Roy, Deodutta

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Roy, Deodutta

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Professor, Environmental Health Sciences , Robert Stempel College of Public Health and Social Work

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selected scholarly works & creative activities

Article
- 2023
  
  Endocrine Disrupting Chemicals Influence Hub Genes Associated with Aggressive Prostate Cancer
  Full Text via DOI: 10.3390/ijms24043191 Web of Science: 000939034100001
- 2022
  
  Brain infiltration of breast cancer stem cells is facilitated by paracrine signaling by inhibitor of differentiation 3 to nuclear respiratory factor 1. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY. 148:2881-2891.
  Full Text via DOI: 10.1007/s00432-022-04026-w Web of Science: 000808418200001
- 2022
  
  Nuclear respiratory factor 1 transcriptomic signatures as prognostic indicators of recurring aggressive mesenchymal glioblastoma and resistance to therapy in White American females. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY. 148:1641-1682.
  Full Text via DOI: 10.1007/s00432-022-03987-2 Web of Science: 000784837600002
- 2022
  
  Abstract 1442: Discovery of recurrence and prognosis associated genes in prostate cancer. CANCER RESEARCH. 82:1442-1442.
  Full Text via DOI: 10.1158/1538-7445.am2022-1442
- 2022
  
  Abstract 779: A NRF1-driven JRK-mediated β-catenin transcriptional activity contributes to the aggressive growth of ovarian cancer. CANCER RESEARCH. 82:779-779.
  Full Text via DOI: 10.1158/1538-7445.am2022-779
- 2022
  
  A Better Mechanistic Understanding of Big Data through an Order Search Using Causal Bayesian Networks
  Full Text via DOI: 10.3390/bdcc6020056 Web of Science: 000816386200001
- 2022
  
  Environmental Phenol and Paraben Exposure Risks and Their Potential Influence on the Gene Expression Involved in the Prognosis of Prostate Cancer
  Full Text via DOI: 10.3390/ijms23073679 Web of Science: 000781204300001
- 2021
  
  Is Mycobacterium tuberculosis carcinogenic to humans?. FASEB JOURNAL. 35.
  Full Text via DOI: 10.1096/fj.202001581RR Web of Science: 000691122900023
- 2021
  
  The M. tuberculosis Rv1523 Methyltransferase Promotes Drug Resistance Through Methylation-Mediated Cell Wall Remodeling and Modulates Macrophages Immune Responses
  Full Text via DOI: 10.3389/fcimb.2021.622487
- 2021
  
  Computational modeling and bioinformatic analyses of functional mutations in drug target genes in Mycobacterium tuberculosis
  Full Text via DOI: 10.1016/j.csbj.2021.04.034 Web of Science: 000692620700012
- 2020
  
  Causal Bayesian gene networks associated with bone, brain and lung metastasis of breast cancer. CLINICAL & EXPERIMENTAL METASTASIS. 37:657-674.
  Full Text via DOI: 10.1007/s10585-020-10060-0 Web of Science: 000580404900001
- 2020
  
  Sensitivity to differential NRF1 gene signatures contributes to breast cancer disparities. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY. 146:2777-2815.
  Full Text via DOI: 10.1007/s00432-020-03320-9 Web of Science: 000551783900003
- 2020
  
  Nuclear Respiratory Factor 1 (NRF1) Transcriptional Activity-Driven Gene Signature Association with Severity of Astrocytoma and Poor Prognosis of Glioblastoma. MOLECULAR NEUROBIOLOGY. 57:3827-3845.
  Full Text via DOI: 10.1007/s12035-020-01979-2 Web of Science: 000544199400001
- 2018
  
  Nuclear Respiratory Factor 1 Acting as an Oncoprotein Drives Estrogen-Induced Breast Carcinogenesis
  Full Text via DOI: 10.3390/cells7120234 Web of Science: 000455320700012
- 2018
  
  NRF1 motif sequence-enriched genes involved in ER/PR -ve HER2+ve breast cancer signaling pathways. BREAST CANCER RESEARCH AND TREATMENT. 172:469-485.
  Full Text via DOI: 10.1007/s10549-018-4905-9 Web of Science: 000447497300021
- 2017
  
  Environmental estrogen-like endocrine disrupting chemicals and breast cancer. MOLECULAR AND CELLULAR ENDOCRINOLOGY. 457:89-102.
  Full Text via DOI: 10.1016/j.mce.2016.10.003 Web of Science: 000413128000011
- 2017
  
  Abstract 938: Estrogen induced NRF1 signaling is a molecular mechanism underlying the generation of different breast cancer stem cell subpopulations leading to intratumoral heterogeneity. CANCER RESEARCH. 77:938-938.
  Full Text via DOI: 10.1158/1538-7445.am2017-938
- 2016
  
  Abstract 3312: Transcriptional regulation of chemokine receptor 4 (CXCR4) by nuclear respiratory factor 1 (NRF1) controls estrogen-induced malignant transformation of breast epithelial cells to breast cancer stem cells. CANCER RESEARCH. 76:3312-3312.
  Full Text via DOI: 10.1158/1538-7445.am2016-3312
- 2016
  
  Use of Bioinformatics in Revealing the Identity of Nature’s Products with Minimum Genetic Variation: The Sibling Species
  Full Text via DOI: 10.1201/b19969-6
- 2016
  
  Association between Exposure to Estrogenic Endocrine Disruptors - Polychlorinated Biphenyls, Phthalates, and Bisphenol A and Gynecologic Cancers- Cervical, Ovarian, Uterine Cancers
  Full Text via DOI: 10.4172/2157-2518.1000275
- 2015
  
