Rein, Kathleen

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Rein, Kathleen

Positions

Professor, Chemistry and Biochemistry , College of Arts, Sciences & Education

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selected scholarly works & creative activities

Article
- 2021
  
  The Marine Neurotoxin Brevetoxin (PbTx-2) Inhibits Karenia brevis and Mammalian Thioredoxin Reductases by Targeting Different Residues. JOURNAL OF NATURAL PRODUCTS. 84:2961-2970.
  Full Text via DOI: 10.1021/acs.jnatprod.1c00795 Web of Science: 000723680000021
- 2021
  
  Essential components of the xanthophyll cycle differ in high and low toxin Karenia brevis. HARMFUL ALGAE. 103.
  Full Text via DOI: 10.1016/j.hal.2021.102006 Web of Science: 000663075500004
- 2019
  
  Effectors of thioredoxin reductase: Brevetoxins and manumycin-A. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY. 217:76-86.
  Full Text via DOI: 10.1016/j.cbpc.2018.11.015 Web of Science: 000463848100009
- 2018
  
  Manumycin A Is a Potent Inhibitor of Mammalian Thioredoxin Reductase-1 (TrxR-1). ACS MEDICINAL CHEMISTRY LETTERS. 9:318-322.
  Full Text via DOI: 10.1021/acsmedchemlett.7b00489 Web of Science: 000430256200004
- 2018
  
  Brevetoxin (PbTx-2) influences the redox status and NPQ of Karenia brevis by way of thioredoxin reductase. HARMFUL ALGAE. 71:29-39.
  Full Text via DOI: 10.1016/j.hal.2017.11.004 Web of Science: 000423890200004
- 2017
  
  Toxin composition of the 2016 Microcystis aeruginosa bloom in the St. Lucie Estuary, Florida. TOXICON. 138:169-172.
  Full Text via DOI: 10.1016/j.toxicon.2017.09.005 Web of Science: 000413388300023
- 2017
  
  Brevetoxin-2, is a unique inhibitor of the C-terminal redox center of mammalian thioredoxin reductase-1. TOXICOLOGY AND APPLIED PHARMACOLOGY. 329:58-66.
  Full Text via DOI: 10.1016/j.taap.2017.05.027 Web of Science: 000406735700007
- 2017
  
  Metabolism of okadaic acid by NADPH-dependent enzymes present in human or rat liver S9 fractions results in different toxic effects. TOXICOLOGY IN VITRO. 42:161-170.
  Full Text via DOI: 10.1016/j.tiv.2017.04.009 Web of Science: 000404304900020
- 2016
  
  Differences in metabolism of the marine biotoxin okadaic acid by human and rat cytochrome P450 monooxygenases. ARCHIVES OF TOXICOLOGY. 90:2025-2036.
  Full Text via DOI: 10.1007/s00204-015-1591-9 Web of Science: 000379254500019
- 2016
  
  Characterization of an epoxide hydrolase from the Florida red tide dinoflagellate, Karenia brevis. PHYTOCHEMISTRY. 122:11-21.
  Full Text via DOI: 10.1016/j.phytochem.2015.11.002 Web of Science: 000369460200001
- 2015
  
  Brevetoxin, the Dinoflagellate Neurotoxin, Localizes to Thylakoid Membranes and Interacts with the Light-Harvesting Complex II (LHCII) of Photosystem II. CHEMBIOCHEM. 16:1060-1067.
  Full Text via DOI: 10.1002/cbic.201402669 Web of Science: 000353502300008
- 2015
  
  Student Response to a Partial Inversion of an Organic Chemistry Course for Non-Chemistry Majors. JOURNAL OF CHEMICAL EDUCATION. 92:797-802.
  Full Text via DOI: 10.1021/ed500537b Web of Science: 000355057300006
- 2013
  
  SUBCELLULAR LOCALIZATION OF DINOFLAGELLATE POLYKETIDE SYNTHASES AND FATTY ACID SYNTHASE ACTIVITY. JOURNAL OF PHYCOLOGY. 49:1118-1127.
  Full Text via DOI: 10.1111/jpy.12120 Web of Science: 000328343400010
- 2013
  
