Aggarwal, Saurabh

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Aggarwal, Saurabh Graduate Faculty

Positions

Associate Professor, Department of Cellular and Molecular Medicine , Herbert Wertheim College of Medicine

saaggarw@fiu.edu

selected scholarly works & creative activities

Article
- 2026
  
  Beyond respiratory depression: acute and delayed pulmonary responses following aerosolized fentanyl exposure. TOXICOLOGICAL SCIENCES. 209.
  Full Text via DOI: 10.1093/toxsci/kfag081
- 2026
  
  Acute toxicity and sex-dependent lethality of isotonitazene in fischer 344 rats. FRONTIERS IN TOXICOLOGY. 8.
  Full Text via DOI: 10.3389/ftox.2026.1818684 Web of Science: 001739687500001
- 2026
  
  Social Determinants of Health and Pediatric Long COVID in the US. JAMA pediatrics. 180:275-287.
  Full Text via DOI: 10.1001/jamapediatrics.2025.5485
- 2025
  
  Inhalation exposure to dihydroxyacetone promotes lung injury and pulmonary fibrosis in A/J mice. Toxicology Reports. 14.
  Full Text via DOI: 10.1016/j.toxrep.2024.101878
- 2025
  
  Oxidative damage to lung mitochondrial DNA is a key contributor to the development of chemical lung injury. REDOX BIOLOGY. 82.
  Full Text via DOI: 10.1016/j.redox.2025.103624 Web of Science: 001468705600001
- 2025
  
  Restoration of pp60^Src Re-Establishes Electron Transport Chain Complex I Activity in Pulmonary Hypertensive Endothelial Cells. International Journal of Molecular Sciences. 26.
  Full Text via DOI: 10.3390/ijms26083815 Web of Science: 001476535100001
- 2025
  
  Mitochondrial fission produces a Warburg effect via the oxidative inhibition of prolyl hydroxylase domain-2. REDOX BIOLOGY. 81.
  Full Text via DOI: 10.1016/j.redox.2025.103529 Web of Science: 001430070500001
- 2025
  
  Biomarkers to Differentiate Acute Chest Syndrome From Vaso-Occlusive Crisis in Children With Sickle Cell Disease. European Journal of Haematology. 114:325-333.
  Full Text via DOI: 10.1111/ejh.14342 Web of Science: 001358448900001
- 2025
  
  Chloroquine Restores eNOS Signaling in Shunt Endothelial Cells via Inhibiting eNOS Uncoupling. International Journal of Molecular Sciences. 26.
  Full Text via DOI: 10.3390/ijms26031352 Web of Science: 001418638500001
- 2025
  
  Comprehensive Physicochemical Characterization and in Vitro Human Cell Culture Studies of an Innovative Biocompatible and Biodegradable Silk-Derived Protein Hydrolysate, SDP-4. ACS OMEGA. 10:2762-2777.
  Full Text via DOI: 10.1021/acsomega.4c08514 Web of Science: 001398584600001
- 2025
  
  Drp1-associated genes implicated in sepsis survival. FRONTIERS IN IMMUNOLOGY. 15.
  Full Text via DOI: 10.3389/fimmu.2024.1516145 Web of Science: 001400996700001
- 2024
  
  The mitochondrial redistribution of ENOS is regulated by AKT1 and dimer status. Nitric Oxide - Biology and Chemistry. 152:90-100.
  Full Text via DOI: 10.1016/j.niox.2024.09.009 Web of Science: 001333933500001
- 2024
  
  Advanced Spray-Dried Inhalable Microparticles/Nanoparticles of an Innovative Mitophagy Activator for Targeted Lung Delivery: Design, Comprehensive Characterization, Human Lung Cell Culture, and In Vitro Aerosol Dispersion Performance. ACS Pharmacology and Translational Science. 7:3540-3558.
  Full Text via DOI: 10.1021/acsptsci.4c00436 Web of Science: 001333365300001
- 2024
  
  Characterizing Long COVID in Children and Adolescents. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION. 332:1174-1188.
  Full Text via DOI: 10.1001/jama.2024.12747 Web of Science: 001296852900002
- 2024
  