  Proteomic and Mitochondrial Genomic Analyses of Pediatric Brain Tumors. MOLECULAR NEUROBIOLOGY. 52:1341-1363.
  Full Text via DOI: 10.1007/s12035-014-8930-3 Web of Science: 000361903400023
- 2015
  
  Integrated Bioinformatics, Environmental Epidemiologic and Genomic Approaches to Identify Environmental and Molecular Links between Endometriosis and Breast Cancer
  Full Text via DOI: 10.3390/ijms161025285 Web of Science: 000364232100114
- 2015
  
  Redox signalling to nuclear regulatory proteins by reactive oxygen species contributes to oestrogen-induced growth of breast cancer cells. BRITISH JOURNAL OF CANCER. 112:1687-1702.
  Full Text via DOI: 10.1038/bjc.2014.586 Web of Science: 000354376500009
- 2014
  
  Bayesian Network and Mechanistic Hierarchical Structure Modeling of Increased likelihood of Developing Intractable Childhood Epilepsy from the Combined Effect of mtDNA Variants, Oxidative Damage, and Copy Number. JOURNAL OF MOLECULAR NEUROSCIENCE. 54:752-766.
  Full Text via DOI: 10.1007/s12031-014-0364-x Web of Science: 000345995700018
- 2014
  
  INCREASED RISK OF CHILDHOOD BRAIN TUMORS AMONG CHILDREN WHOSE PARENTS HAD FARM-RELATED PESTICIDE EXPOSURES DURING PREGNANCY
  Web of Science: 000450099900001
- 2013
  
  Reverse Engineering of Modified Genes by Bayesian Network Analysis Defines Molecular Determinants Critical to the Development of Glioblastoma. PLOS ONE. 8.
  Full Text via DOI: 10.1371/journal.pone.0064140 Web of Science: 000321394700034
- 2013
  
  Discovering gene-environment interactions in Glioblastoma through a comprehensive data integration bioinformatics method. NEUROTOXICOLOGY. 35:1-14.
  Full Text via DOI: 10.1016/j.neuro.2012.11.001 Web of Science: 000316777200001
- 2013
  
  Reactive Oxygen Species via Redox Signaling to PI3K/AKT Pathway Contribute to the Malignant Growth of 4-Hydroxy Estradiol-Transformed Mammary Epithelial Cells. PLOS ONE. 8.
  Full Text via DOI: 10.1371/journal.pone.0054206 Web of Science: 000315186000002
- 2012
  
  Identification of the Mechanisms Underlying Antiestrogen Resistance: Breast Cancer Research Partnership between FIU-UM Braman Family Breast Cancer Institute
  Full Text via DOI: 10.21236/ada566229
- 2011
  
  IL1B (interleukin 1, beta)
  Full Text via DOI: 10.4267/2042/44449
- 2011
  
  Identification of the Mechanisms Underlying Antiestrogen Resistance: Breast Cancer Research Partnership Between FIU-UM Braman Family Breast Cancer Institute
  Full Text via DOI: 10.21236/ada549249
- 2010
  
  Inhibition of Estrogen-Induced Growth of Breast Cancer by Targeting Mitochondria Oxidants
  Full Text via DOI: 10.21236/ada530428
- 2008
  
  Identification of the Mechanisms Underlying Antiestrogen Resistance: Breast Cancer Research Partnership between FIU-UM Braman Family Breast Cancer Institute
  Full Text via DOI: 10.21236/ada488580
- 2008
  
  Allelic loss and mutations in a new ETRG-1 gene are early events in diethylstilbestrol-induced renal carcinogenesis in Syrian hamsters. GENE. 408:18-26.
  Full Text via DOI: 10.1016/j.gene.2007.10.022 Web of Science: 000253033600003
- 2007
  
  Is In Utero Imprinting of the Brain by Pesticides Involved in Childhood Brain Cancer Development?. EPIDEMIOLOGY. 18:s169-s170.
  Full Text via DOI: 10.1097/01.ede.0000276854.53888.a7
- 2006
  
  Development of a self-proliferating Leydig cell line: A hyper-sensitive E-screening model. ONCOLOGY REPORTS. 16:73-77.
  Web of Science: 000238520400010
- 2006
  
  SKCG-1: a new candidate growth regulatory gene at chromosome 11q23.2 in human sporadic Wilms tumours. BRITISH JOURNAL OF CANCER. 94:1524-1532.
  Full Text via DOI: 10.1038/sj.bjc.6603090 Web of Science: 000237648200026
- 2006
  
  Estrogen exerts a spatial and temporal influence on reactive oxygen species generation that precedes calcium uptake in high-capacity mitochondria: Implications for rapid nongenomic signaling of cell growth. BIOCHEMISTRY. 45:2872-2881.
  Full Text via DOI: 10.1021/bi051855x Web of Science: 000235792500013
- 2006
  
  Levels of IL-1 beta control stimulatory/inhibitory growth of cancer cells. FRONTIERS IN BIOSCIENCE. 11:889-898.
  Full Text via DOI: 10.2741/1845 Web of Science: 000232528000071
- 2005
  
  Estrogen-induced G₁/S transition of G₀-arrested estrogen-dependent breast cancer cells is regulated by mitochondrial oxidant signaling. ONCOGENE. 24:4883-4893.
  Full Text via DOI: 10.1038/sj.onc.1208667 Web of Science: 000230646500002
- 2005
  
  Estrogen-induced mitochondrial reactive oxygen species as signal-transducing messengers. BIOCHEMISTRY. 44:6900-6909.
  Full Text via DOI: 10.1021/bi047629p Web of Science: 000228962500019
- 2005
  
