Overview
biography
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After receiving his bachelor’s degree in pharmacy from the University of Saskatchewan, Dr. Kim Tieu practiced as a pharmacist for several years. During this time, he also secured a scholarship to join a doctoral program at the University of Saskatchewan to investigate a series of newly developed compounds, known as propargylamines, for the treatment of Parkinson’s disease (PD) and other neurological disorders. He subsequently left Canada to accept a postdoctoral position at Columbia University to further develop his expertise in PD research. In 2004 Dr. Tieu was recruited by the Department of Environmental Medicine at the University of Rochester Medical Center to establish his independent research laboratory. In Rochester, his laboratory received funding supports from the National Institute of Environmental Health Sciences (NIEHS) to investigate the novel pathogenic mechanisms mediated by glia-neuron interactions, gene-environment interactions and imbalanced mitochondrial fission/fusion in PD. In 2012 Dr. Tieu was recruited by Plymouth University in England to establish a research program in PD. Recognizing his significant and translational research, both the NIH and the UK Medical Research Council funded his laboratory to investigate the role of mitochondrial dynamics in PD.
Dr. Tieu was recruited back to the U.S. to join the Department of Environmental Health Sciences at the Florida International University in 2016. His lab has been awarded the NIEHS Revolutionizing Innovative, Visionary Environmental Health Research (RIVER) grant after discovering a new function of a protein that could be targeted as potential therapeutics for neurological disorders such as Parkinson’s disease.
research interests
- Pathogenic mechanisms and therapeutic strategies for Parkinson’s disease
Scholarly & Creative Works
selected scholarly works & creative activities
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Article
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2024A partial Drp1 knockout improves autophagy flux independent of mitochondrial functionFull Text via DOI: 10.1186/s13024-024-00708-w Web of Science: 001187770900001
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2024Mitochondrial hyperfusion induces metabolic remodeling in lung endothelial cells by modifying the activities of electron transport chain complexes I and III. FREE RADICAL BIOLOGY AND MEDICINE. 210:183-194.Full Text via DOI: 10.1016/j.freeradbiomed.2023.11.008 Web of Science: 001129100700001
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2023Metabolic reprogramming, oxidative stress, and pulmonary hypertension. REDOX BIOLOGY. 64.Full Text via DOI: 10.1016/j.redox.2023.102797 Web of Science: 001037064800001
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2023Nitration-mediated activation of the small GTPase RhoA stimulates cellular glycolysis through enhanced mitochondrial fissionFull Text via DOI: 10.1016/j.jbc.2023.103067 Web of Science: 001006729100001
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2022Loss of SOX18/CLAUDIN5 disrupts the pulmonary endothelial barrier in ventilator-induced lung injuryFull Text via DOI: 10.3389/fphys.2022.1066515 Web of Science: 000907807400001
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2022Abstract 13625: Autophagy Plays a Key Role in the Loss of Nitric Oxide Signaling and Endothelial Dysfunction in Pulmonary Vascular Diseases. CIRCULATION. 146:a13625-a13625.Full Text via DOI: 10.1161/circ.146.suppl_1.13625
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2022Abstract 14973: Upregulated Sphingosine-1-Phosphate Receptor 3 Disrupts Endothelial Cell Barrier and Mitochondrial Network Dynamics. CIRCULATION. 146:a14973-a14973.Full Text via DOI: 10.1161/circ.146.suppl_1.14973
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2022Sex and APOE Genotype Alter the Basal and Induced Inflammatory States of Primary Microglia from APOE Targeted Replacement MiceFull Text via DOI: 10.3390/ijms23179829 Web of Science: 000851083600001
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2022
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2020Microglial exosomes facilitate α-synuclein transmission in Parkinson's disease. BRAIN. 143:1476-1497.Full Text via DOI: 10.1093/brain/awaa090 Web of Science: 000541777000028
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2019Exosome release and neuropathology induced by α-synuclein: new insights into protective mechanisms of Drp1 inhibition. ACTA NEUROPATHOLOGICA COMMUNICATIONS. 7.Full Text via DOI: 10.1186/s40478-019-0821-4 Web of Science: 000509586300001
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2017PINK1 signalling rescues amyloid pathology and mitochondrial dysfunction in Alzheimer's disease. BRAIN. 140:3233-3251.Full Text via DOI: 10.1093/brain/awx258 Web of Science: 000417337600024
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2017Mitochondrial division inhibitor-1 is neuroprotective in the A53T-α-synuclein rat model of Parkinson's disease. SCIENTIFIC REPORTS. 7.Full Text via DOI: 10.1038/s41598-017-07181-0 Web of Science: 000407179800013
