatment.  PEDIATRIC RESEARCH. 93A-93A.

Analysis of continuous ambulatory peritoneal dialysis (CAPD) patient's permanence: Patient versus technique survival?.  JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. A0825-A0825.

Bone disease in patients with normal renal function after long-term renal transplantation (RTx)..  JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. A2557-A2557.

Reduced bone mass in asymptomatic mothers and their children with idiopathic hypercalciuria (IH)..  JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. A2567-A2567.

Bone mineral density (BMD) and bone metabolism in children and adolescents with insulin dependent diabetes mellitus (IDDM)..  S652-S652.

Role of the bone in the pathophysiology of idiopathic hypercalciuria: Effect of long term alendronate (ALN) administration..  T694-T694.

A controlled, long term study on the effect of alendronate (ALN) in idiopathic hypercalciuria..  JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. A2697-A2697.

Decreased trabecular bone mineral density (BMD) and hypercalciuria in children and adolescents with insulin dependent diabetes mellitus (IDDM)..  JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. A2722-A2722.

Effect of recombinant human erythropoietin (rHuEPO) on apoptosis in endothelial cells (EC)..  JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. A1548-A1548.

Role of protein kinase (PKC) on the mechanism of PTH resistance in phosphate deprivation..  JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. A2786-A2786.

ROLE OF THE BONE IN THE PATHOGENESIS OF IDIOPATHIC HYPERCALCIURIA - EFFECT OF AMINOBISPHOSPHONATE ALENDRONATE (ALN).  JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 933-933.

IMPORTANCE OF BUN REBOUND (R) IN ASSESSING DIALYSIS PRESCRIPTION.  JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 515-515.

THROMBOMODULIN (TM) LEVELS IN UNTREATED UREMIA (UU), HEMODIALYSIS (HD), AND CHRONIC AMBULATORY PERITONEAL-DIALYSIS (CAPD).  JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 431-431.

COMPARISON OF BONE-MINERAL CONTENT IN HYPERCALCIURIC AND NORMAL-CHILDREN.  KIDNEY INTERNATIONAL. 1421-1422.

VALUE OF THE INTRARENAL PRESSURE DETERMINATION (IRP) IN THE MANAGEMENT OF RENAL-FAILURE AFTER KIDNEY-TRANSPLANTATION.  KIDNEY INTERNATIONAL. 1421-1421.

SOME ASPECTS OF THE PATHOPHYSIOLOGY OF CALCIUM NEPHROLITHIASIS.  61-68.

EFFECTS OF MAGNESIUM ON THE REGULATION OF PARATHYROID HORMONE-DEPENDENT ADENYLATE-CYCLASE.  716-721.

MODULATION OF URINARY CITRATE EXCRETION (UCI) BY PROMOTING FACTORS OF IDIOPATHIC URINARY LITHIASIS.  60-62.

RESISTANCE OF ADENYLATE-CYCLASE (AC) TO PTH DURING PHOSPHATE DEPRIVATION (PD) IS ASSOCIATED TO DECREASED ACTIVITY OF THE STIMULATORY SIGNAL TRANSDUCING GS.  KIDNEY INTERNATIONAL. 463-463.

SLOWER PROGRESSION OF BONE MASS-LOSS ON CONTINUOUS AMBULATORY PERITONEAL-DIALYSIS (CAPD) AS COMPARED TO CHRONIC-HEMODIALYSIS (HD).  KIDNEY INTERNATIONAL. 334-334.

PATHOGENESIS, MEDICAL-TREATMENT AND PREVENTION OF CALCIUM-OXALATE RENAL STONES.  107-110.

PHARMACOLOGICAL AND NONPHARMACOLOGICAL REGULATION OF SODIUM-PHOSPHATE COTRANSPORT IN THE KIDNEY.  125-128.

RESPONSE TO EXOGENOUS 1,25(OH)2 D3 (1,25D) IN IDIOPATHIC RENAL STONE FORMERS.  KIDNEY INTERNATIONAL. 400-400.

ERYTHROPOIESIS AND ERYTHROPOIETIN BLOOD-LEVELS (EP) IN RATS WITH RENAL-FAILURE (RF) AND INDUCED ANEMIA.  KIDNEY INTERNATIONAL. 372-372.

METABOLIC-ACIDOSIS (MA) ENHANCES THE RESISTANCE OF CANINE RENAL CORTICAL ADENYLATE-CYCLASE (AC) TO PARATHYROID-HORMONE (PTH) DURING DIETARY PHOSPHORUS DEPRIVATION (PD).  KIDNEY INTERNATIONAL. 335-335.