  Inflammatory lung injury is associated with endothelial cell mitochondrial fission and requires the nitration of RhoA and cytoskeletal remodeling. FREE RADICAL BIOLOGY AND MEDICINE. 221:125-135.
  Full Text via DOI: 10.1016/j.freeradbiomed.2024.05.019 Web of Science: 001264208500001
- 2024
  
  Free Radical-Associated Gene Signature Predicts Survival in Sepsis Patients. International Journal of Molecular Sciences. 25.
  Full Text via DOI: 10.3390/ijms25084574 Web of Science: 001210024800001
- 2024
  
  Mitochondrial network dynamics in pulmonary disease: Bridging the gap between inflammation, oxidative stress, and bioenergetics. REDOX BIOLOGY. 70.
  Full Text via DOI: 10.1016/j.redox.2024.103049 Web of Science: 001176158200001
- 2024
  
  Mitochondrial hyperfusion induces metabolic remodeling in lung endothelial cells by modifying the activities of electron transport chain complexes I and III. FREE RADICAL BIOLOGY AND MEDICINE. 210:183-194.
  Full Text via DOI: 10.1016/j.freeradbiomed.2023.11.008 Web of Science: 001129100700001
- 2023
  
  Novel Relationship between Mitofusin 2-Mediated Mitochondrial Hyperfusion, Metabolic Remodeling, and Glycolysis in Pulmonary Arterial Endothelial Cells. International Journal of Molecular Sciences. 24.
  Full Text via DOI: 10.3390/ijms242417533 Web of Science: 001131445000001
- 2023
  
  Assessment of pain-related behaviors in HIV-1 transgenic rats as a model of HIV-associated chronic pain. Molecular Pain. 19.
  Full Text via DOI: 10.1177/17448069231213554 Web of Science: 001100113500001
- 2023
  
  Sex-Based Disparities in Leukocyte Migration and Activation in Response to Inhalation Lung Injury: Role of SDF-1/CXCR4 Signaling. CELLS. 12.
  Full Text via DOI: 10.3390/cells12131719 Web of Science: 001028348400001
- 2023
  
  Heme-Induced Macrophage Phenotype Switching and Impaired Endogenous Opioid Homeostasis Correlate with Chronic Widespread Pain in HIV. CELLS. 12.
  Full Text via DOI: 10.3390/cells12121565 Web of Science: 001093450700001
- 2023
  
  High Heme and Low Heme Oxygenase-1 Are Associated with Mast Cell Activation/Degranulation in HIV-Induced Chronic Widespread Pain. Antioxidants. 12.
  Full Text via DOI: 10.3390/antiox12061213 Web of Science: 001016850300001
- 2022
  
  TCT-604 Outcomes in Single vs Double Perclose ProGlide Device Technique During Transfemoral Transcatheter Aortic Valve Implantation: Meta-Analysis. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 80:b248.
  Full Text via DOI: 10.1016/j.jacc.2022.08.713
- 2022
  
  NF-κB-dependent repression of Sox18 transcription factor requires the epigenetic regulators histone deacetylases 1 and 2 in acute lung injury. Frontiers in Physiology. 13.
  Full Text via DOI: 10.3389/fphys.2022.947537 Web of Science: 000842859100001
- 2021
  
  AICAR decreases acute lung injury by phosphorylating AMPK and upregulating heme oxygenase-1. EUROPEAN RESPIRATORY JOURNAL. 58.
  Full Text via DOI: 10.1183/13993003.03694-2020 Web of Science: 000744140100024
- 2021
  
  External versus internal cardioversion for atrial fibrillation: a meta-analysis of randomized controlled trials. Journal of Interventional Cardiac Electrophysiology. 61:445-451.
  Full Text via DOI: 10.1007/s10840-020-00836-5 Web of Science: 000554328300001
- 2021
  
  Chlorine inhalation induces acute chest syndrome in humanized sickle cell mouse model and ameliorated by postexposure hemopexin. REDOX BIOLOGY. 44.
  Full Text via DOI: 10.1016/j.redox.2021.102009 Web of Science: 000663416500011
- 2021
  
  Nitration of protein kinase G-Iα modulates cyclic nucleotide crosstalk via phosphodiesterase 3A: Implications for acute lung injury. Journal of Biological Chemistry. 297.
  Full Text via DOI: 10.1016/j.jbc.2021.100946 Web of Science: 000690871000011
- 2021
  