  Mitochondrial signals to nucleus regulate estrogen-induced cell growth. MEDICAL HYPOTHESES. 64:133-141.
  Full Text via DOI: 10.1016/j.mehy.2003.12.056 Web of Science: 000225481400031
- 2004
  
  Somatic mutations in stilbene estrogen-induced Syrian hamster kidney tumors identified by DNA fingerprinting
  Full Text via DOI: 10.1186/1477-3163-3-4
- 2004
  
  Age, sex and co-exposure to N-ethyl-N-nitrosourea influence mutations in the Alu repeat sequences in diethylstilbestrol-induced kidney tumors in Syrian hamsters
  Full Text via DOI: 10.1093/mutage/geh003
- 2001
  
  Regulation of the growth of mouse Ley dig cells by the inactive stereoisomer, 17α-estradiol: Lack of correlation between the elevated expression of ERa and difference in sensitivity to estradiol isomers. ONCOLOGY REPORTS. 8:899-902.
- 2001
  
  Occupational exposure to endocrine-disrupting pesticides and the potential for developing hormonal cancers. JOURNAL OF ENVIRONMENTAL HEALTH. 64:17-29.
- 2001
  
  The inhibition of DNA repair capacity by stilbene estrogen in Leydig cells: Its implications in the induction of instability in the testicular genome
  Full Text via DOI: 10.1016/S0027-5107(01)00222-6
- 2001
  
  Identification of novel breast tumor-specific mutation(s) in the q11.2 region of chromosome 17 by RAPD/AP-PCR fingerprinting. GENE. 269:33-43.
  Full Text via DOI: 10.1016/S0378-1119(01)00458-9
- 2001
  
  Base sequence-specific attack of stilbene estrogen metabolite(s) on the mitochondrial DNA: implications in the induction of instability in the mitochondrial genome in the kidney of Syrian hamsters.. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 7:389-395.
  Full Text via DOI: 10.3892/ijmm.7.4.389
- 2001
  
  The biphasic stimulation of proliferation of Leydig cells by estrogen exposure.. INTERNATIONAL JOURNAL OF ONCOLOGY. 18:623-628.
  Full Text via DOI: 10.3892/ijo.18.3.623
- 1999
  
  Estrogen, DNA damage and mutations
  Full Text via DOI: 10.1016/S0027-5107(99)00012-3
- 1999
  
  Detection of mutation(s) or polymorphic loci in the genome of experimental animal and human cancer tissues by RAPD/AP-PCR depend on DNA polymerase. INTERNATIONAL JOURNAL OF ONCOLOGY. 14:753-758.
  Full Text via DOI: 10.3892/ijo.14.4.753
- 1998
  
  Concentration dependence of prooxidant and antioxidant properties of catecholestrogens. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 360:105-112.
  Full Text via DOI: 10.1006/abbi.1998.0934
- 1998
  
  Metabolism and fate of xeno-oestrogens in man
  Full Text via DOI: 10.1351/pac199870091747
- 1998
  
  Pro-oxidant and antioxidant effects of estrogens.
  Full Text via DOI: 10.1385/0-89603-472-0:425
- 1997
  
  Estrogen-nucleic acid adducts: Guanine is major site for interaction between 3,4-estrone quinone and COIII gene. CARCINOGENESIS. 18:1247-1249.
  Full Text via DOI: 10.1093/carcin/18.6.1247
- 1997
  
  Biochemical and molecular changes at the cellular level in response to exposure to environmental estrogen-like chemicals
  Full Text via DOI: 10.1080/009841097160573
- 1997
  
  Profound effects of the weak environmental estrogen-like chemical bisphenol A on the growth of the mammary gland of noble rats. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 60:153-160.
  Full Text via DOI: 10.1016/S0960-0760(96)00130-6
- 1996
  
  Inhibition of stilbene estrogen-induced cell proliferation of renal epithelial cells through the modulation of insulin-like growth factor-I receptor expression. CANCER LETTERS. 105:51-59.
  Full Text via DOI: 10.1016/0304-3835(96)04263-2
- 1996
  
  Stilbene estrogen-mediated enhanced tyrosine phosphorylation of the nuclear protein p53 by nuclear matrix associated tyrosine kinase(s). INTERNATIONAL JOURNAL OF ONCOLOGY. 8:1011-1016.
- 1996
  
  Up-regulation of nuclear IGF-I receptor by short term exposure of stilbene estrogen, diethylstilbestrol. MOLECULAR AND CELLULAR ENDOCRINOLOGY. 118:1-8.
  Full Text via DOI: 10.1016/0303-7207(96)03751-3
- 1996
  
  Biochemical characterization of a mitomycin C-resistant human bladder cancer cell line. INTERNATIONAL JOURNAL OF CANCER. 65:852-857.
  Full Text via DOI: 10.1002/(SICI)1097-0215(19960315)65:6<852::AID-IJC24>3.0.CO;2-4
- 1996
  
  Exposure of environmental estrogenic compound nonylphenol to Noble rats alters cell-cycle kinetics in the mammary gland. ENDOCRINE. 4:115-122.
- 1996
  
  Mechanism of antiproliferative activity of luteolin against stilbene-estrogen stimulation of proliferation of hamster renal epithelial cells. INTERNATIONAL JOURNAL OF ONCOLOGY. 9:811-814.
  Full Text via DOI: 10.3892/ijo.9.4.811
- 1995
  
  Mutations in DNA polymerase β mRNA of stilbene estrogen-induced kidney tumors in Syrian hamster
- 1995
  
  Estrone-induced cell proliferation and differentiation in the mammary gland of the female noble rat. CARCINOGENESIS. 16:1955-1961.
  Full Text via DOI: 10.1093/carcin/16.8.1955
- 1995
  
