FIU Discovery

DRP1 induces neuroinflammation via transcriptional regulation of NF-ĸB..  NATURE COMMUNICATIONS.  17.

DRP1 induces neuroinflammation via transcriptional regulation of NF-ĸB..  bioRxiv. 

Imbalanced mitochondrial dynamics in human PD and α-synuclein mouse brains.  Neurobiology of Disease.  212.

Obesity increases genomic instability at DNA repeat-mediated endogenous mutation hotspots.  NATURE COMMUNICATIONS.  15.

DNA Base Damage Repair Crosstalks with Chromatin Structures to Contract Expanded GAA Repeats in Friedreich's Ataxia.  Biomolecules.  14.

A partial Drp1 knockout improves autophagy flux independent of mitochondrial function.  Molecular Neurodegeneration.  19.

Scanning Ion Conductance Microscopy Study Reveals the Disruption of the Integrity of the Human Cell Membrane Structure by Oxidative DNA Damage.  ACS APPLIED BIO MATERIALS.  4:1632-1639.

Natamycin reduces prostate cancer proliferation by inhibiting base-excision repair mechanism

R-loops promote trinucleotide repeat deletion through DNA base excision repair enzymatic activities.  JOURNAL OF BIOLOGICAL CHEMISTRY.  295:13902-13913.

Dynamic single-cell intracellular pH sensing using a SERS-active nanopipette.  ANALYST.  145:4852-4859.

N⁶-methyladenosine mediates arsenite-induced human keratinocyte transformation by suppressing p53 activation.  ENVIRONMENTAL POLLUTION.  259.

Androgen Receptor and Poly(ADP-ribose) Glycohydrolase Inhibition Increases Efficiency of Androgen Ablation in Prostate Cancer Cells.  SCIENTIFIC REPORTS.  10.

Inhibition of base excision repair by natamycin suppresses prostate cancer cell proliferation.  BIOCHIMIE.  168:241-250.

Oxidative DNA Damage Modulates DNA Methylation Pattern in Human Breast Cancer 1 (BRCA1) Gene via the Crosstalk between DNA Polymerase β and a de novo DNA Methyltransferase.  CELLS.  9.

Tyrosyl-DNA Phosphodiesterase 1 and Topoisomerase I Activities as Predictive Indicators for Glioblastoma Susceptibility to Genotoxic Agents.  CANCERS.  11.

Diastereomeric Recognition of 5′,8-cyclo-2′-Deoxyadenosine Lesions by Human Poly(ADP-ribose) Polymerase 1 in a Biomimetic Model.  CELLS.  8.

Methods to Study Trinucleotide Repeat Instability Induced by DNA Damage and Repair.  Methods in molecular biology (Clifton, N.J.).  1999:87-101.

The deoxyribose phosphate lyase of DNA polymerase β suppresses a processive DNA synthesis to prevent trinucleotide repeat instability.  NUCLEIC ACIDS RESEARCH.  46:8940-8952.

An oxidized abasic lesion inhibits base excision repair leading to DNA strand breaks in a trinucleotide repeat tract.  PLOS ONE.  13.

miR-155 mediates arsenic trioxide resistance by activating Nrf2 and suppressing apoptosis in lung cancer cells.  SCIENTIFIC REPORTS.  7.

Brevetoxin-2, is a unique inhibitor of the C-terminal redox center of mammalian thioredoxin reductase-1.  Toxicology and Applied Pharmacology.  329:58-66.

Protection of Nrf2 Against Arsenite-induced Oxidative Damage is Regulated by the Cyclic Guanosine Monophosphate-Protein Kinase G Signaling Pathway.  ENVIRONMENTAL TOXICOLOGY.  32:2004-2020.

Modulation of trinucleotide repeat instability by DNA polymerase β polymorphic variant R137Q.  PLOS ONE.  12.

Proliferating cell nuclear antigen prevents trinucleotide repeat expansions by promoting repeat deletion and hairpin removal.  DNA REPAIR.  48:17-29.

Crosstalk between MSH2-MSH3 and pol β promotes trinucleotide repeat expansion during base excision repair.  NATURE COMMUNICATIONS.  7.