  LPS decreases CFTR open probability and mucociliary transport through generation of reactive oxygen species. REDOX BIOLOGY. 43.
  Full Text via DOI: 10.1016/j.redox.2021.101998 Web of Science: 000657009900002
- 2021
  
  Temporal Trends, Predictors, and Outcomes of Acute Ischemic Stroke in Acute Myocardial Infarction in the United States. JOURNAL OF THE AMERICAN HEART ASSOCIATION. 10.
  Full Text via DOI: 10.1161/JAHA.120.017693 Web of Science: 000610049900026
- 2021
  
  Disparities in case frequency and mortality of coronavirus disease 2019 (COVID-19) among various states in the United States. Annals of Medicine. 53:151-159.
  Full Text via DOI: 10.1080/07853890.2020.1840620 Web of Science: 000585381300001
- 2021
  
  Factors associated with deep venous thrombosis in patients infected with coronavirus disease 2019: a meta-analysis. BLOOD COAGULATION & FIBRINOLYSIS. 32:23-28.
  Full Text via DOI: 10.1097/MBC.0000000000000974 Web of Science: 000661965500004
- 2021
  
  RAC1 nitration at Y³² IS involved in the endothelial barrier disruption associated with lipopolysaccharide-mediated acute lung injury. REDOX BIOLOGY. 38.
  Full Text via DOI: 10.1016/j.redox.2020.101794 Web of Science: 000604901500006
- 2021
  
  Subcutaneouscardiac Rhythm Monitors: A Comprehensive Review.. Journal of Atrial Fibrillation. 13:2387.
  Full Text via DOI: 10.4022/jafib.2387
- 2020
  
  Abstract 14739: Temporal Trends, Predictors and Outcomes of Acute Ischemic Stroke in Acute Myocardial Infarction in the United States. CIRCULATION. 142.
  Full Text via DOI: 10.1161/circ.142.suppl_3.14739
- 2020
  
  Heme attenuates beta-endorphin levels in leukocytes of HIV positive individuals with chronic widespread pain. REDOX BIOLOGY. 36.
  Full Text via DOI: 10.1016/j.redox.2020.101684 Web of Science: 000571097100007
- 2020
  
  Reactive species generated by heme impair alveolar epithelial sodium channel function in acute respiratory distress syndrome. REDOX BIOLOGY. 36.
  Full Text via DOI: 10.1016/j.redox.2020.101592 Web of Science: 000572165300004
- 2020
  
  Cardiovascular Safety of Potential Drugs for the Treatment of Coronavirus Disease 2019. AMERICAN JOURNAL OF CARDIOLOGY. 128:147-150.
  Full Text via DOI: 10.1016/j.amjcard.2020.04.054 Web of Science: 000547812800022
- 2020
  
  Vascular permeability disruption explored in the proteomes of mouse lungs and human microvascular cells following acute bromine exposure. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. 319:L337-L359.
  Full Text via DOI: 10.1152/ajplung.00196.2020 Web of Science: 000561480000014
- 2020
  
  Clinical features, laboratory characteristics, and outcomes of patients hospitalized with coronavirus disease 2019 (COVID-19): Early report from the United States. Diagnosis. 7:91-96.
  Full Text via DOI: 10.1515/dx-2020-0046 Web of Science: 000531038000004
- 2020
  
  Vascular Endothelial Growth Factor-121 Administration Mitigates Halogen Inhalation-Induced Pulmonary Injury and Fetal Growth Restriction in Pregnant Mice. JOURNAL OF THE AMERICAN HEART ASSOCIATION. 9.
  Full Text via DOI: 10.1161/JAHA.119.013238 Web of Science: 000522242500010
- 2020
  
  Suicide Attempt as the Presenting Symptom in a Patient with COVID-19: A Case Report from the United States. Case Reports in Psychiatry. 2020.
  Full Text via DOI: 10.1155/2020/8897454
- 2019
  
  Phosgene inhalation causes hemolysis and acute lung injury. TOXICOLOGY LETTERS. 312:204-213.
  Full Text via DOI: 10.1016/j.toxlet.2019.04.019 Web of Science: 000471234200021
- 2018
  
