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Ng, Hooi Hooi
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Scholarly & Creative Works
Research
Identifiers
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Scholarly & Creative Works
Patents issued
Materials and Methods for the Treatment of Vascular Calcification
Patent
selected scholarly works & creative activities
Article
2022
The Time-Dependent Role of Bisphosphonates on Atherosclerotic Plaque Calcification
Full Text via DOI:
10.3390/jcdd9060168
Web of Science:
000816404400001
2022
S2 Heart Sound Detects Aortic Valve Calcification Independent of Hemodynamic Changes in Mice
.
FRONTIERS IN CARDIOVASCULAR MEDICINE
. 9.
Full Text via DOI:
10.3389/fcvm.2022.809301
Web of Science:
000807820700001
2021
Abstract 14001: Using the S2 Sound as an Early Marker of Aortic Valve Calcification
.
CIRCULATION
. 144:a14001-a14001.
Full Text via DOI:
10.1161/circ.144.suppl_1.14001
2021
Anti-apoptotic and Matrix Remodeling Actions of a Small Molecule Agonist of the Human Relaxin Receptor, ML290 in Mice With Unilateral Ureteral Obstruction
.
FRONTIERS IN PHYSIOLOGY
. 12.
Full Text via DOI:
10.3389/fphys.2021.650769
Web of Science:
000674951600001
2021
Tracking Acoustic and Electrophysiological Changes Associated with CKD-induced Cardiac and Valvular Remodeling in a Mouse Model
Full Text via DOI:
10.1080/24748706.2021.1901527
2020
Abstract 17021: A Novel Human Relaxin Receptor Agonist, ML290, Attenuates Atherosclerosis- and Chronic Kidney Disease-Induced Vascular Calcification in Mice
.
CIRCULATION
. 142.
Full Text via DOI:
10.1161/circ.142.suppl_3.17021
2020
Annexin-A1 deficiency exacerbates pathological remodelling of the mesenteric vasculature in insulin-resistant, but not insulin-deficient, mice
.
BRITISH JOURNAL OF PHARMACOLOGY
. 177:1677-1691.
Full Text via DOI:
10.1111/bph.14927
Web of Science:
000512355800001
2020
Relaxin reduces endothelium-derived vasoconstriction in hypertension: Revealing new therapeutic insights
.
BRITISH JOURNAL OF PHARMACOLOGY
. 177:217-233.
Full Text via DOI:
10.1111/bph.14858
Web of Science:
000493438200001
2019
Therapeutic effects of a small molecule agonist of the relaxin receptor ML290 in liver fibrosis
.
FASEB JOURNAL
. 33:12435-12446.
Full Text via DOI:
10.1096/fj.201901046R
Web of Science:
000507461600065
2019
Relaxin and extracellular matrix remodeling: Mechanisms and signaling pathways
.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
. 487:59-65.
Full Text via DOI:
10.1016/j.mce.2019.01.015
Web of Science:
000463350300010
2019
Small molecule allosteric agonist of relaxin receptor ML290 demonstrates antifibrotic properties in liver fibrosis
Full Text via DOI:
10.1530/endoabs.63.gp223
2019
Targeting the relaxin/insulin-like family peptide receptor 1 and 2 with small molecule compounds
.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
. 487:40-44.
Full Text via DOI:
10.1016/j.mce.2018.12.013
Web of Science:
000463350300007
2019
SAT-035 Small Molecule Allosteric Agonist of Relaxin Receptor Ml290 Demonstrates Antifibrotic Properties in Liver Fibrosis
Full Text via DOI:
10.1210/js.2019-sat-035
2019
Recent developments in relaxin mimetics as therapeutics for cardiovascular diseases
Full Text via DOI:
10.1016/j.coph.2019.04.001
Web of Science:
000483006200007
2017
Endothelial dysfunction in the aorta of non-pregnant relaxin-deficient mice is not observed in pregnancy
.
PLACENTA
. 57:272.
Full Text via DOI:
10.1016/j.placenta.2017.07.158
2017
Chronic NaHS treatment decreases oxidative stress and improves endothelial function in diabetic mice
Full Text via DOI:
10.1177/1479164117692766
2017
Serelaxin treatment reduces oxidative stress and increases aldehyde dehydrogenase-2 to attenuate nitrate tolerance
Full Text via DOI:
10.3389/fphar.2017.00141
2017
1,4-Anhydro-4-seleno-D-talitol (SeTal) protects endothelial function in the mouse aorta by scavenging superoxide radicals under conditions of acute oxidative stress
.
BIOCHEMICAL PHARMACOLOGY
. 128:34-45.
