FIU Discovery

Optimization of the first small-molecule relaxin/insulin-like family peptide receptor (RXFP1) agonists: Activation results in an antifibrotic gene expression profile.  European Journal of Medicinal Chemistry.  156:79-92.

A CRISPR/Cas9 guidance RNA screen platform for HIV provirus disruption and HIV/AIDS gene therapy in astrocytes.  Scientific Reports.  7.

Sperm function, protein phosphorylation, and metabolism differ in mice lacking successive sperm-specific glycolytic enzymes.  Biology of Reproduction.  97:586-597.

Structural Insights into the Activation of Human Relaxin Family Peptide Receptor 1 by Small-Molecule Agonists.  Biochemistry.  55:1772-1783.

Activation of relaxin family receptor 1 from different mammalian species by relaxin peptide and small-molecule agonist ML290.  Frontiers in Endocrinology.  6.

DJ1 expression downregulates in neuroblastoma cells (SK-N-MC) chronically exposed to HIV-1 and cocaine.  Frontiers in Microbiology.  6.

Conditional Deletion of the Relaxin Receptor Gene in Cells of Smooth Muscle Lineage Affects Lower Reproductive Tract in Pregnant Mice.  Biology of Reproduction.  92.

Normal Fertility in Male Mice With Deletion of b-Catenin Gene in Germ Cells.  Genesis.  52:328-332.

NOTCH1 Gain of Function in Germ Cells Causes Failure of Spermatogenesis in Male Mice.  PLoS ONE.  8.

Identification and optimization of small-molecule agonists of the human relaxin hormone receptor RXFP1.  Nature Communications.  4.

Insulin-Like 3 Signaling Is Important for Testicular Descent but Dispensable for Spermatogenesis and Germ Cell Survival in Adult Mice.  Biology of Reproduction.  87.

Cryptorchidism in Mice with an Androgen Receptor Ablation in Gubernaculum Testis.  Molecular Endocrinology.  26:598-607.

Spermatogenesis in Cryptorchidism.  Methods in molecular biology (Clifton, N.J.).  825:127-147.

Suppression of Insulin-Like3 Receptor Reveals the Role of β-Catenin and Notch Signaling in Gubernaculum Development.  Molecular Endocrinology.  25:170-183.

Nanomedicine-based therapeutic approaches to treat methamphetamine-induced reactivation of HIV latency in the brain.  Journal of NeuroVirology. S71-S72.

Nanomedicine-based therapeutic approaches to treat methamphetamine-induced reactivation of HIV latency in the brain.  Journal of NeuroImmune Pharmacology. S71-S72.

Structural modeling of the relaxin peptide receptor and its small molecule agonists.  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.

Hormonal Regulation of Testicular Descent.  Biology of Reproduction. 55-55.

Vascular reactivity is altered in mice with a conditional knockout of relaxin receptor in endothelial cells.  The FASEB Journal.

Current application of CRISPR/Cas9 gene-editing technique to eradication of HIV/AIDS.  Gene Therapy. 377-384.