  Heme scavenging reduces pulmonary endoplasmic reticulum stress, fibrosis, and emphysema. JCI insight. 3.
  Full Text via DOI: 10.1172/jci.insight.120694 Web of Science: 000449225900002
- 2018
  
  Instillation of hyaluronan reverses acid instillation injury to the mammalian blood gas barrier. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. 314:L808-L821.
  Full Text via DOI: 10.1152/ajplung.00510.2017 Web of Science: 000440950700011
- 2018
  
  LPS-induced Acute Lung Injury Involves NF-κB-mediated Downregulation of SOX18. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. 58:614-624.
  Full Text via DOI: 10.1165/rcmb.2016-0390OC Web of Science: 000431198400015
- 2018
  
  Bromine Exposure In Pregnant Mice May Reduce VEGF Signaling Via Increased Circulating VEGF Decoy Receptor sFlt‐1. FASEB JOURNAL. 32:729.2-729.2.
  Full Text via DOI: 10.1096/fasebj.2018.32.1_supplement.729.2
- 2018
  
  Exposure of neonatal mice to bromine impairs their alveolar development and lung function. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. 314:L137-L143.
  Full Text via DOI: 10.1152/ajplung.00315.2017 Web of Science: 000418930100012
- 2017
  
  Mechanisms and Treatment of Halogen Inhalation-Induced Pulmonary and Systemic Injuries in Pregnant Mice. Hypertension. 70:390-+.
  Full Text via DOI: 10.1161/HYPERTENSIONAHA.117.09466 Web of Science: 000405299100033
- 2017
  
  A STUDY TO COMPARE THE CLINICAL FEATURES BETWEEN POST PULMONARY TUBERCULOSIS ASSOCIATED CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) WITH OTHER COPD PATIENTS. Journal of Evolution of Medical and Dental Sciences. 6:7015-7019.
  Full Text via DOI: 10.14260/jemds/2017/1522 Web of Science: 000419217600020
- 2017
  
  Hyper-activation of pp60^Src limits nitric oxide signaling by increasing asymmetric dimethylarginine levels during acute lung injury. FREE RADICAL BIOLOGY AND MEDICINE. 102:217-228.
  Full Text via DOI: 10.1016/j.freeradbiomed.2016.11.008 Web of Science: 000392361200018
- 2016
  
  Differential regulation of autophagy and mitophagy in pulmonary diseases. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. 311:L433-L452.
  Full Text via DOI: 10.1152/ajplung.00128.2016 Web of Science: 000381628600022
- 2016
  
  Spectrum of mucocutaneous manifestations in an Asian cohort of patients with leukemia. INTERNATIONAL JOURNAL OF DERMATOLOGY. 55:893-897.
  Full Text via DOI: 10.1111/ijd.13157 Web of Science: 000380353000024
- 2016
  
  Redox regulation of epidermal growth factor receptor signaling during the development of pulmonary hypertension. FREE RADICAL BIOLOGY AND MEDICINE. 95:96-111.
  Full Text via DOI: 10.1016/j.freeradbiomed.2016.02.029 Web of Science: 000376169800009
- 2016
  
  Synthesis and biological evaluation of 3-tetrazolo steroidal analogs: Novel class of 5α-reductase inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY. 24:779-788.
  Full Text via DOI: 10.1016/j.bmc.2015.12.048 Web of Science: 000368898500028
- 2016
  
  Heme Attenuation Ameliorates Irritant Gas Inhalation-Induced Acute Lung Injury. ANTIOXIDANTS & REDOX SIGNALING. 24:99-112.
  Full Text via DOI: 10.1089/ars.2015.6347 Web of Science: 000368448000004
- 2016
  
  Chlorine-induced cardiopulmonary injury. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 1374:159-167.
  Full Text via DOI: 10.1111/nyas.13091 Web of Science: 000379428500018
- 2016
  
  Role of heme in bromine-induced lung injury. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 1374:105-110.
  Full Text via DOI: 10.1111/nyas.13086 Web of Science: 000379428500012
- 2015
  
  Upregulation of autophagy decreases chlorine-induced mitochondrial injury and lung inflammation. FREE RADICAL BIOLOGY AND MEDICINE. 85:83-94.
  Full Text via DOI: 10.1016/j.freeradbiomed.2015.03.039 Web of Science: 000358198000008
- 2015
  