  Perturbation of cell cycle kinetics in the mammary gland by stilbene estrogen, diethylstilbestrol (DES). CANCER LETTERS. 94:55-63.
  Full Text via DOI: 10.1016/0304-3835(95)03824-G
- 1995
  
  Activation of phosphorylation of plasma membrane insulin-like growth factor-i receptors in the kidney of syrian hamsters by diethylstilbestrol. CARCINOGENESIS. 16:1339-1344.
  Full Text via DOI: 10.1093/carcin/16.6.1339
- 1995
  
  Organ-specific inhibition of types I,II and III transcriptional activity in hamsters exposed to stilbene estrogen. CARCINOGENESIS. 16:1017-1021.
  Full Text via DOI: 10.1093/carcin/16.5.1017
- 1995
  
  In vivo binding of diethylstilbestrol to nuclear proteins of kidneys of Syrian hamsters. CANCER LETTERS. 90:215-224.
  Full Text via DOI: 10.1016/0304-3835(95)03706-3
- 1995
  
  Phosphorylation of Tyrosine Residues of RNA Polymerase II and Other Nuclear Proteins by Active Chromatin Tyrosin Kinase(s). BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 209:356-364.
  Full Text via DOI: 10.1006/bbrc.1995.1511
- 1995
  
  Mitochondrial enzyme-catalyzed oxidation and reduction reactions of stilbene estrogen. CARCINOGENESIS. 16:891-895.
  Full Text via DOI: 10.1093/carcin/16.4.891
- 1995
  
  Decreased cyclic inositol phosphohydrolase activity in hamster renal tumors and human renal cell carcinomas
  Full Text via DOI: 10.1006/bmme.1995.1064
- 1995
  
  Histone nuclear proteins are irreversibly modified by reactive metabolites of diethylstilbestrol
  Full Text via DOI: 10.1080/15287399509531973
- 1995
  
  In vitro conversion of environmental estrogenic chemical bisphenol A to DNA binding metabolite(s). BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 210:424-433.
  Full Text via DOI: 10.1006/bbrc.1995.1678
- 1995
  
  In vivo DNA adduct formation by bisphenol A. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 26:60-66.
  Full Text via DOI: 10.1002/em.2850260109
- 1995
  
  The antiproliferative effect of luteolin against diethylstilbestrol-induced cell proliferation in the mammary gland of rat. INTERNATIONAL JOURNAL OF ONCOLOGY. 7:1361-1366.
  Full Text via DOI: 10.3892/ijo.7.6.1361
- 1994
  
  Curcumin inhibits TPA induced expression of c-fos, c-jun and c-myc proto-oncogenes messenger RNAs in mouse skin. CANCER LETTERS. 87:85-89.
  Full Text via DOI: 10.1016/0304-3835(94)90413-8
- 1994
  
  Sex hormone-induced nuclear DNA damage and lipid peroxidation in the dorsolaterel prostates of Noble rats. CANCER LETTERS. 84:155-162.
  Full Text via DOI: 10.1016/0304-3835(94)90370-0
- 1994
  
  Catalysis of the oxidation and reduction reactions of steroid and stilbene estrogens by nuclear enzymes. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 315:310-316.
  Full Text via DOI: 10.1006/abbi.1994.1505
- 1993
  
  Modifications in the low mobility group nuclear proteins by reactive metabolites of diethylstilbestrol
- 1993
  
  In vivo genotoxicity of sodium ortho-phenylphenol: phenylbenzoquinone is one of the DNA-binding metabolite(s) of sodium ortho-phenylphenol
  Full Text via DOI: 10.1016/0027-5107(93)90196-M
- 1993
  
  Increased oxidative stress in the liver of mice treated with trichloroethylene
- 1993
  
  The carcinogenic activity of ethinyl estrogens is determined by both their hormonal characteristics and their conversion to catechol metabolites. ENDOCRINOLOGY. 132:577-583.
- 1992
  
  Examination of microsomal cytochrome P450-catalyzed in vitro activation of O-phenylphenol to DNA binding metabolite(s) by P-postlabeling technique. CARCINOGENESIS. 13:1593-1597.
  Full Text via DOI: 10.1093/carcin/13.9.1593
- 1992
  
  Catalysis of the oxidation of steroid and stilbene estrogens to estrogen quinone metabolites by the β-naphthoflavone-inducible cytochrome P450 IA family. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 296:450-456.
  Full Text via DOI: 10.1016/0003-9861(92)90596-O
- 1992
  
  Enhanced expression of membrane phosphoproteins tyrosine phosphorylation in estrogen-induced kidney tumors. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 186:228-236.
  Full Text via DOI: 10.1016/S0006-291X(05)80797-1
- 1992
  
  Lack of effectiveness of antiestrogens RU 39,411 or keoxifene in the prevention of estrogen-induced tumors in Syrian hamsters. CANCER LETTERS. 64:23-29.
  Full Text via DOI: 10.1016/0304-3835(92)90017-P
- 1992
  
  Elevation of protooncogene messenger RNAs in estrogen-induced kidney tumors in the hamster. CARCINOGENESIS. 13:601-604.
  Full Text via DOI: 10.1093/carcin/13.4.601
- 1992
  
  Target organ-specific inactivation of drug metabolizing enzymes in kidney of hamsters treated with estradiol
  Full Text via DOI: 10.1007/BF02385003
- 1992
  
  Changes in protein and nonprotein thiol contents in bladder, kidney and liver of mice by the pesticide sodium-o-phenylphenol and their possible role in cellular toxicity
- 1992
  
  Elevated 4-hydroxylation of estradiol by hamster kidney microsomes: A potential pathway of metabolic activation of estrogens. ENDOCRINOLOGY. 131:655-661.
- 1991
  
