Becker, David

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Becker, David Graduate Faculty

Positions

Associate Professor, Chemistry and Biochemistry , College of Arts, Sciences & Education

beckerd@fiu.edu

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biography

David A. Becker is an Associate Professor in Chemistry and Biochemistry.

B.A. University of Rochester
Ph.D. Massachusetts Institute of Technology
Postdoctoral Research Associate, Columbia University

research interests

Organic Chemistry
Azulenyl nitrones
Spin Trapping
Neuroprotection
Neurodegeneration
Free radicals
Aging

Patents issued

selected scholarly works & creative activities

Article
- 2012
  
  A Peculiarly Cerebroid Convex Zygo-Dodecahedron is an Axiomatically Balanced "House of Blues": The Circle of Fifths to the Circle of Willis to Cadherin Cadenzas. SYMMETRY-BASEL. 4:644-666.
  Full Text via DOI: 10.3390/sym4040644 Web of Science: 000208832800005
- 2008
  
  Neuroprotective antioxidant STAZN protects against myocardial ischemia/reperfusion injury. BIOCHEMICAL PHARMACOLOGY. 75:448-456.
  Full Text via DOI: 10.1016/j.bcp.2007.09.001 Web of Science: 000252842300011
- 2007
  
  Neuroprotective effect of STAZN, a novel azulenyl nitrone antioxidant, in focal cerebral ischemia in rats: Dose-response and therapeutic window. BRAIN RESEARCH. 1180:101-110.
  Full Text via DOI: 10.1016/j.brainres.2007.05.028 Web of Science: 000251358300009
- 2007
  
  Stilbazulenyl nitrone decreases oxidative stress and reduces lung injury after hemorrhagic Shock/Resuscitation and LPS. ANTIOXIDANTS & REDOX SIGNALING. 9:1971-1977.
  Full Text via DOI: 10.1089/ars.2007.1765 Web of Science: 000250226500016
- 2005
  
  Neuroprotective effect of STAZN in focal cerebral ischemia: A therapeutic-window study
  Full Text via DOI: 10.1038/sj.jcbfm.9591524.0041
- 2005
  
  Stilbazulenyl nitrone, a second-generation azulenyl nitrone antioxidant, confers enduring neuroprotection in experimental focal cerebral ischemia in the rat: Neurobehavior, histopathology, and pharmacokinetics. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 313:1090-1100.
  Full Text via DOI: 10.1124/jpet.105.083386 Web of Science: 000229203200017
- 2005
  
  A novel azulenyl nitrone antioxidant protects against MPTP and 3-nitropropionic acid neurotoxicities. EXPERIMENTAL NEUROLOGY. 191:86-93.
  Full Text via DOI: 10.1016/j.expneurol.2004.07.012 Web of Science: 000226225900009
- 2004
  
  Kinetic studies on stilbazulenyl-bis-nitrone (STAZN), a nonphenolic chain-breaking antioxidant in solution, micelles, and lipid membranes. JOURNAL OF ORGANIC CHEMISTRY. 69:2929-2936.
  Full Text via DOI: 10.1021/jo030390i Web of Science: 000221268200003
- 2003
  
  Stilbazulenyl nitrone, a novel antioxidant, is highly neuroprotective in focal ischemia. ANNALS OF NEUROLOGY. 54:330-342.
  Full Text via DOI: 10.1002/ana.10659 Web of Science: 000185158100007
- 2002
  
  Stilbazulenyl nitrone, a novel azulenyl nitrone antioxidant: improved neurological deficit and reduced contusion size after traumatic brain injury in rats. JOURNAL OF NEUROSURGERY. 96:1077-1083.
  Full Text via DOI: 10.3171/jns.2002.96.6.1077 Web of Science: 000176026900024
- 2002
  
  Stilbazulenyl nitrone (STAZN): A nitronyl-substituted hydrocarbon with the potency of classical phenolic chain-breaking antioxidants. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 124:4678-4684.
  Full Text via DOI: 10.1021/ja011507s Web of Science: 000175227600036
- 2002
  
  Bicarbonate enhances peroxidase activity of Cu,Zn-superoxide dismutase: Role of carbonate anion radical and scavenging of carbonate anion radical by metalloporphyrin antioxidant enzyme mimetics. JOURNAL OF BIOLOGICAL CHEMISTRY. 277:1013-1020.
  Full Text via DOI: 10.1074/jbc.M108585200
- 1999
  
  An optimal redox status for the survival of axotomized ganglion cells in the developing retina. NEUROSCIENCE. 93:313-320.
  Full Text via DOI: 10.1016/S0306-4522(99)00138-4 Web of Science: 000081196200030
- 1998
  
  Enhanced oxygen radical production in a transgenic mouse model of familial amyotrophic lateral sclerosis. ANNALS OF NEUROLOGY. 44:763-770.
  Full Text via DOI: 10.1002/ana.410440510 Web of Science: 000076880800009
- 1998
  
  Azulenyl nitrone spin traps protect against MPTP neurotoxicity. EXPERIMENTAL NEUROLOGY. 152:163-166.
  Full Text via DOI: 10.1006/exnr.1998.6824 Web of Science: 000075127600017
- 1998
  