  Abstract 90: Akt Mediated Mitochondrial Dysfunction Involves Mitochondrial Endothelial Nitric Oxide Synthase Translocation. CIRCULATION RESEARCH. 117.
  Full Text via DOI: 10.1161/res.117.suppl_1.90
- 2015
  
  Influenza virus M2 targets cystic fibrosis transmembrane conductance regulator for lysosomal degradation during viral infection. FASEB JOURNAL. 29:2712-2725.
  Full Text via DOI: 10.1096/fj.14-268755 Web of Science: 000356859100004
- 2015
  
  Hyaluronan mediates airway hyperresponsiveness in oxidative lung injury. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. 308:L891-L903.
  Full Text via DOI: 10.1152/ajplung.00377.2014 Web of Science: 000353928100004
- 2015
  
  Endothelial Nitric Oxide Synthase Deficient Mice Are Protected from Lipopolysaccharide Induced Acute Lung Injury. PLOS ONE. 10.
  Full Text via DOI: 10.1371/journal.pone.0119918 Web of Science: 000352138500143
- 2015
  
  The Targon FN System for the Management of Intracapsular Neck of Femur Fractures: Minimum 2-Year Experience and Outcome in an Independent Hospital. CiOS Clinics in Orthopedic Surgery. 7:22-28.
  Full Text via DOI: 10.4055/cios.2015.7.1.22 Web of Science: 000433719300004
- 2014
  
  Sox18 Preserves the Pulmonary Endothelial Barrier Under Conditions of Increased Shear Stress. Journal of Cellular Physiology. 229:1802-1816.
  Full Text via DOI: 10.1002/jcp.24633 Web of Science: 000341646000025
- 2014
  
  PKC-Dependent Phosphorylation of eNOS at T495 Regulates eNOS Coupling and Endothelial Barrier Function in Response to G⁺ -Toxins. PLOS ONE. 9.
  Full Text via DOI: 10.1371/journal.pone.0099823 Web of Science: 000339618600004
- 2014
  
  Endothelin-1 Induces a Glycolytic Switch in Pulmonary Arterial Endothelial Cells via the Mitochondrial Translocation of Endothelial Nitric Oxide Synthase. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. 50:1084-1095.
  Full Text via DOI: 10.1165/rcmb.2013-0187OC Web of Science: 000336832400009
- 2014
  
  The Over-Expression of Sox18 Attenuates the Development of Acute Lung Injury. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 189:a5328-a5328.
  Full Text via DOI: 10.1164/ajrccm-conference.2014.189.1_meetingabstracts.a5328
- 2014
  
  A survey of breakthrough therapy designations. NATURE BIOTECHNOLOGY. 32:323-330.
  Full Text via DOI: 10.1038/nbt.2864 Web of Science: 000334340800013
- 2014
  
  Nitration of Tyrosine 247 Inhibits Protein Kinase G-1α Activity by Attenuating Cyclic Guanosine Monophosphate Binding. Journal of Biological Chemistry. 289:7948-7961.
  Full Text via DOI: 10.1074/jbc.M113.534313 Web of Science: 000332761500059
- 2014
  
  Dimethylarginine Dimethylaminohydrolase II Overexpression Attenuates LPS-Mediated Lung Leak in Acute Lung Injury. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. 50:614-625.
  Full Text via DOI: 10.1165/rcmb.2013-0193OC Web of Science: 000332513500014
- 2014
  
  Limbal dermoid in Nager acrofacial dysostosis: A rare case report. Indian Journal of Ophthalmology. 62.
  Full Text via DOI: 10.4103/0301-4738.111194 Web of Science: 000348549500018
- 2014
  
  Lipopolysaccharide- induced Lung Injury Involves the Nitration- mediated Activation of RhoA*. Journal of Biological Chemistry. 289:4710-4722.
  Full Text via DOI: 10.1074/jbc.M114.547596 Web of Science: 000331607900018
- 2014
  
  Endothelin-1 stimulates catalase activity through the PKCδ-mediated phosphorylation of serine 167. FREE RADICAL BIOLOGY AND MEDICINE. 67:255-264.
  Full Text via DOI: 10.1016/j.freeradbiomed.2013.10.814 Web of Science: 000331854200024
- 2014
  