AP endonuclease 1 prevents the extension of a T/G mismatch by DNA polymerase β to prevent mutations in CpGs during base excision repair.  DNA REPAIR.  43:89-97.

Bypass of a 5′,8-cyclopurine-2′-deoxynucleoside by DNA polymerase β during DNA replication and base excision repair leads to nucleotide misinsertions and DNA strand breaks.  DNA REPAIR.  33:24-34.

AP endonuclease 1 prevents trinucleotide repeat expansion via a novel mechanism during base excision repair.  NUCLEIC ACIDS RESEARCH.  43:5948-5960.

The role of NF-κB in PARP-inhibitor-mediated sensitization and detoxification of arsenic trioxide in hepatocellular carcinoma cells.  Journal of Toxicological Sciences.  40:349-363.

Resveratrol Protects Against Arsenic Trioxide-Induced Oxidative Damage Through Maintenance of Glutathione Homeostasis and Inhibition of Apoptotic Progression.  ENVIRONMENTAL AND MOLECULAR MUTAGENESIS.  56:333-346.

A 5′, 8-cyclo-2′-deoxypurine lesion induces trinucleotide repeat deletion via a unique lesion bypass by DNA polymerase β.  NUCLEIC ACIDS RESEARCH.  42:13749-13763.

Base Excision Repair of Chemotherapeutically-Induced Alkylated DNA Damage Predominantly Causes Contractions of Expanded GAA Repeats Associated with Friedreich's Ataxia.  PLOS ONE.  9.

Base excision repair of oxidative DNA damage coupled with removal of a CAG repeat hairpin attenuates trinucleotide repeat expansion.  NUCLEIC ACIDS RESEARCH.  42:3675-3691.

Involvement of DNA polymerase beta overexpression in the malignant transformation induced by benzo[a]pyrene.  Toxicology.  309:73-80.

Instability of CTG Repeats Is Governed by the Position of a DNA Base Lesion through Base Excision Repair.  PLOS ONE.  8.

Deregulated expression of DNA polymerase beta is involved in the progression of genomic instability.  ENVIRONMENTAL AND MOLECULAR MUTAGENESIS.  53:325-333.

Antioxidant activities of Ganoderma lucidum polysaccharides and their role on DNA damage in mice induced by cobalt-60 gamma-irradiation.  Food and Chemical Toxicology.  50:303-309.

Role of DNA Polymerase Beta in the Genotoxicity of Arsenic.  ENVIRONMENTAL AND MOLECULAR MUTAGENESIS.  52:460-468.

Links between DNA polymerase beta expression and sensitivity to bleomycin.  Toxicology.  281:63-69.

[Effect of DNA polymerase beta on repair of DNA damage induced by benzo(a) pyrene]..  Wei sheng yan jiu = Journal of hygiene research.  39:13-18.

[Effects of DNA polymerase beta on certain genotoxicity of mouse fibroblast cell induced by hydroquinone]..  Wei sheng yan jiu = Journal of hygiene research.  39:669-673.

Contractions of Trinucleotide Repeats Through Base Excision Repair Attenuates Frataxin Deficiency in Friedreich's Ataxia..  ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 57-57.

DNA Base Excision Repair Capacity in Tissues of Friedreich's Ataxia Transgenic Mice..  ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 55-55.

Flap Endonuclease 1 Cleaves RNAs to Resolve R-loops Through DNA Base Excision Repair..  ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 51-52.

Oxidative DNA Damage in Parkinson's Disease-Associated Genes..  ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 75-75.

Temozolomide Attenuates Frataxin Deficiency Through Contractions of GAA Repeats Via Base Excision Repair..  ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 76-76.

miRNAs Associated With DNA Repair Are Upregulated By Environmental Toxicants..  ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 81-81.

Incorporation Of 5 ',8-Cyclodeoxyadenosine Lesions In The Promoter Region Of MiRNAs By A DNA Repair Polymerase..  ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 67-67.

R-Loops Promote Repeat Instability Through DNA Base Excision..  ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 68-68.

The Landscape of DNA Base Lesions Governs Somatic Trinucleotide Repeat Instability Through DNA Base Excision Repair..  ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 61-61.