  Diastereoselective synthesis of deprotectable isoxazolidines. TETRAHEDRON LETTERS. 54:1866-1868.
  Full Text via DOI: 10.1016/j.tetlet.2013.01.105 Web of Science: 000316095000022
- 2013
  
  Synthesis, receptor binding and activity of iso and azakainoids. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 23:1949-1952.
  Full Text via DOI: 10.1016/j.bmcl.2013.02.046 Web of Science: 000316642900006
- 2013
  
  The use of Mosher derivatives for the determination of the absolute configuration of substituted isoxazolidines. TETRAHEDRON-ASYMMETRY. 24:223-228.
  Full Text via DOI: 10.1016/j.tetasy.2013.01.016 Web of Science: 000316167800012
- 2012
  
  Biosynthesis of Athmu, a alpha,gamma-hydroxy-beta-amino acid of pahayokolides A-B. TETRAHEDRON LETTERS. 53:6758-6760.
  Full Text via DOI: 10.1016/j.tetlet.2012.09.119 Web of Science: 000311473500006
- 2012
  
  The structures of three metabolites of the algal hepatotoxin okadaic acid produced by oxidation with human cytochrome P450. BIOORGANIC & MEDICINAL CHEMISTRY. 20:3742-3745.
  Full Text via DOI: 10.1016/j.bmc.2012.04.046 Web of Science: 000304486500007
- 2012
  
  Microbial degradation of microcystin in Florida's freshwaters. BIODEGRADATION. 23:35-45.
  Full Text via DOI: 10.1007/s10532-011-9484-y Web of Science: 000300283900004
- 2012
  
  Gene expression profiling of human liver carcinoma (HepG2) cells exposed to the marine toxin okadaic acid. TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY. 94:1805-1821.
  Full Text via DOI: 10.1080/02772248.2012.730199 Web of Science: 000310311500016
- 2011
  
  Biosynthetic Origin of the 3-Amino-2,5,7,8-tetrahydroxy-10-methylundecanoic Acid Moiety and Absolute Configuration of Pahayokolides A and B. JOURNAL OF NATURAL PRODUCTS. 74:1535-1538.
  Full Text via DOI: 10.1021/np200362q Web of Science: 000291920600028
- 2010
  
  Human metabolites of brevetoxin PbTx-2: Identification and confirmation of structure. TOXICON. 56:648-651.
  Full Text via DOI: 10.1016/j.toxicon.2010.06.007 Web of Science: 000281001800021
- 2010
  
  ChemInform Abstract: Analysis of (α‐Hydroxybenzyl)tetrahydroisoquinoline Stereoisomers by Pirkle Column HPLC: Correlation of Absolute Configuration with Order of Elution.
  Full Text via DOI: 10.1002/chin.199131300
- 2010
  
  ChemInform Abstract: Single Electron Transfer in the Addition of Chiral Dipole‐Stabilized Organolithiums to Carbonyls. Stereochemistry of a Chiral Nucleophile as a Mechanistic Probe.
  Full Text via DOI: 10.1002/chin.199205066
- 2010
  
  ChemInform Abstract: Brevetoxin B: Chemical Modifications, Synaptosome Binding, Toxicity, and an Unexpected Conformational Effect.
  Full Text via DOI: 10.1002/chin.199439282
- 2010
  
  ChemInform Abstract: Conformational Analysis of the Sodium Channel Modulator, Brevetoxin A, Comparison with Brevetoxin B Conformations, and a Hypothesis About the Common Pharmacophore of the “Site 5” Toxins.
  Full Text via DOI: 10.1002/chin.199439281
- 2010
  
  UV and solar TiO2 photocatalysis of brevetoxins (PbTxs). TOXICON. 55:1008-1016.
  Full Text via DOI: 10.1016/j.toxicon.2009.11.014 Web of Science: 000276436400013
- 2010
  