  Protein engineering to develop a redox insensitive endothelial nitric oxide synthase. REDOX BIOLOGY. 2:156-164.
  Full Text via DOI: 10.1016/j.redox.2013.12.015 Web of Science: 000350769600020
- 2014
  
  What's fueling the biotech engine-2012 to 2013. NATURE BIOTECHNOLOGY. 32:32-39.
  Full Text via DOI: 10.1038/nbt.2794 Web of Science: 000329513000012
- 2013
  
  Reactive Oxygen Species in Pulmonary Vascular Remodeling. Comprehensive Physiology. 3:1011-1034.
  Full Text via DOI: 10.1002/cphy.c120024 Web of Science: 000324524400001
- 2013
  
  Reactive Oxygen Species in Pulmonary Vascular Remodeling. Comprehensive Physiology. 3:1011-1034.
  Full Text via DOI: 10.1002/j.2040-4603.2013.tb00518.x
- 2013
  
  Disruption of Endothelial Cell Mitochondrial Bioenergetics in Lambs with Increased Pulmonary Blood Flow. ANTIOXIDANTS & REDOX SIGNALING. 18:1739-1752.
  Full Text via DOI: 10.1089/ars.2012.4806 Web of Science: 000317099700004
- 2013
  
  In-Stent Restenosis in the Superficial Femoral Artery. Annals of Vascular Surgery. 27:510-524.
  Full Text via DOI: 10.1016/j.avsg.2012.09.005 Web of Science: 000318464700016
- 2013
  
  Chronic inhibition of PPAR-γ signaling induces endothelial dysfunction in the juvenile lamb. PULMONARY PHARMACOLOGY & THERAPEUTICS. 26:271-280.
  Full Text via DOI: 10.1016/j.pupt.2012.12.004 Web of Science: 000317149100015
- 2013
  
  Asymmetric Dimethylarginine Induces Endothelial Nitric-oxide Synthase Mitochondrial Redistribution through the Nitration-mediated Activation of Akt1. Journal of Biological Chemistry. 288:6212-6226.
  Full Text via DOI: 10.1074/jbc.M112.423269 Web of Science: 000315820700017
- 2013
  
  Bosentan inhibits oxidative and nitrosative stress and rescues occlusive pulmonary hypertension. FREE RADICAL BIOLOGY AND MEDICINE. 56:28-43.
  Full Text via DOI: 10.1016/j.freeradbiomed.2012.09.013 Web of Science: 000319647700004
- 2013
  
  Tezosentan increases nitric oxide signaling via enhanced hydrogen peroxide generation in lambs with surgically induced acute increases in pulmonary blood flow. JOURNAL OF CELLULAR BIOCHEMISTRY. 114:435-447.
  Full Text via DOI: 10.1002/jcb.24383 Web of Science: 000312651400021
- 2013
  
  Role of Carnitine Acetyl Transferase in Regulation of Nitric Oxide Signaling in Pulmonary Arterial Endothelial Cells. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 14:255-272.
  Full Text via DOI: 10.3390/ijms14010255 Web of Science: 000314048800016
- 2013
  
  Rosiglitazone preserves pulmonary vascular function in lambs with increased pulmonary blood flow. PEDIATRIC RESEARCH. 73:54-61.
  Full Text via DOI: 10.1038/pr.2012.149 Web of Science: 000313307900009
- 2012
  
  Increased NADPH oxidase-derived superoxide is involved in the neuronal cell death induced by hypoxia-ischemia in neonatal hippocampal slice cultures. FREE RADICAL BIOLOGY AND MEDICINE. 53:1139-1151.
  Full Text via DOI: 10.1016/j.freeradbiomed.2012.06.012 Web of Science: 000308624700012
- 2012
  
  Synthesis and biological evaluation of novel unsaturated carboxysteroids as human 5α-reductase inhibitors: A legitimate approach. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 54:728-739.
  Full Text via DOI: 10.1016/j.ejmech.2012.06.026 Web of Science: 000307920600075
- 2012
  