  Xanthine oxidase-catalyzed reduction of estrogen quinones to semiquinones and hydroquinones. BIOCHEMICAL PHARMACOLOGY. 42:1627-1631.
  Full Text via DOI: 10.1016/0006-2952(91)90433-6
- 1991
  
  Elevated 8-Hydroxydeoxyguanosine Levels in DNA of Diethylstilbestrol-treated Syrian Hamsters: Covalent DNA Damage by Free Radicals Generated by Redox Cycling of Diethylstilbestrol. CANCER RESEARCH. 51:3882-3885.
- 1991
  
  Determination of estradiol 2- and 4-hydroxylase activities by gas chromatography with electron-capture detection
  Full Text via DOI: 10.1016/0378-4347(91)80137-2
- 1991
  
  Cytochrome b5-mediated redox cycling of estrogen. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 285:331-338.
  Full Text via DOI: 10.1016/0003-9861(91)90368-S
- 1990
  
  Cytochrome P-450 catalyzed redox cycling of orthophenylphenol
- 1990
  
  Inhibition of estrogen-induced kidney carcinogenesis in syrian hamsters by modulators of estrogen metabolism. CARCINOGENESIS. 11:567-570.
  Full Text via DOI: 10.1093/carcin/11.4.567
- 1990
  
  The O⁶-methylation of 4-hydroxyestradiol is inhibited by 2-hydroxyestradiol: Implications for estrogen-induced carcinogenesis. CARCINOGENESIS. 11:459-462.
  Full Text via DOI: 10.1093/carcin/11.3.459
- 1990
  
  Covalent binding of phenytoin to protein and modulation of phenytoin metabolism by thiols in A/J mouse liver microsomes. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 252:895-900.
- 1990
  
  Cytochrome b5 mediated redox cycling of estrogens. FREE RADICAL BIOLOGY AND MEDICINE. 9:33.
  Full Text via DOI: 10.1016/0891-5849(90)90286-r
- 1990
  
  Effect of chronic estrogen treatment of syrian hamsters on microsomal enzymes mediating formation of catecholestrogens and their redox cycling: Implications for carcinogenesis
  Full Text via DOI: 10.1016/0022-4731(90)90198-2
- 1989
  
  Mechanism of inhibition of estrogen-induced renal carcinogenesis in male syrian hamsters by vitamin C. CARCINOGENESIS. 10:1983-1988.
  Full Text via DOI: 10.1093/carcin/10.11.1983
- 1989
  
  Metabolic oxidation of diethylstilbestrol to diethylstilbestrol-4', 4"-quinone in syrian hamsters. CARCINOGENESIS. 10:1241-1245.
  Full Text via DOI: 10.1093/carcin/10.7.1241
- 1989
  
  Changes in Activities of Free Radical Detoxifying Enzymes in Kidneys of Male Syrian Hamsters Treated with Estradiol. CANCER RESEARCH. 49:1475-1480.
- 1989
  
  Comparison of assays for catechol estrogen synthase activity: Product isolation vs radioenzymatic catechol-O-methyltransferase-coupled procedures
  Full Text via DOI: 10.1016/0022-4731(89)90300-2
- 1989
  
  Isocratic separation of phenytoin metabolites by high-performance liquid chromatography from human and animal microsomes and urine
  Full Text via DOI: 10.1097/00007691-198901000-00012
- 1988
  
  Effects of a cysteine precursor, L-2-oxothiazolidine-carboxylate, nutritional status, and sex on tissue glutathione and hepatic gsh-utilizing enzymes of CD-1 mice
- 1988
  
  Age-related change in the multiple unit activity of the rat brain parietal cortex and the effect of centrophenoxine. EXPERIMENTAL GERONTOLOGY. 23:161-174.
  Full Text via DOI: 10.1016/0531-5565(88)90003-4
- 1988
  
  Characterization of drug metabolism enzymes in estrogen-induced kidney tumors in male syrian hamsters. CANCER RESEARCH. 48:5726-5729.
- 1988
  
  Phenytoin metabolic activation: Role of cytochrome P-450, glutathione, age, and sex in rats and mice
- 1988
  
  Temporary decrease in renal quinone reductase activity induced by chronic administration of estradiol to male Syrian hamsters. Increased superoxide formation by redox cycling of estrogen. JOURNAL OF BIOLOGICAL CHEMISTRY. 263:3646-3651.
- 1987
  
  SHUNTING OF PHENYTOIN IN VITRO METABOLIC ACTIVATION BY GLUTATHIONE TO LESS REACTIVE METABOLITES: ANIMAL AND HUMAN FETAL TISSUE. PEDIATRIC RESEARCH. 21:242-242.
  Full Text via DOI: 10.1203/00006450-198704010-00447
- 1987
  
  Seizure induced changes in sister-chromatid exchange (SCE) frequency in epileptic patients
- 1984
  
  Changes in the activity of γ-amino butyric acid transaminase and succinic semialdehyde dehydrogenase in the cobalt and iron experimental epileptogenic focii in the rat brain
- 1984
  
  Effects of Chlorpromazine on the Activities of Antioxidant Enzymes and Lipid Peroxidation in the Various Regions of Aging Rat Brain. JOURNAL OF NEUROCHEMISTRY. 42:628-633.
  Full Text via DOI: 10.1111/j.1471-4159.1984.tb02728.x
- 1983
  
  Age-related changes in glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase in the subcellular fractions from the rat brain and the effect of dimethylaminoethanol
- 1983
  