  Identification of okadaic acid production in the marine dinoflagellate Prorocentrum rhathymum from Florida Bay. TOXICON. 55:653-657.
  Full Text via DOI: 10.1016/j.toxicon.2009.08.018 Web of Science: 000274579100062
- 2010
  
  The algal hepatoxoxin okadaic acid is a substrate for human cytochromes CYP3A4 and CYP3A5. TOXICON. 55:325-332.
  Full Text via DOI: 10.1016/j.toxicon.2009.08.007 Web of Science: 000274579100020
- 2010
  
  Biodegradation of polyether algal toxins-Isolation of potential marine bacteria. JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING. 45:1850-1857.
  Full Text via DOI: 10.1080/10934529.2010.520510 Web of Science: 000282970900001
- 2009
  
  Viable cell sorting of dinoflagellates by multiparametric flow cytometry. PHYCOLOGIA. 48:249-257.
  Full Text via DOI: 10.2216/08-51.1 Web of Science: 000268126800003
- 2009
  
  Multiple simultaneous detection of Harmful Algal Blooms (HABs) through a high throughput bead array technology, with potential use in phytoplankton community analysis. HARMFUL ALGAE. 8:196-211.
  Full Text via DOI: 10.1016/j.hal.2008.05.003 Web of Science: 000262803800002
- 2008
  
  Diverse bacterial PKS sequences derived from okadaic acid-producing dinoflagellates
  Full Text via DOI: 10.3390/md20080009 Web of Science: 000257202100006
- 2008
  
  Allelopathic activity among Cyanobacteria and microalgae isolated from Florida freshwater habitats. FEMS MICROBIOLOGY ECOLOGY. 64:55-64.
  Full Text via DOI: 10.1111/j.1574-6941.2008.00439.x Web of Science: 000253886700006
- 2007
  
  1‐3‐Dipolar Cycloadditions of Trimethylsilyldiazomethane Revisited: Steric Demand of the Dipolarophile and the Influence on Product Distribution.
  Full Text via DOI: 10.1002/chin.200721105
- 2007
  
  Structures of pahayokolides A and B, cyclic peptides from a Lyngbya sp.. JOURNAL OF NATURAL PRODUCTS. 70:730-735.
  Full Text via DOI: 10.1021/np060389p Web of Science: 000246764300002
- 2007
  
  1,3-dipolar cycloadditions of trimethylsilyldiazomethane revisited: Steric demand of the dipolarophile and the influence on product distribution. JOURNAL OF ORGANIC CHEMISTRY. 72:650-653.
  Full Text via DOI: 10.1021/jo061838t Web of Science: 000243416300046
- 2006
  
  Ultrasonically induced degradation of microcystin-LR and -RR: Identification of products, effect of pH, formation and destruction of peroxides. ENVIRONMENTAL SCIENCE & TECHNOLOGY. 40:3941-3946.
  Full Text via DOI: 10.1021/es0521730 Web of Science: 000238217200045
- 2005
  
  Ultrasonically induced degradation and detoxification of microcystin-LR (cyanobacterial toxin). ENVIRONMENTAL SCIENCE & TECHNOLOGY. 39:6300-6305.
  Full Text via DOI: 10.1021/es048350z Web of Science: 000231203100056
- 2005
  
  Localization of polyketide synthase encoding genes to the toxic dinoflagellate Karenia brevis. PHYTOCHEMISTRY. 66:1767-1780.
  Full Text via DOI: 10.1016/j.phytochem.2005.06.010 Web of Science: 000231410800003
- 2005
  
  The toxicity of microcystin LR in mice following 7 days of inhalation exposure. TOXICON. 45:691-698.
  Full Text via DOI: 10.1016/j.toxicon.2005.01.004 Web of Science: 000228686500002
- 2005
  
  Low-mode docking search in iGluR homology models implicates three residues in the control of ligand selectivity. JOURNAL OF MOLECULAR RECOGNITION. 18:183-189.
  Full Text via DOI: 10.1002/jmr.713 Web of Science: 000227704400007
- 2004
  