Full Text via DOI:
10.1016/j.bcp.2016.12.019
2017
Serelaxin treatment reverses vascular dysfunction and left ventricular hypertrophy in a mouse model of Type 1 diabetes
Full Text via DOI:
10.1038/srep39604
2017
B7-33 replicates the vasoprotective functions of human relaxin-2 (serelaxin)
.
EUROPEAN JOURNAL OF PHARMACOLOGY
. 807:190-197.
Full Text via DOI:
10.1016/j.ejphar.2017.05.005
2016
Adverse vascular remodelling is more sensitive than endothelial dysfunction to hyperglycaemia in diabetic rat mesenteric arteries
.
PHARMACOLOGICAL RESEARCH
. 111:325-335.
Full Text via DOI:
10.1016/j.phrs.2016.06.025
2016
Serelaxin (recombinant human relaxin-2) prevents high glucose-induced endothelial dysfunction by ameliorating prostacyclin production in the mouse aorta
.
PHARMACOLOGICAL RESEARCH
. 107:220-228.
Full Text via DOI:
10.1016/j.phrs.2016.03.011
2016
Time-dependent activation of prostacyclin and nitric oxide pathways during continuous i.v. infusion of serelaxin (recombinant human H2 relaxin)
.
BRITISH JOURNAL OF PHARMACOLOGY
. 173:1005-1017.
Full Text via DOI:
10.1111/bph.13404
2015
Increased superoxide production and altered nitric oxide-mediated relaxation in the aorta of young but not old male relaxin-deficient mice
.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
. 309:H285-H296.
Full Text via DOI:
10.1152/ajpheart.00786.2014
2014
Hydrogen sulfide protects endothelial nitric oxide function under conditions of acute oxidative stress in vitro.
Full Text via DOI:
10.1007/s00210-013-0920-x
2013
OP15 Hydrogen sulfide protects endothelial function under conditions of oxidative stress
.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
. 31:s25.
Full Text via DOI:
10.1016/j.niox.2013.06.045
Book Chapter
2020
Calcifying Extracellular Vesicles: Biology, Characterization, and Mineral Formation
. 97-116.
Full Text via DOI:
10.1007/978-3-030-46725-8_5
Conference
2020
Therapeutic Effects of a Small Molecule Agonist of the Relaxin Receptor in Mice with Unilateral Ureteral Obstruction
.
FASEB JOURNAL
.
Full Text via DOI:
10.1096/fasebj.2020.34.s1.09260
Web of Science:
000546107900377
Other Scholarly Work
2021
A Biased Relaxin Receptor Agonist, ML290, Attenuates Atherosclerotic Calcification in Apolipoprotein E-deficient Mice
.
FASEB JOURNAL
.
Full Text via DOI:
10.1096/fasebj.2021.35.S1.02926
Web of Science:
000669893102336
2013
Hydrogen sulfide as a vasculoprotective factor.
. 9.
Full Text via DOI:
10.1186/2045-9912-3-9
Preprint
2022
Time-dependent Role of Bisphosphonates on Atherosclerotic Plaque Calcification
Full Text via DOI:
10.1101/2022.02.14.479950
2021
Epidermal Growth Factor Receptor Inhibition Prevents Caveolin-1-dependent Calcifying Extracellular Vesicle Biogenesis
Full Text via DOI:
10.1101/2021.11.08.467799
Review
2018
Relaxin as a Therapeutic Target for the Cardiovascular Complications of Diabetes
.
FRONTIERS IN PHARMACOLOGY
.
Full Text via DOI:
10.3389/fphar.2018.00501
Web of Science:
000432304100001
2017
Vascular actions of relaxin: nitric oxide and beyond
.
BRITISH JOURNAL OF PHARMACOLOGY
. 1002-1014.
Full Text via DOI:
10.1111/bph.13614
2016
Serelaxin: A Novel Therapeutic for Vascular Diseases
.
TRENDS IN PHARMACOLOGICAL SCIENCES
. 498-507.
Full Text via DOI:
10.1016/j.tips.2016.04.001
Research
principal investigator on
Small Molecule Agonist of the Human Relaxin Receptor for Treatment of Vascular Calcification
awarded by
FIU Foundation
2020 - 2021
Targeting relaxin receptor for the treatment of diabetes-induced cardiovascular calcification
awarded by
American Heart Association
2019 - 2020
subproject principal investigator on
Targeting the oxidative signaling pathway in vascular calcification
awarded by
Florida Heart Research Foundation Inc
2021 - 2023
Identifiers
ORCID iD
https://orcid.org/0000-0002-2370-0849
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publication subject areas
Cell Biology
Endocrinology & Metabolism
Pharmacology & Pharmacy
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