  Effect of centrophenoxine on the antioxidative enzymes in various regions of the aging rat brain. EXPERIMENTAL GERONTOLOGY. 18:185-197.
  Full Text via DOI: 10.1016/0531-5565(83)90031-1
- Better Mechanistic Understanding of Big Data Through Order Search Using Causal Bayesian Networks
Book
- 2014
  
  Environmental Factors, Genes, and the Development of Human Cancers
- 2010
  
  Environmental factors, genes, and the development of human cancers
  Full Text via DOI: 10.1007/978-1-4419-6752-7
- 2010
  
  Environmental Factors, Genes, and the Development of Human Cancers
- 2010
  
  Environmental Factors, Genes, and the Development of Human Cancers Introduction
  Full Text via DOI: 10.1007/978-1-4419-6752-7_1 Web of Science: 000282535900001
Book Chapter
- 2022
  
  Environmental DNA insights in search of novel genes/taxa for production of biofuels and biomaterials. 111-135.
  Full Text via DOI: 10.1016/B978-0-12-823500-3.00015-7
- 2022
  
  Epigenome's environmental sensitivity and its impact on health. 451-478.
  Full Text via DOI: 10.1016/B978-0-12-823500-3.00009-1
- 2019
  
  Malformations of cortical development and epilepsy in children. 211-218.
  Full Text via DOI: 10.1016/B978-0-12-409548-9.11744-0
- 2016
  
  Integrated Bioinformatics, Biostatistics, and Molecular Epidemiologic Approaches to Study How the Environment and Genes Work Together to Influence the Development of Complex Chronic Diseases. 151-191.
  Web of Science: 000468317900006
- 2011
  
  Environment, Genetic and Epigenetic Alterations and Pediatric Central Nervous System Tumors. 559-568.
  Full Text via DOI: 10.1016/B978-0-444-52272-6.00071-4
- 2011
  
  Malformations of Cortical Development and Epilepsy in Children. 595-602.
  Full Text via DOI: 10.1016/B978-0-444-52272-6.00073-8
- 2010
  
  Approaches to Identify Environmental and Epigenomic Components or Covariates of Cancer and Disease Susceptibility. 197-219.
  Full Text via DOI: 10.1007/978-1-4419-6752-7_8 Web of Science: 000282535900008
- 2010
  
  Gene-Environment Interaction and Susceptibility to Pediatric Brain Tumors. 223-252.
  Full Text via DOI: 10.1007/978-1-4419-6752-7_9 Web of Science: 000282535900009
- 2010
  
  Introduction. 3-9.
  Full Text via DOI: 10.1007/978-1-4419-6752-7_1
- 2005
  
  Estrogen-Induced Mutations and Its Role in the Development of Tumorigenesis. 475-479.
  Full Text via DOI: 10.1007/0-387-23761-5_51
- 1998
  
  Pro-Oxidant and Antioxidant Effects of Estrogens. 425-435.
  Full Text via DOI: 10.1385/0-89603-472-0:425
- 1996
  
  Antiproliferative Activity of Luteolin, a Naturally-Occurring Edible Plant Flavone, Against Estrone-Induced Cell Proliferation in the Mammary Gland of Noble Rats. 471-474.
  Full Text via DOI: 10.1007/978-1-4612-2332-0_69
- 1996
  
  Increased Nuclear IGF-1 Receptor Level, Coupled with Attenuation in DNA Repair, Plays an Important Role in Estrogen-Induced Carcinogenesis. 463-466.
  Full Text via DOI: 10.1007/978-1-4612-2332-0_67
Conference
- 2020
  
  Aberrant transcription factor activity of NRF1, NFE2L2, E2F1, RFX1, and MEF2 associated with severity of astrocytoma. CANCER RESEARCH.
  Full Text via DOI: 10.1158/1538-7445.AM2020-4391 Web of Science: 000590059301273
- 2019
  
  Abstract 2441: Association between NRF1 regulatory gene networks and cancer and aging. 2441-2441.
  Full Text via DOI: 10.1158/1538-7445.sabcs18-2441
- 2019
  
  Association between NRF1 regulatory gene networks and cancer and aging. CANCER RESEARCH.
  Full Text via DOI: 10.1158/1538-7445.AM2019-2441 Web of Science: 000488279400400
- 2018
  
  Exosomal ID3 is pro-metastatic through guiding NRF1-induced breast cancer stem cells across the blood-brain-barrier. CANCER RESEARCH.
  Full Text via DOI: 10.1158/1538-7445.AM2018-1128 Web of Science: 000468818903101
- 2018
  
  Identifying the regulatory network structure of the genes involved in signaling pathways underlying ER-PR-HER2+breast cancer using Bayesian modeling of genome-wide NRF1 DNA motif sequence-enriched genes. CANCER RESEARCH.
  Full Text via DOI: 10.1158/1538-7445.AM2018-4274 Web of Science: 000468819502469
- 2018
  
  Role of NRF1 regulatory gene-networks in glioblastoma. CANCER RESEARCH.
  Full Text via DOI: 10.1158/1538-7445.AM2018-1127 Web of Science: 000468818903100
- 2017
  
  Abstract 1552: Integrative bioinformatics analyses of ChIP seq and RNA seq data reveals a complex regulatory landscape of NRF1 network involved in the pathogenesis of breast cancer. CANCER RESEARCH. 1552-1552.
  Full Text via DOI: 10.1158/1538-7445.am2017-1552
- 2016
  
  Abstract 3322: Estrogen and nuclear respiratory factor 1 act as joint mediators of redox modulation and stem cell aging that contribute in the pathogenesis of breast cancer. CANCER RESEARCH. 3322-3322.
  Full Text via DOI: 10.1158/1538-7445.am2016-3322
- 2015
  