  Pharmacology and toxicology of pahayokolide A, a bioactive metabolite from a freshwater species of Lyngbya isolated from the Florida Everglades. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY. 139:231-238.
  Full Text via DOI: 10.1016/j.cca.2004.11.005 Web of Science: 000227120600008
- 2004
  
  Aza Analogues of Kainoids by Dipolar Cycloaddition.
  Full Text via DOI: 10.1002/chin.200437194
- 2004
  
  Aza analogs of kainoids by dipolar cycloaddition. TETRAHEDRON LETTERS. 45:4703-4705.
  Full Text via DOI: 10.1016/j.tetlet.2004.04.097 Web of Science: 000221801100025
- 2003
  
  The structural basis for kainoid selectivity at AMPA receptors revealed by low-mode docking calculations. BIOORGANIC & MEDICINAL CHEMISTRY. 11:551-559.
  Full Text via DOI: 10.1016/S0968-0896(02)00448-0 Web of Science: 000180693900009
- 2003
  
  Polyketide synthase genes from marine dinoflagellates. MARINE BIOTECHNOLOGY. 5:1-12.
  Full Text via DOI: 10.1007/s10126-002-0077-y Web of Science: 000181333200001
- 2002
  
  Are Pfiesteria species toxicogenic? Evidence against production of ichthyotoxins by Pfiesteria shumwayae. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 99:10970-10975.
  Full Text via DOI: 10.1073/pnas.172221699 Web of Science: 000177606900007
- 2000
  
  Brevetoxin derivatives that inhibit toxin activity. CHEMISTRY & BIOLOGY. 7:385-393.
  Full Text via DOI: 10.1016/S1074-5521(00)00119-8 Web of Science: 000087683100004
- 1998
  
  UV-visible and inelastic electron tunneling spectroscopies of brevetoxins. APPLIED SPECTROSCOPY. 52:523-527.
  Full Text via DOI: 10.1366/0003702981944067 Web of Science: 000073512700008
- 1998
  
  Brevetoxin-3 (PbTx-3) and its derivatives modulate single tetrodotoxin-sensitive sodium channels in rat sensory neurons. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 284:516-525.
  Web of Science: 000071929100012
- 1997
  
  Brevetoxin-6 (PbTx-6), a nonaromatic marine neurotoxin, is a ligand of the aryl hydrocarbon receptor. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 343:149-156.
  Full Text via DOI: 10.1006/abbi.1997.0149 Web of Science: A1997XL43100001
- 1996
  
  Assessment of methods for the determination of ciguatoxins. TOXICON. 34:306.
  Full Text via DOI: 10.1016/0041-0101(96)80918-4
- 1995
  
  THE RELATIONSHIP OF BREVETOXIN LENGTH AND A-RING FUNCTIONALITY TO BINDING AND ACTIVITY IN NEURONAL SODIUM-CHANNELS. CHEMISTRY & BIOLOGY. 2:533-541.
  Full Text via DOI: 10.1016/1074-5521(95)90187-6 Web of Science: A1995RR27500006
- 1995
  
  BREVETOXIN-3 - TOTAL ASSIGNMENT OF THE H-1 AND C-13 NMR-SPECTRA AT THE SUBMICROMOLE LEVEL. TETRAHEDRON. 51:8409-8422.
  Full Text via DOI: 10.1016/0040-4020(95)00360-K Web of Science: A1995RL91100003
- 1995
  
  MODIFIED IMMUNOASSAYS FOR POLYETHER TOXINS - IMPLICATIONS OF BIOLOGICAL MATRICES, METABOLIC STATES, AND EPITOPE RECOGNITION
  Web of Science: A1995QN30400038
- 1995
  
  RADIOIMMUNOASSAY FOR PBTX-2-TYPE BREVETOXINS - EPITOPE SPECIFICITY OF 2 ANTI-PBTX SERA
  Web of Science: A1995QN30400044
- 1994
  
  BREVETOXIN-PBTX-2 IMMUNOLOGY - DIFFERENTIAL EPITOPE RECOGNITION BY ANTIBODIES FROM 2 GOATS. TOXICON. 32:883-890.
  Full Text via DOI: 10.1016/0041-0101(94)90367-0 Web of Science: A1994PA94100004
- 1994
  