  Redox behaviour of azulenyl nitrones: fully reversible one electron oxidation by cyclic voltammetry at potentials in the range of biological antioxidants. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2. 1289-1291.
  Full Text via DOI: 10.1039/a708702k Web of Science: 000074273000003
- 1998
  
  Mutant Cu,Zn superoxide dismutase in motor neuron disease. AGE. 21:85-89.
  Full Text via DOI: 10.1007/s11357-998-0012-x Web of Science: 000078262100007
- 1998
  
  Azulenyl nitrones: Colorimetric detection of oxyradical end products and neuroprotection in the gerbil transient forebrain ischemia/reperfusion model. FREE RADICAL BIOLOGY AND MEDICINE. 24:738-744.
  Full Text via DOI: 10.1016/S0891-5849(97)00338-9 Web of Science: 000073018000008
- 1997
  
  Redox behaviour of azulenyl nitrones: Fully reversible one electron oxidation by cyclic voltammetry at potentials in the range of biological antioxidants. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2. 1289-1291.
- 1996
  
  Highly sensitive colorimetric detection and facile isolation of diamagnetic free radical adducts of novel chromotropic nitrone spin trapping agents readily derived from guaiazulene. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 118:905-906.
  Full Text via DOI: 10.1021/ja952895z Web of Science: A1996TT38100028
- 1993
  
  Oxocycloalkenyl isoxazolium anhydrobases: Synthesis and reactivity studies. SYNLETT. 1993:866-868.
  Full Text via DOI: 10.1055/s-1993-22636
- 1989
  
  A New Synthesis of Substituted Azulenes. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 111:389-391.
  Full Text via DOI: 10.1021/ja00183a071
- 1987
  
  Application of allenylsilanes in a regiocontrolled [3+2] annulation route to substituted isoxazoles. HETEROCYCLES. 25:277-281.
- 1982
  
  C-acylation of tertiary enolates via dithioesters
  Full Text via DOI: 10.1080/00397918208065959
Conference
- 2015
  
  Synthesis of electron rich pseudoazulenyl dinitrones exhibiting low oxidation potential. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
  Web of Science: 000432475702433
- 2013
  
  Photographic evidence for the mechanism and regiochemistry of Markovnikov and anti-Markovnikov additions of hydrogen bromide to alkenes. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
  Web of Science: 000323851301953
- 2007
  
  Design, synthesis and neuroprotective effects of azulenyl nitrone spin traps in animal models of cerebral ischemia. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
  Web of Science: 000207593906783
- 2005
  
  STAZN neuroprotection in focal cerebral ischemia in rats in terms of chronic survival and therapeutic window interval. STROKE. 471-471.
  Web of Science: 000227523800270
- 2003
  
  Neuroprotective effect of STAZN, a novel azulenyl nitrone antioxidant, in focal cerebral ischemia in rats. STROKE. 299-300.
  Web of Science: 000180251100388
- 1998
  
  Mutant CuZn superoxide dismutase in motor neuron disease. JOURNAL OF INHERITED METABOLIC DISEASE. 587-597.
  Full Text via DOI: 10.1023/A:1005475206997 Web of Science: 000075453600013
- 1997
  
  Azulenyl nitrones: Evidence for enhanced free radical scavenging as a ramification of structure and oxidation potential.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 643-ORGN.
  Web of Science: A1997WP18702088
- 1996
  
  Highly sensitive colorimetric detection and facile isolation of diamagnetic free radical adducts of novel chromotropic nitrone spin trapping agents readily derived from guaiazulene. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 426-ORGN.
  Web of Science: A1996UA48500781
- 1994
  
  STABILIZED ISOXAZOLIUM ANHYDROBASES - SYNTHESIS AND REACTIVITY STUDIES. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 151-ORGN.
  Web of Science: A1994MY95500228
Review
- 1999
  
  Diagnostic and therapeutic applications of azulenyl nitrone spin traps. CELLULAR AND MOLECULAR LIFE SCIENCES. 626-633.
  Full Text via DOI: 10.1007/s000180050457 Web of Science: 000083951400006

chaired theses and dissertations

Birudukota, Nagaraju, Design and synthesis of novel Azasteroids and Pseudoazulenyl nitrones 2016
Perez, Gloria Patricia, Synthetic Studies Toward a Novel Hydroxylamine of Potential Utility in the Preparation of Mitochondriotropic Nitrones 2016
Tamrakar, Relina, Synthesis of Azulenylsilane Nitrones as Diagnostic Tools for Superoxide Detection 2011
Kolhe, Amolkumar, Synthetic Studies of Azulenyl and Pseudoazulenyl Nitrones 2009

principal investigator on

Preparation Synthesis and Protocols Preparation of Samples Including Azulenyl Nitrones for Radiation Detection awarded by GEX Corporation 2013 - 2014
Azulenyl Nitrones: Neuroprotectants in Stroke and Trauma - 2005-2006 awarded by Neurological Disorders and Stroke 2005 - 2006

full name

David Becker

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