  Overexpression of NRF1 leads to the generation of cancer stem-like cells and resistance to anoikis _ pathways to anchorage-independent growth during estrogen-induced malignant transformation. CANCER RESEARCH.
  Full Text via DOI: 10.1158/1538-7445.AM2015-803 Web of Science: 000371578501256
- 2015
  
  Phosphodeficient NRF1 mutant suppresses the susceptibility of the breast epithelial cells to develop tumors when exposed to estrogen - a major breast cancer risk factor. CANCER RESEARCH.
  Full Text via DOI: 10.1158/1538-7445.AM2015-4559 Web of Science: 000371597104187
- 2014
  
  Redox signaling to nuclear respiratory factor-1 proteins by reactive oxygen species contributes to the estrogen-induced breast tumor development. CANCER RESEARCH.
  Full Text via DOI: 10.1158/1538-7445.AM2014-3179 Web of Science: 000349910200183
- 2013
  
  Increased Risk of Childhood Brain Tumors among Children Whose Parents had Farm-Related Pesticide Exposures during Pregnancy. 2012-2017.
  Web of Science: 000357105902007
- 2012
  
  Novel 4-N-modified gemcitabine analogs. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
  Web of Science: 000324503201668
- 2011
  
  Estrogen-induced redox signaling via NRF-1 is involved in the development of breast cancer. CANCER RESEARCH.
  Full Text via DOI: 10.1158/1538-7445.AM2011-LB-12 Web of Science: 000209701305418
- 2011
  
  Identifying gene alterations required for the development of astrocytoma. 1037-1041.
  Web of Science: 000314989301008
- 2010
  
  Abstract 5050: Functional characterization of a newly identified growth regulatory gene SKCG-1 in human kidney cancer. CANCER RESEARCH. 5050-5050.
  Full Text via DOI: 10.1158/1538-7445.am10-5050
- 2010
  
  Abstract 604: Erucin treatment through induction of thioredoxin reductase may alter tamoxifen resistance in LCC2 cells. CANCER RESEARCH. 604-604.
  Full Text via DOI: 10.1158/1538-7445.am10-604
- 2009
  
  Redox Status Contributes to Tamoxifen-Resistant Growth of Breast Cancer.. CANCER RESEARCH. 810S-810S.
  Web of Science: 000272920702093
- 2009
  
  Hierarchical clustering method identifies adaptation of mitochondrial signaling to the treatment of mitochondrial blockers that regulates the expression of cell cycle genes. 708-714.
- 2009
  
  Meta-analysis of brain tumor microarray data using Oncomine identifies NRF1, Tfam and Myc co-expressed genes: Its implications in the development of childhood brain tumors. 720-726.
- 2009
  
  Oncomine meta-analysis of breast cancer microarray data identifies upregulation of NRF-1 expression in human breast carcinoma. 715-719.
- 2009
  
  NRF-1 signaling participates in the estrogen-mediated growth of breast cancer cells.. CANCER RESEARCH.
  Web of Science: 000209701803459
- 2009
  
  Hierarchical clustering method identifies adaptation of mitochondrial signaling to the treatment of mitochondrial blockers that regulates the expression of cell cycle genes.. 708-714.
  Web of Science: 000290045000109
- 2009
  
  Meta-analysis of brain tumor microarray data using Oncomine identifies NRF1, Tfam and Myc co-expressed genes: its implications in the development of childhood brain tumors. 720-726.
  Web of Science: 000290045000111
- 2009
  
  Oncomine meta-analysis of breast cancer microarray data identifies upregulation of NRF-1 expression in human breast carcinoma. 715-719.
  Web of Science: 000290045000110
- 2007
  
  Combined estrogen-progestogen contraceptives. 41-202.
- 2007
  
  Combined estrogen-progestogen menopausal therapy. 205-372.
- 2007
  
  General remarks. 33-35.
- 2007
  
  IARC monographs programme on the evaluation of carcinogenic risks to humans. 9-31.
- 2007
  
  Is in utero imprinting of the brain by pesticides involved in childhood brain cancer development?. EPIDEMIOLOGY. S169-S170.
  Web of Science: 000249018300556
- 2007
  
  4-OH-E2-induced oxidants through NRF-1 controls transcription of G1-S and G2-M phase cell cycle genes. FEBS JOURNAL. 179-179.
  Web of Science: 000253283800541
- 2006
  
  Estrogen-induced ROS signaling molecules and their role in brain cancer. CANCER RESEARCH.
  Web of Science: 000454608801202
- 1991
  
  Reactive potential of diethylstilbestrol reactive metabolites towards cellular nuclear proteins: Implications for estrogen-induced carcinogenesis. 809-812.
  Full Text via DOI: 10.1007/978-1-4684-5877-0_111
Note
- 2005
  
  Carcinogenicity of combined oestrogen-progestagen contraceptives and menopausal treatment. LANCET ONCOLOGY. 552-553.
  Full Text via DOI: 10.1016/S1470-2045(05)70273-4
Other Scholarly Work
- 2020
  
  Integrated chip-seq and RNA-seq data analysis coupled with bioinformatics approaches to investigate regulatory landscape of transcription modulators in breast cancer cells. 35-59.
  Full Text via DOI: 10.1007/978-1-0716-0223-2_3
- 2016
  
  Differences in the carcinogenic evaluation of glyphosate between the International Agency for Research on Cancer (IARC) and the European Food Safety Authority (EFSA). JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH. 741-745.
  Full Text via DOI: 10.1136/jech-2015-207005 Web of Science: 000380152600002
- 2016
  
  Origanum majorana organic extract induces senescence and autophagic cell death in breast cancer cells through influencing mitochondrial metabolism. CANCER RESEARCH.
  Full Text via DOI: 10.1158/1538-7445.AM2016-4061 Web of Science: 000389969803034
- 2016
  