  BREVETOXIN-B - CHEMICAL MODIFICATIONS, SYNAPTOSOME BINDING, TOXICITY, AND AN UNEXPECTED CONFORMATIONAL EFFECT. JOURNAL OF ORGANIC CHEMISTRY. 59:2107-2113.
  Full Text via DOI: 10.1021/jo00087a028 Web of Science: A1994NJ13700028
- 1994
  
  CONFORMATIONAL-ANALYSIS OF THE SODIUM-CHANNEL MODULATOR, BREVETOXIN-A, COMPARISON WITH BREVETOXIN-B CONFORMATIONS, AND A HYPOTHESIS ABOUT THE COMMON PHARMACOPHORE OF THE SITE-5 TOXINS. JOURNAL OF ORGANIC CHEMISTRY. 59:2101-2106.
  Full Text via DOI: 10.1021/jo00087a027 Web of Science: A1994NJ13700027
- 1994
  
  Is the A‐ring lactone of brevetoxin PbTX‐3 required for sodium channel orphan receptor binding and activity?
  Full Text via DOI: 10.1002/nt.2620020410
- 1991
  
  SINGLE ELECTRON-TRANSFER IN THE ADDITION OF CHIRAL DIPOLE-STABILIZED ORGANOLITHIUMS TO CARBONYLS - STEREOCHEMISTRY OF A CHIRAL NUCLEOPHILE AS A MECHANISTIC PROBE. TETRAHEDRON LETTERS. 32:1941-1944.
  Full Text via DOI: 10.1016/0040-4039(91)85007-R Web of Science: A1991FG50000006
- 1991
  
  SYNTHESIS OF THE PHTHALIDE ISOQUINOLINE ALKALOIDS (-)-EGENINE, (-)-CORYTENSINE, AND (-)-BICUCULLINE BY ASYMMETRIC CARBONYL ADDITION OF CHIRAL DIPOLE-STABILIZED ORGANOMETALLICS. JOURNAL OF ORGANIC CHEMISTRY. 56:1564-1569.
  Full Text via DOI: 10.1021/jo00004a041 Web of Science: A1991EY47600041
- 1990
  
  SYNTHESIS OF (-)-EGENINE (DECUMBENSINE) BY ASYMMETRIC CARBONYL ADDITION. TETRAHEDRON LETTERS. 31:3711-3714.
  Full Text via DOI: 10.1016/S0040-4039(00)97451-3 Web of Science: A1990DL87800014
- 1989
  
  ChemInform Abstract: Acyclic Stereoselection in the Alkylation of Chiral Dipole‐Stabilized Organolithiums: A Self‐Immolative Chirality Transfer Process for the Synthesis of Primary Amines.
  Full Text via DOI: 10.1002/chin.198948124
- 1989
  
  ChemInform Abstract: Chiral Dipole‐Stabilized Anions: Experimental and Theory in Benzylic and Allylic Systems. Stereoselective Deprotonations, Pyramidal Inversions, and Stereoselective Alkylations of Lithiated (Tetrahydroisoquinolyl)oxazolines.
  Full Text via DOI: 10.1002/chin.198926065
- 1989
  
  CHIRAL DIPOLE-STABILIZED ANIONS - EXPERIMENT AND THEORY IN BENZYLIC AND ALLYLIC SYSTEMS - STEREOSELECTIVE DEPROTONATIONS, PYRAMIDAL INVERSIONS, AND STEREOSELECTIVE ALKYLATIONS OF LITHIATED (TETRAHYDROISOQUINOLYL)OXAZOLINES. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 111:2211-2217.
  Full Text via DOI: 10.1021/ja00188a040 Web of Science: A1989T780200040
Book Chapter
- 1998
  
  Marine Toxins: How They are Studied and What They Can Tell Us. 487-514.
  Full Text via DOI: 10.1007/978-94-011-4928-0_26
- 1991
  
