Chinnapaiyan, Srinivasan
- Assistant Professor, Cellular and Molecular Medicine , Herbert Wertheim College of Medicine
Overview
overview
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Srinivasan Chinnapaiyan mentors students in research activities at HWCOM.
Chinnapaiyan is the member of the Society for Reproductive Biology and Comparative Endocrinology, the Society for Personalized Nano-Medicine, and the American Thoracic Society. He has published several research papers in peer reviewed scientific journals and has presented his work both nationally and internationally.
Publications
Patents issued
selected scholarly works & creative activities
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Article
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2021Gene-specific MicroRNA antagonism protects against HIV Tat and TGF-β-mediated suppression of CFTR mRNA and function. Biomedicine and Pharmacotherapy. 142.Full Text via DOI: 10.1016/j.biopha.2021.112090 Web of Science: 000696926500002
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2020Novel approaches of crispr-cas technology in airway diseases. Critical Reviews in Biomedical Engineering. 48:169-176.Full Text via DOI: 10.1615/CritRevBiomedEng.2020034594
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2019TGF-β1 increases viral burden and promotes HIV-1 latency in primary differentiated human bronchial epithelial cells. Scientific Reports. 9.Full Text via DOI: 10.1038/s41598-019-49056-6 Web of Science: 000483017100031
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2019A Neutralizing Aptamer to TGFBR2 and miR-145 Antagonism Rescue Cigarette Smoke- and TGF-β-Mediated CFTR Expression. Molecular Therapy. 27:442-455.Full Text via DOI: 10.1016/j.ymthe.2018.11.017 Web of Science: 000457864300013
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2018Cigarette smoke promotes HIV infection of primary bronchial epithelium and additively suppresses CFTR function. Scientific Reports. 8.Full Text via DOI: 10.1038/s41598-018-26095-z Web of Science: 000432655800009
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2017HIV Infects Bronchial Epithelium and Suppresses Components of the Mucociliary Clearance Apparatus. PLoS ONE. 12.Full Text via DOI: 10.1371/journal.pone.0169161 Web of Science: 000391641500059
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2016Physiology of spontaneous [Ca2+]i oscillations in the isolated vasopressin and oxytocin neurones of the rat supraoptic nucleus. Cell Calcium. 59:280-288.Full Text via DOI: 10.1016/j.ceca.2016.04.001 Web of Science: 000376831800002
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2016Sodium-calcium exchanger and R-type Ca2+ channels mediate spontaneous [Ca2+]i oscillations in magnocellular neurones of the rat supraoptic nucleus. Cell Calcium. 59:289-298.Full Text via DOI: 10.1016/j.ceca.2016.03.010 Web of Science: 000376831800003
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2013Protective role of Lycopene against Aroclor 1254-induced changes on GLUT4 in the skeletal muscles of adult male rat. Drug and Chemical Toxicology. 36:320-328.Full Text via DOI: 10.3109/01480545.2012.720991 Web of Science: 000319692500008
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2013Phthalate is Associated With Insulin Resistance in Adipose Tissue of Male Rat: Role of Antioxidant Vitamins. Journal of Cellular Biochemistry. 114:558-569.Full Text via DOI: 10.1002/jcb.24399 Web of Science: 000313900600009
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2011Diethyl hexyl phthalate-induced changes in insulin signaling molecules and the protective role of antioxidant vitamins in gastrocnemius muscle of adult male rat. Toxicology and Applied Pharmacology. 257:155-164.Full Text via DOI: 10.1016/j.taap.2011.08.022 Web of Science: 000297660100001
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2011Sex steroids influence glucose oxidation through modulation of insulin receptor expression and IRS-1 serine phosphorylation in target tissues of adult male rat. Molecular and Cellular Biochemistry. 352:35-45.Full Text via DOI: 10.1007/s11010-011-0737-1 Web of Science: 000290688500005
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2009Impact of excess aldosterone on glucose homeostasis in adult male rat. Clinica Chimica Acta. 407:51-57.Full Text via DOI: 10.1016/j.cca.2009.06.030 Web of Science: 000269296800011
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Book Chapter
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2020Smart Nanogels for Biomedical Applications. 267-276.Full Text via DOI: 10.1039/bk9781782626459-00267
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Conference
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2025Interplay Between Purinergic Receptor and Nuclear Factor Kappa B in HIV Associated COPD. American Journal of Respiratory and Critical Care Medicine.Full Text via DOI: 10.1164/ajrccm.2025.211.Abstracts.A3480 Web of Science: 001488504400008