  Association between serum concentrations of polychlorinated biphenyls (PCBs) and increased risk of breast cancer among US women. CANCER RESEARCH.
  Full Text via DOI: 10.1158/1538-7445.AM2016-3433 Web of Science: 000389940604187
- 2010
  
  Differential role of estrogen receptor positive NRF1(High) and NRF1(Low) cells in breast cancer development and progression. NEW BIOTECHNOLOGY. S25-S25.
  Full Text via DOI: 10.1016/j.nbt.2010.01.021 Web of Science: 000209825000061
- 2001
  
  Stilbene estrogen produces higher levels of mitochondrial DNA adducts than nuclear DNA adducts in the target organ of cancer (liver) of male Sprague Dawley rats.. ONCOLOGY REPORTS. 1035-1038.
  Full Text via DOI: 10.3892/or.8.5.1035
- 1993
  
  Insulin-like growth factor 1 receptors are increased in estrogen-induced kidney tumors.. CANCER RESEARCH. 2256-2259.
Preprint
- 2022
  
  Brain infiltration of breast cancer stem cells is facilitated by paracrine signaling by inhibitor of differentiation 3 to nuclear respiratory factor 1
  Full Text via DOI: 10.21203/rs.3.rs-1443283/v1
- 2018
  
  NRF1-Mediated Oncogenic Reprogramming Drives Estrogen-Induced Breast Carcinogenesis
  Full Text via DOI: 10.20944/preprints201809.0183.v1
Review
- 2020
  
  Environmental DNA and RNA as Records of Human Exposome, Including Biotic/Abiotic Exposures and Its Implications in the Assessment of the Role of Environment in Chronic Diseases
  Full Text via DOI: 10.3390/ijms21144879 Web of Science: 000557165000001
- 2018
  
  Interplay between NRF1, E2F4 and MYC transcription factors regulating common target genes contributes to cancer development and progression. 465-484.
  Full Text via DOI: 10.1007/s13402-018-0395-3 Web of Science: 000444812800001
- 2016
  
  Estrogenic Endocrine Disrupting Chemicals Influencing NRF1 Regulated Gene Networks in the Development of Complex Human Brain Diseases. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.
  Full Text via DOI: 10.3390/ijms17122086 Web of Science: 000392280500130
- 2013
  
  Thioredoxin-mediated redox regulation of resistance to endocrine therapy in breast cancer. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER. 60-79.
  Full Text via DOI: 10.1016/j.bbcan.2013.02.005 Web of Science: 000320475800006
- 2011
  
  Estrogen-induced reactive oxygen species-mediated signalings contribute to breast cancer. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER. 115-133.
  Full Text via DOI: 10.1016/j.bbcan.2010.10.005 Web of Science: 000287124400009
- 2007
  
  Estrogen-induced generation of reactive oxygen and nitrogen species, gene damage, and estrogen-dependent cancers. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS. 235-257.
  Full Text via DOI: 10.1080/15287390600974924 Web of Science: 000247875600001
- 2007
  
  Signature of mitochondria of steroidal hormones-dependent normal and cancer cells: Potential molecular targets for cancer therapy. FRONTIERS IN BIOSCIENCE. 154-173.
  Full Text via DOI: 10.2741/2056 Web of Science: 000243745000013
- 2005
  
  Estrogen, mitochondria, and growth of cancer and non-cancer cells
  Full Text via DOI: 10.1186/1477-3163-4-1
- 2004
  
  Genetics and bioenergetics of mitochondria influencing the etiology and pharmacology of steroidal hormones. 379-390.
  Full Text via DOI: 10.2174/1570160043377295
- 2004
  
  Estrogen-induced genetic alterations and their role in carcinogenicity. 245-257.
  Full Text via DOI: 10.2174/1389202043349471
- 2003
  
  Role of APC and DNA mismatch repair genes in the development of colorectal cancers
  Full Text via DOI: 10.1186/1476-4598-2-41
- 2000
  
  Estrogens as endogenous genotoxic agents--DNA adducts and mutations.. 75-93.
  Full Text via DOI: 10.1093/oxfordjournals.jncimonographs.a024247
- 1998
  
  Is exposure to environmental or industrial endocrine disrupting estrogen-like chemicals able to cause genomic instability?
  Full Text via DOI: 10.2741/A332
- 1990
  
  Free radical generation by redox cycling of estrogens. FREE RADICAL BIOLOGY AND MEDICINE. 415-423.
  Full Text via DOI: 10.1016/0891-5849(90)90108-U

principal investigator on

Estrogen-Induced Breast Cancer Pathogenesis awarded by U.S. Department of Veterans Affairs 2014 - 2018
Role of Estrogen-Induced Breast Cancer Pathogenesis awarded by U.S. Department of Veterans Affairs 2013 - 2015
Identification of the Mechanisms Underlying Antiestrogen Resistance: Breast Cancer Research Partnership between FIU - UM Braman Family Breast Cancer Institute. awarded by U.S. Department of Defense 2007 - 2012
Inhibition of Estrogen-Induced Growth of Breast Cancer by Targeting Mitochondria. awarded by Army Research Office 2007 - 2010

co-principal investigator on

Grant
- Alcohol Antiretrovirals in HIV Infection, Oxidative Stress and Liver Disease awarded by Alcohol Abuse and Alcoholism 2008 - 2014

investigator on

ID3, epigenetic reprogramming, and hyper-proilferative vascular remodeling awarded by National Heart, Lung, & Blood Institute 2019 - 2024

ORCID iD

https://orcid.org/0000-0001-6409-1341 (confirmed)

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