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2016Blocking mitochondrial fission is protective in dopaminergic neuronal cells with inducible α-synuclein expression. PARKINSONISM & RELATED DISORDERS. 22:e191.Full Text via DOI: 10.1016/j.parkreldis.2015.10.492
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2015Local anesthetics induce autophagy in young permanent tooth pulp cellsFull Text via DOI: 10.1038/cddiscovery.2015.24 Web of Science: 000463069500017
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2014Drp1 inhibition attenuates neurotoxicity and dopamine release deficits in vivo. NATURE COMMUNICATIONS. 5.Full Text via DOI: 10.1038/ncomms6244 Web of Science: 000345653100001
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2013Impaired Mitochondrial Dynamics and Nrf2 Signaling Contribute to Compromised Responses to Oxidative Stress in Striatal Cells Expressing Full-Length Mutant Huntingtin. PLOS ONE. 8.Full Text via DOI: 10.1371/journal.pone.0057932 Web of Science: 000315897100050
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2012Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activity. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 109:6265-6270.Full Text via DOI: 10.1073/pnas.1120997109 Web of Science: 000303246100072
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20123.106 PARAQUAT NEUROTOXICITY IS MEDIATED BY THE DOPAMINE TRANSPORTER AND ORGANIC CATION TRANSPORTER-3. PARKINSONISM & RELATED DISORDERS. 18:s190-s191.Full Text via DOI: 10.1016/s1353-8020(11)70824-0
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20123.246 BLOCKING DRP-1 FUNCTION IS NEUROPROTECTIVE IN ANIMAL MODELS OF PARKINSON'S DISEASE. PARKINSONISM & RELATED DISORDERS. 18:s215.Full Text via DOI: 10.1016/s1353-8020(11)70918-x
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20123.260 D-β-HYDROXYBUTYRATE IS NEUROPROTECTIVE IN MOUSE MODELS OF HUNTINGTON'S DISEASE. PARKINSONISM & RELATED DISORDERS. 18:s218.Full Text via DOI: 10.1016/s1353-8020(11)70931-2
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2011Paraquat neurotoxicity is mediated by the dopamine transporter and organic cation transporter-3. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 108:20766-20771.Full Text via DOI: 10.1073/pnas.1115141108 Web of Science: 000298289400098
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2011D-β-Hydroxybutyrate Is Protective in Mouse Models of Huntington's Disease. PLOS ONE. 6.Full Text via DOI: 10.1371/journal.pone.0024620 Web of Science: 000294803200032
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2011A Guide to Neurotoxic Animal Models of Parkinson's DiseaseFull Text via DOI: 10.1101/cshperspect.a009316 Web of Science: 000208623800010
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2010Neurosteroid transport by the organic solute transporter OST alpha-OST beta. JOURNAL OF NEUROCHEMISTRY. 115:220-233.Full Text via DOI: 10.1111/j.1471-4159.2010.06920.x Web of Science: 000281828200021
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2010Adenosine A1 receptors mediate local anti-nociceptive effects of acupunctureFull Text via DOI: 10.1038/nn.2562 Web of Science: 000279173900022
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2010PINK1-dependent recruitment of Parkin to mitochondria in mitophagy. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 107:378-383.Full Text via DOI: 10.1073/pnas.0911187107 Web of Science: 000273559200066
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2010Adenosine A1 receptors mediate local anti-nociceptive effects of acupunctureFull Text via DOI: 10.1016/j.dza.2010.08.001 Web of Science: 000421595000009
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2009The organic cation transporter-3 is a pivotal modulator of neurodegeneration in the nigrostriatal dopaminergic pathway. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 106:8043-8048.Full Text via DOI: 10.1073/pnas.0900358106 Web of Science: 000266208900066
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2005Complex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damage. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 102:19126-19131.Full Text via DOI: 10.1073/pnas.0508215102 Web of Science: 000234350000062
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2005Ablation of the inflammatory enzyme myeloperoxidase mitigates features of Parkinson's disease in mice. JOURNAL OF NEUROSCIENCE. 25:6594-6600.Full Text via DOI: 10.1523/JNEUROSCI.0970-05.2005 Web of Science: 000230478100012
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2004MPTP as a mitochondrial neurotoxic model of Parkinson's diseaseFull Text via DOI: 10.1023/B:JOBB.0000041771.66775.d5 Web of Science: 000223916300020
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2004L-3-hydroxyacyl-CoA dehydrogenase II protects in a model of Parkinson's disease. ANNALS OF NEUROLOGY. 56:51-60.Full Text via DOI: 10.1002/ana.20133 Web of Science: 000222425600008