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2023Investigating the Mechanism to Develop a Therapeutic Approach to Resetting Lung Molecular Clock During HIV-Mediated COPD. Molecular Therapy. 731-731.Web of Science: 001045144203295
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2023Lactoperoxidase a Key Player in Immunity and Inflammation Upon HIV Infection and Cigarette Smoke Exposure. American Journal of Respiratory and Critical Care Medicine.Web of Science: 000995814705509
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2023Role of TGF-β in Cellular Senescence and Inflammaging by Microrna Mediated Gene Silencing. American Journal of Respiratory and Critical Care Medicine.Web of Science: 000995814707108
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2022Beneficial Effects of Quercetin in HIV-Infected Primary Human Bronchial Epithelial Cells. American Journal of Respiratory and Critical Care Medicine.Web of Science: 000792480403148
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2022Investigating the Effect of TGF-β Induced by HIV and Cigarette Smoke as a Suppressor of the Antimicrobial Agent Lactoperoxidase (LPO) in the Lungs. American Journal of Respiratory and Critical Care Medicine.Web of Science: 000792480403147
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2020HIV Tat Protein Induces the TGF-beta Signaling Pathway and Suppresses the CFTR Biogenesis and Activity by microRNA-Regulated Gene-Silencing Mechanism. The FASEB Journal.Full Text via DOI: 10.1096/fasebj.2020.34.s1.00650 Web of Science: 000546023103177
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2020Effect of TGF-Beta Induced Aberrant Micrornaomics on Cliogenesis in Primary Human Bronchial Epithelial Cells. American Journal of Respiratory and Critical Care Medicine.Web of Science: 000556622805036
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2019HIV Tat protein induced TGF-beta suppresses CFTR biogenesis and activity by microRNA mediated gene silencing. Journal of NeuroImmune Pharmacology. 340-341.Web of Science: 000468351800048
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2018HIV Tat Protein and TGF-beta Suppresses CFTR Biogenesis and Activity by Microrna Mediated Gene Silencing. American Journal of Respiratory and Critical Care Medicine.Web of Science: 000449980304442
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2017TGF-beta suppresses CFTR biogenesis and function by post-transcriptional gene silencing. Journal of NeuroImmune Pharmacology. S25-S25.Web of Science: 000414227700050
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2017Cigarette Smoke Enhances Hiv-1 Infection Of Nhbe Cells And Suppresses Cftr Function. American Journal of Respiratory and Critical Care Medicine.Web of Science: 000400372505075
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2017Tgf-Beta Suppresses Cftr Biogenesis And Function By Post-Transcriptional Gene Silencing. American Journal of Respiratory and Critical Care Medicine.Web of Science: 000400372506260
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2016EFFECT OF TOBACCO SMOKE AND HIV INFECTION ON MUCOCILIARY CLEARANCE. Journal of NeuroImmune Pharmacology. S48-S48.Web of Science: 000377566000123
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Other Scholarly Work
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2025Dual inhibition of ACE-2 and TMPRSS2: A promising strategy to mitigate SARS-CoV-2 severity in smokers. Molecular Therapy - Nucleic Acids.Full Text via DOI: 10.1016/j.omtn.2025.102662 Web of Science: 001567668700001
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Review
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2020Role of Non-Coding RNAs in Lung Circadian Clock Related Diseases. International Journal of Molecular Sciences.Full Text via DOI: 10.3390/ijms21083013 Web of Science: 000535565300355
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2019Aberrant MicroRNAomics in Pulmonary Complications: Implications in Lung Health and Diseases. Molecular Therapy - Nucleic Acids. 413-431.Full Text via DOI: 10.1016/j.omtn.2019.09.007 Web of Science: 000500716400038
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2018Aptamers in HIV research diagnosis and therapy. RNA Biology. 327-337.Full Text via DOI: 10.1080/15476286.2017.1414131 Web of Science: 000431020300005
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2015Mucociliary dysfunction in HIV and smoked substance abuse. Frontiers in Microbiology.Full Text via DOI: 10.3389/fmicb.2015.01052 Web of Science: 000363809900001
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Research
principal investigator on
- A CRISP(e)R approach to alleviating HIV-associated COPD awarded by National Heart, Lung, & Blood Institute 2024 - 2028
- Restoring mucociliary clearance apparatus to mitigate lung inflammation in the context of HIV and cigarette smoke awarded by National Institute on Drug Abuse 2022 - 2026
- Improving Airway Health in HIV Associated Lung Co-Morbidities awarded by FIU Foundation 2020 - 2022
investigator on
- A CRISP(e)R way to silence HIV awarded by Allergy and Infectious Diseases 2023 - 2028
Contact
full name
- Srinivasan Chinnapaiyan