RESPONSE TO EXOGENOUS 1,25(OH)2 VITAMIN-D3 (1,25D) UNDER A LOW-CALCIUM DIET IN NORMAL CONTROLS AND IDIOPATHIC RENAL STONE FORMERS.  202-203.

INTERACTION OF CADMIUM (CD++) WITH THE PTH-ADENYLATE CYCLASE (AC) SYSTEM IN BASOLATERAL CORTICAL MEMBRANES OF CANINE KIDNEY.  KIDNEY INTERNATIONAL. 173-173.

REGULATION OF SERUM 1,25(OH)2D3 BY IONIZED CALCIUM DURING CONSTANT PHYSIOLOGICAL REPLACEMENT OF PARATHYROID-HORMONE IN THE PARATHYROIDECTOMIZED RAT.  KIDNEY INTERNATIONAL. 360-360.

IONIZED CALCIUM REGULATES SERUM 1,25(OH)2D3 DURING CONSTANT PHYSIOLOGICAL REPLACEMENT OF PARATHYROID-HORMONE IN THE PARATHYROID-ECTOMIZED RAT.  A967-A967.

EFFECT OF CADMIUM ON THE ADENYLATE-CYCLASE SYSTEM OF CANINE KIDNEY.  A602-A602.

RELATIONSHIP BETWEEN GLYCOLYTIC ACTIVITY IN ERYTHROCYTES AND GLUCOSE-INTOLERANCE IN UREMIA (U), HEMODIALYSIS(HD), AND CONTINUOUS AMBULATORY PERITONEAL DIALYSIS (CAPD).  KIDNEY INTERNATIONAL. 243-243.

PROSPECTIVE AMBULATORY METABOLIC STUDY OF IDIOPATHIC CALCIUM NEPHROLITHIASIS IN VENEZUELA.  31-31.

EFFECT OF PARATHYROID-HORMONE (PTH) REDUCTION BY CIMETIDINE ON THE GLUCOSE-INTOLERANCE OF UREMIA.  KIDNEY INTERNATIONAL. 217-217.

INSULIN-SECRETION FROM ISOLATED ISLETS CELLS OBTAINED FROM UREMIC RATS.  KIDNEY INTERNATIONAL. 228-228.

INSULIN-SECRETION FROM ISOLATED PANCREATIC-ISLETS OBTAINED FROM UREMIC RATS.  A465-A465.

EFFECT OF UREMIA ON INSULIN-SECRETION BY ISOLATED PANCREATIC-ISLETS.  86-86.

COMPARATIVE EFFECTS OF HEMODIALYSIS AND PERITONEAL-DIALYSIS ON GLUCOSE-INTOLERANCE IN UREMIA.  64-64.

EFFECT OF HEMODIALYSIS ON INSULIN-SECRETION FROM ISOLATED PANCREATIC-ISLETS CELLS.  KIDNEY INTERNATIONAL. 493-493.

EFFECT OF HEMODIALYSIS ON INSULIN-SECRETION INVITRO OF ISOLATED MOUSE PANCREATIC-ISLETS.  77-77.

Renal function and bisphosphonate safety.  453-454.

Magnesium and phosphorus -: Reply.  LANCET. 1475-1476.

CLINICAL AND HISTOLOGICAL KIDNEY INVOLVEMENT IN HUMAN KALAAZAR.  AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 357-359.

THE COMPLEXITY OF THE OPTIMAL SEARCHER PATH PROBLEM.  OPERATIONS RESEARCH. 324-327.

Abdominal Pain in a Patient with Asymmetry.  314-315.

Clinical practice guidelines for the prevention, diagnosis, evaluation and treatment of mineral and bone disorders in chronic kidney disease (CKD-MBD) in adults..  1-28.

KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD)..  S1-130.

Bone mineral density in idiopathic hypercalciuria: The chicken or the egg?.  C81-C82.

New insights into the pathogenesis of idiopathic hypercalciuria: The role of bone.  KIDNEY INTERNATIONAL. 1507-1518.

[Safety in the switching traditional cyclosporin to microemulsion cyclosporin in stable renal transplant patients: cooperative study]..  INVESTIGACION CLINICA. 183-196.

Massive cerebral calcifications associated with increased renal phosphate reabsorption..  ARCHIVES OF INTERNAL MEDICINE. 473-477.

Insulin and glucose metabolism in renal insufficiency..  63-69.

Introduction and definition of CKD-MBD and the development of the guideline statements.  KIDNEY INTERNATIONAL. S3-S130.

Bone disease after renal transplantation.  1300-1313.

Bone disease in idiopathic hypercalciuria.  394-402.

Postmenopausal osteoporosis in the dialysis patient.  381-386.

A SURVEY OF THE SEARCH THEORY LITERATURE.  NAVAL RESEARCH LOGISTICS. 469-494.