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2003D-β-hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson diseaseFull Text via DOI: 10.1172/JCI200318797 Web of Science: 000185376400013
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2003NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 100:6145-6150.Full Text via DOI: 10.1073/pnas.0937239100 Web of Science: 000182939400103
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2003Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 100:5473-5478.Full Text via DOI: 10.1073/pnas.0837397100 Web of Science: 000182612600091
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2003
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2002Glial cell response: A pathogenic factor in Parkinson's disease. JOURNAL OF NEUROVIROLOGY. 8:551-558.Full Text via DOI: 10.1080/13550280290100905 Web of Science: 000180306600009
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2002Resistance of α-synuclein null mice to the parkinsonian neurotoxin MPTP. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 99:14524-14529.Full Text via DOI: 10.1073/pnas.172514599 Web of Science: 000178967400099
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2002Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease. JOURNAL OF NEUROSCIENCE. 22:1763-1771.Full Text via DOI: 10.1523/JNEUROSCI.22-05-01763.2002 Web of Science: 000174192500030
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2001The role of glial cells in Parkinson's disease. CURRENT OPINION IN NEUROLOGY. 14:483-489.Full Text via DOI: 10.1097/00019052-200108000-00009 Web of Science: 000170327900009
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2001Inhibition of 6-hydroxydopamine-induced p53 expression and survival of neuroblastoma cells following interaction with astrocytes. NEUROSCIENCE. 103:125-132.Full Text via DOI: 10.1016/S0306-4522(00)00565-0 Web of Science: 000167494600012
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1998
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Book Chapter
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2022Cognitive impact of exposure to airborne particles captured by brain imaging. 29-45.Full Text via DOI: 10.1016/bs.ant.2022.05.002
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2017Chapter Eight Mitochondrial Dynamics in Neurodegenerative Diseases. 211-246.Full Text via DOI: 10.1016/bs.ant.2017.07.006
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2017Mitochondrial Dynamics in Neurodegenerative Diseases. 211-246.Full Text via DOI: 10.1016/bs.ant.2017.07.006 Web of Science: 000424949900009
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2015Organic cation transporters as modulators of neurodegeneration and neuroprotection in the brain. 205-216.Full Text via DOI: 10.1007/978-3-319-23793-0_8
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2014Chapter 3 - Principles of Mitophagy and Beyond. 65-83.Full Text via DOI: 10.1016/B978-0-12-405528-5.00003-1
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Conference
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2022
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2022
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2020Oxidative DNA Damage in Parkinson's Disease-Associated Genes.. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 75-75.Web of Science: 000571638700166
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2010ADENOSINE A1 RECEPTORS MEDIATE LOCAL ANTI-NOCICEPTIVE EFFECTS OF ACUPUNCTURE. JOURNAL OF NEUROCHEMISTRY. 76-76.Web of Science: 000281812600199
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2010Acupuncture induces release of adenine nucleotides and adensoine. 69-69.Web of Science: 000280241700148
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2010The analgesic effect of acupuncture is mediated by adenosine A1 receptors. 161-162.Web of Science: 000280241700338
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2009Mitochondrial defects induced by a loss of fusion effect in mutant PINK1 can be rescued through the fission/fusion pathway. PARKINSONISM & RELATED DISORDERS. S174-S174.Full Text via DOI: 10.1016/S1353-8020(09)70666-2 Web of Science: 000576194500652
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2006Involvement of PI3-K/Akt signal pathway in acquired resistance against 6-OHDA in SH-SY5Ycell following interaction with astrocytes. JOURNAL OF NEUROCHEMISTRY. 61-61.Web of Science: 000235982900163
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2003COX-2 and neurodegeneration in Parkinson's disease. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 272-277.Web of Science: 000184302100025
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2001Suppresion of p53 expression and increase in survival of SH-SY5Y cells in response to 6-hydroxydopamine in astrocytes cocultures. JOURNAL OF NEUROCHEMISTRY. 83-83.Web of Science: 000170789800293
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1997Effects of staurosporine and retinoic acid on the vulnerability of SH-SY5Y neuroblastoma cells to of bcl-2 and p53 genes.. JOURNAL OF NEUROCHEMISTRY. S137-S137.Web of Science: A1997XM28500537
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Note