DNA damage landscape and trinucleotide repeat instability..  ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 87-87.

Long intergenic non-coding RNA ROR is involved in arsenite-induced oxidative stress in HBE cells..  ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 95-95.

Oxidative DNA damage alters miRNA expression..  ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 61-61.

R-loops modulate trinucleotide repeat instability through DNA base excision repair..  ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 88-88.

The deoxyribose phosphate lyase of DNA polymerase beta suppresses a processive DNA synthesis to prevent trinucleotide repeat instability..  ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 89-89.

Base Excision Repair in a GAA Repeat R-loop Leads to GAA Repeats Instability..  ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S57-S57.

Identification of miRNAs and Its Target Gene Network in Mediating Arsenite-induced Malignant Transformation in Human Bronchial Epithelial Cells by miRNA Microarray Analysis.  ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S70-S71.

The Deoxyribose Phosphate Lyase Activity Of DNA Polymerase beta Prevents Trinucleotide Repeat Instability By Suppressing DNA Slippage.  ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S86-S87.

Environmentally-Induced Oxidative DNA Damage Disrupts DNA Methylation Pattern in Human Breast Cancer Type 1 (BRCA1) Gene via Base Excision Repair..  ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S62-S62.

Functional Coordination of Dual Enzymatic Activities of DNA Polymerase beta Prevents Trinucleotide Repeat Instability..  ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S70-S70.

The Deoxyribose Phosphate Lyase Activity of DNA Polymerase beta Suppresses Trinucleotide Repeat Deletions During Base Excision Repair..  ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S70-S70.

miRNA-155 Mediates Cellular Resistance to Arsenic Trioxide by Modulating Nrf2 Signaling Pathway..  ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S72-S72.

A Protective Role of Nrf2 in Arsenite-Induced Oxidative Damage is Regulated by cGMP-PKG Pathway.  ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S75-S75.

AP Endonuclease 1 Combats the Extension of a T/G Mismatch by DNA Polymerase b in CpG Dinucleotides during Base Excision Repair.  ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S62-S62.

DNA Polymerase beta R137Q Polymorphism Does Not Significantly Alter Trinucleotide Repeat Instability.  ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S63-S63.

Environmentally-Induced Oxidative DNA Damage Disrupts DNA Methylation Pattern in Human Breast Cancer Type 1 (BRCA1) Gene Promoter Region.  ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S63-S63.

Proliferating Cell Nuclear Antigen Stimulates Flap Endonuclease 1 to Modulate GAA Repeat Stability via Base Excision Repair.  ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S62-S62.

Temozolomide Upregulates Frataxin in Friedreich's Ataxia Patient Cells via Contractions of Expanded GAA Repeats.  ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S62-S62.

MSH2-MSH3 Promotes GAA Repeat Expansion by Stimulating DNA Polymerase beta Activity during Base Excision Repair.  ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S55-S55.

Resveratrol Inhibits Oxidative Damage Induced by Arsenic Trioxide.  ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S61-S61.

Base Excision Repair of Oxidative DNA Damage is Coupled with Removal of a CAG Repeat Hairpin to Attenuate Trinucleotide Repeat Expansion.  ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S30-S30.

MSH2-MSH3 Promotes GAA Repeat Expansion by Stimulating DNA Polymerase beta Activity during Base Excision Repair.  ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S30-S30.

Trinucleotide Repeat Expansion via DNA Base Lesion Repair..  ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. S32-S32.

A partial Drp1 knockout improves autophagy flux independent of mitochondrial function..  bioRxiv.

Imbalanced mitochondrial dynamics in human and mouse PD brains.

Diastereomeric Recognition of 5',8-cyclo-2'-deoxyadenosine Lesions by Human poly(ADP-ribose) Polymerase 1 in Biomimetic Model

Tyrosyl-DNA phosphodiesterase 1 and topoisomerase I activities as predictive indicators for Glioblastoma susceptibility to genotoxic agents

Trinucleotide repeat instability via DNA base excision repair.  DNA REPAIR.

Replication Stress and Consequential Instability of the Genome and Epigenome.  MOLECULES.