  1.2 Alkylations of Nitrogen-stabilized Carbanions. 65-83.
  Full Text via DOI: 10.1016/b978-0-08-052349-1.00059-7
- 1991
  
  2.1 Nitrogen Stabilization. 459-485.
  Full Text via DOI: 10.1016/b978-0-08-052349-1.00014-7
Conference
- 2019
  
  Brevetoxin is an effector of mammalian thioredoxin reductase (TrxR). ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
  Web of Science: 000478861200713
- 2013
  
  Black band disease (BBD): Pigment characterization and reactive oxygen species (ROS) production and evolution assay development. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
  Web of Science: 000323851302112
- 2008
  
  Ultrasonically-induced degradation of microcystin LR and RR: Identification of byproducts and effect of environmental factors. 305-306.
  Web of Science: 000254893200028
- 2007
  
  1, 3-Dipolar cycloadditons of TMS diazomethane revisited. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
  Web of Science: 000207722808137
- 2005
  
  Mechanistic study of ultrasonic irradiation of microcystin-LR. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U834-U834.
  Web of Science: 000228177706051
- 2004
  
  Photodegradation and oxidation of microcystin.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U625-U625.
  Web of Science: 000223655602114
- 2004
  
  Syntheses of aza analogs of kainoids. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U138-U138.
  Web of Science: 000223655700720
- 2004
  
  Ultrasound treatment of cyantoxin microcystin-LR. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U1058-U1058.
  Web of Science: 000223655603620
- 2002
  
  Is Pfiesteria toxigenic? Chemical and molecular evidence against polyketide and non-ribosomal peptide toxin production by Pfiesteria shumwayae.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. B232-B232.
  Web of Science: 000176296801295
- 2002
  
  Low-mode conformational search of kainic acid in homology models of non-NMDA receptors.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U223-U223.
  Web of Science: 000176296701160
- 2002
  
  Low-mode conformational search of kanoids in the AMPA receptor: The basis of kanoid selectivity.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U223-U223.
  Web of Science: 000176296701161
- 2001
  
  Synthesis of kainic acid analogs.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U151-U151.
  Web of Science: 000168824701283
- 1995
  
  MECHANISM OF INDUCTION OF CYTOCHROME P4501A BY BREVETOXIN (PBTX), A POLYETHER MARINE NEUROTOXIN. FASEB JOURNAL. A714-A714.
  Web of Science: A1995QM40600517
- 1994
  
  BREVETOXIN-3 (PBTX-3) AND ITS DERIVATIVES MODULATE SINGLE SODIUM-CHANNELS IN RAT SENSORY NEURONS. BIOPHYSICAL JOURNAL. A323-A323.
  Web of Science: A1994MU46201877
- 1992
  
  COMPUTATIONAL MODELING OF THE POLYETHER LADDER TOXINS BREVETOXIN AND CIGUATOXIN. 103-114.
  Web of Science: A1992BX60R00010
Letter
- 1989
  
  ACYCLIC STEREOSELECTION IN THE ALKYLATION OF CHIRAL DIPOLE-STABILIZED ORGANOLITHIUMS - A SELF-IMMOLATIVE CHIRALITY TRANSFER PROCESS FOR THE SYNTHESIS OF PRIMARY AMINES. JOURNAL OF ORGANIC CHEMISTRY. 3002-3004.
  Full Text via DOI: 10.1021/jo00274a004 Web of Science: A1989AC85000004
Note
- 1992
  
  BINDING OF BREVETOXINS AND CIGUATOXIN TO THE VOLTAGE-SENSITIVE SODIUM-CHANNEL AND CONFORMATIONAL-ANALYSIS OF BREVETOXIN-B. TOXICON. 780-785.
  Full Text via DOI: 10.1016/0041-0101(92)90014-V Web of Science: A1992JD02000014
- 1991
  
  ANALYSIS OF (ALPHA-HYDROXYBENZYL)TETRAHYDROISOQUINOLINE STEREOISOMERS BY PIRKLE COLUMN HPLC - CORRELATION OF ABSOLUTE-CONFIGURATION WITH ORDER OF ELUTION. JOURNAL OF ORGANIC CHEMISTRY. 839-841.
  Full Text via DOI: 10.1021/jo00002a062 Web of Science: A1991EU10800062
Other Scholarly Work
- 2014
  