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2010Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture. 38-39.Full Text via DOI: 10.1016/j.dza.2010.08.002
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Other Scholarly Work
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2022Mitochondrial Hyperfusion Disrupts Carbohydrate Metabolism In Lung Endothelial Cells By Modifying The Activities Of Electron Transport Chain Complexes I And III. FREE RADICAL BIOLOGY AND MEDICINE.Full Text via DOI: 10.1016/j.freeradbiomed.2022.10.170 Web of Science: 000895512500183
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2022Mitochondrial redistribution of eNOS is regulated by CHIP mediated disruption of Dimerization. FREE RADICAL BIOLOGY AND MEDICINE.Full Text via DOI: 10.1016/j.freeradbiomed.2022.10.124 Web of Science: 000895512500134
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2022NAMPT induces Mitochondrial and Barrier Dysfunction in Pulmonary Endothelial Cells. FREE RADICAL BIOLOGY AND MEDICINE.Full Text via DOI: 10.1016/j.freeradbiomed.2022.10.116 Web of Science: 000895512500126
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2022S1PR3 Plays a Key Role in Ventilator-induced Lung Injury: Promoter Activation, Barrier Disruption, and Therapeutic Evaluation. FREE RADICAL BIOLOGY AND MEDICINE.Full Text via DOI: 10.1016/j.freeradbiomed.2022.10.309 Web of Science: 000895512500140
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2022Systemic effect of NF-kB-mediated Signaling Pathway Induced by Mechanosensitive Ca2+-Channel TRPV4 in Pulmonary Endothelial Cells. FREE RADICAL BIOLOGY AND MEDICINE.Full Text via DOI: 10.1016/j.freeradbiomed.2022.10.089 Web of Science: 000895512500099
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2022The anti-apoptotic protein, Survivin induces a shift in endothelial cell in carbon metabolism through a mitochondrial-ROS-dependent increase in HIF-1a signaling. FREE RADICAL BIOLOGY AND MEDICINE.Full Text via DOI: 10.1016/j.freeradbiomed.2022.10.109 Web of Science: 000895512500119
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2014Cytosolic PINK1 escapes form mitochondria to promote dendritic outgrowth. JOURNAL OF NEUROCHEMISTRY. 787-789.Full Text via DOI: 10.1111/jnc.12529 Web of Science: 000332347300001
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2012Cultured astrocytes do not release adenosine during hypoxic conditions. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. E1-E7.Full Text via DOI: 10.1038/jcbfm.2011.142 Web of Science: 000299010000001
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2004Pathogenic role of glial cells Parkinson's disease (vol 18, pg 121, 2003). 118-118.Full Text via DOI: 10.1002/mds.10701 Web of Science: 000188210900027
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Preprint
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Review
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2023Manganese-Induced Parkinsonism: Evidence from Epidemiological and Experimental StudiesFull Text via DOI: 10.3390/biom13081190 Web of Science: 001056193000001
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2021Exosomes in Parkinson disease. JOURNAL OF NEUROCHEMISTRY. 413-428.Full Text via DOI: 10.1111/jnc.15288 Web of Science: 000609916700001
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2017Mitochondria: A Common Target for Genetic Mutations and Environmental Toxicants in Parkinson's DiseaseFull Text via DOI: 10.3389/fgene.2017.00177 Web of Science: 000415602000001
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2017Tipping Points and Endogenous Determinants of Nigrostriatal Degeneration by MPTP. TRENDS IN PHARMACOLOGICAL SCIENCES. 541-555.Full Text via DOI: 10.1016/j.tips.2017.03.010 Web of Science: 000401516500006
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2010Astrocytes and Therapeutics for Parkinson's Disease. 413-423.Full Text via DOI: 10.1016/j.nurt.2010.07.001 Web of Science: 000282198500008
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2009Glutathione dysregulation and the etiology and progression of human diseases. 191-214.Full Text via DOI: 10.1515/BC.2009.033 Web of Science: 000264921500001
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2003Nitric oxide and reactive oxygen species in Parkinson's disease. IUBMB LIFE. 329-335.Full Text via DOI: 10.1080/1521654032000114320 Web of Science: 000184460000007
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2003Pathogenic role of glial cells in Parkinson's disease. 121-129.Full Text via DOI: 10.1002/mds.10332 Web of Science: 000181007900001
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Research
principal investigator on
co-principal investigator on
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Grant
- COR: Training in Environmental Neuroscience awarded by Environmental Health Sciences 2023 - 2028
Contact
full name
- Kim Tieu
Identifiers
ORCID iD
- https://orcid.org/0000-0001-6606-4371 (confirmed)
visualizations
publication subject areas
Citation index-derived subject areas the researcher has published in