  In vivo demonstration of okadaic acid internalization in glutamatergic spinal motor neurons. FASEB JOURNAL.
  Web of Science: 000346651000350
Review
- 2010
  
  New Peptides Isolated from Lyngbya Species: A Review. 1817-1837.
  Full Text via DOI: 10.3390/md8061817 Web of Science: 000280347000008
- 2006
  
  The biosynthesis of polyketide metabolites by dinoflagellates. 93-125.
  Full Text via DOI: 10.1016/S0065-2164(06)59004-5 Web of Science: 000239588000004
- 1999
  
  Polyketides from dinoflagellates: origins, pharmacology and biosynthesis. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY. 117-131.
  Full Text via DOI: 10.1016/S0305-0491(99)00107-8 Web of Science: 000082764400001
- 1992
  
  Methods for detecting brevetoxins in seawater, in biological matrices, and on excitable membranes.. 516-518.

chaired theses and dissertations

Chen, Wei, Characterization of Interaction Between Brevetoxin and Its Native Receptor and Identification of the Role of Brevetoxin in Karenia brevis 2016
sun, pengfei, Characterization of an Epoxide Hydrolase from the Florida Red Tide Dinoflagellate, Karenia brevis 2015
Cassell, Ryan T, Synthesis of a PbTx-2 photoaffinity and fluorescent probe and an alternative synthetic route to photoaffinity probes 2014
Wang, Wentian, Asymmetric Syntheses of Analogs of Kainic Acid 2012
Liu, Li, Absolute Configuration and Biosynthesis of Pahayokolide A from Lyngbya sp. Strain 15-2 of the Florida Everglades 2009
Di, Mingping, Syntheses of aza analogs of kainoids 2006

principal investigator on

A Mechanism Based Intervention for Brevetoxin Induced Oxidative Stress awarded by National Oceanic and Atmospheric Admin 2018 - 2022
Red Tide Initiative awarded by nTEC Solutions LLC 2021 - 2022
Bridge Funding - Chemistry Lab awarded by FIU Office of Research and Economic Deve 2012 - 2014
Advanced Research Cooperation in Environmental Health (ARCH)/Admin Supplement awarded by Environmental Health Sciences 2011 - 2012
Advanced Research Cooperation in Environmental Health Research awarded by Environmental Health Sciences 2010 - 2012
COHH Toxic Algae Project awarded by National Science Foundation 2009 - 2011
A Proposal for the Synthesis of Putative Salmeterol Degradation Product awarded by Teva Pharmaceuticals 2009 - 2010
Advanced Research Cooperation in Environmental Health Research awarded by Environmental Health Sciences 2009 - 2010
Toxic Algae. awarded by National Science Foundation 2004 - 2010
Oceans and Human Health Toxic Algae Facility Core. awarded by Environmental Health Sciences 2008 - 2009
Advance Research Cooperation in Environmental Health (ARCH). awarded by Environmental Health Sciences 2008 - 2009
Advanced Research Cooperation in Environmental Health (ARCH). awarded by Environmental Health Sciences 2007 - 2009
Synthesis of Impurity D from Salmeterol. awarded by Teva Pharmaceuticals 2008 - 2009

co-principal investigator on

Grant
- Biscayne Bay PhycoNet: a monitoring network and database capturing the biological and biochemical diversity of phytoplankton for the rapid detection of toxic bloom-forming taxa awarded by National Oceanic and Atmospheric Admin 2022 - 2025
- Collaborative for Instiutionalizing Scientific Learning at FIU awarded by Howard Hughes Medical Institute 2014 - 2021
- Advanced Research Cooperation in Environmental Health Research awarded by Environmental Health Sciences 2010 - 2012
- Advanced Research Cooperation in Environmental Health Research awarded by Environmental Health Sciences 2009 - 2010

ORCID iD

https://orcid.org/0000-0001-9268-1584 (confirmed)

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publication subject areas

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