  Glutathione supplementation attenuates lipopolysaccharide-induced mitochondrial dysfunction and apoptosis in a mouse model of acute lung injury. Frontiers in Physiology. 3.
  Full Text via DOI: 10.3389/fphys.2012.00161 Web of Science: 000209173000158
- 2012
  
  Neuroprotective Effect of Cyclooxygenase Inhibitors in ICV-STZ Induced Sporadic Alzheimer's Disease in Rats. Journal of Molecular Neuroscience. 46:223-235.
  Full Text via DOI: 10.1007/s12031-011-9583-6 Web of Science: 000299332200025
- 2011
  
  Purification and functional analysis of protein kinase G-1α using a bacterial expression system. Protein Expression and Purification. 79:271-276.
  Full Text via DOI: 10.1016/j.pep.2011.05.001 Web of Science: 000294098000016
- 2011
  
  Assessment of biological half life using in silico QSPkR approach: A self organizing molecular field analysis (SOMFA) on a series of antimicrobial quinolone drugs. International Journal of Pharmaceutics. 415:158-163.
  Full Text via DOI: 10.1016/j.ijpharm.2011.05.065 Web of Science: 000293304900020
- 2010
  
  Ligand Based 3D-QSAR Study on a Series of Steroidal Human 5α-Reductase Inhibitors. Letters in Drug Design and Discovery. 7:596-601.
  Full Text via DOI: 10.2174/157018010792062795 Web of Science: 000280474200005
- 2010
  
  3D QSAR Studies on 1, 3, 4-Thiadiazole Derivatives: An Approach to Design Novel Anticonvulsants. Medicinal Chemistry. 6:233-238.
  Full Text via DOI: 10.2174/1573406411006040233 Web of Science: 000289267800007
- 2010
  
  Self-Organizing Molecular Field Analysis on Pyridazine Analogues as Protein Tyrosine Phosphatase 1B (PTP 1B) Inhibitors. Letters in Drug Design and Discovery. 7:395-401.
  Full Text via DOI: 10.2174/157018010791306605 Web of Science: 000277887000002
- 2010
  
  Self-organizing molecular field analysis of 2,4-thiazolidinediones: A 3D-QSAR model for the development of human PTP1B inhibitors. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 45:2537-2546.
  Full Text via DOI: 10.1016/j.ejmech.2010.02.042 Web of Science: 000278056000051
- 2010
  
  Self-organizing molecular field analysis on pregnane derivatives as human steroidal 5α-reductase inhibitors. STEROIDS. 75:411-418.
  Full Text via DOI: 10.1016/j.steroids.2010.02.005 Web of Science: 000277670100005
- 2010
  
  Sulphonamides as Inhibitors of Protein Tyrosine Phosphatase 1B: A Three-Dimensional Quantitative Structure-Activity Relationship Study Using Self-Organizing Molecular Field Analysis Approach. Chemical and Pharmaceutical Bulletin. 58:526-532.
  Full Text via DOI: 10.1248/cpb.58.526 Web of Science: 000276065200018
- 2010
  
  3D-QSAR studies on unsaturated 4-azasteroids as human 5α-reductase inhibitors: A self organizing molecular field analysis approach. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 45:476-481.
  Full Text via DOI: 10.1016/j.ejmech.2009.10.030 Web of Science: 000274773300008
- 2010
  
  3D-QSAR Studies on a Series of 5-Arylidine-2, 4-Thiazolidinediones as Aldose Reductase Inhibitors: A Self-Organizing Molecular Field Analysis Approach. Medicinal Chemistry. 6:30-36.
  Full Text via DOI: 10.2174/157340610791208718 Web of Science: 000276405800005
- 2010
  
  Synthesis and In Vitro Evaluation of Novel 1, 2, 4-Triazole Derivatives as Antifungal Agents. Letters in Drug Design and Discovery. 7:46-49.
  Full Text via DOI: 10.2174/157018010789869415 Web of Science: 000272791000011
- 2009
  
  Effect of PPARγ inhibition on pulmonary endothelial cell gene expression: gene profiling in pulmonary hypertension. Physiological Genomics. 40:48-60.
  Full Text via DOI: 10.1152/physiolgenomics.00094.2009 Web of Science: 000273181800006
- 2009
  
  Self organizing molecular field analysis on a series of human 5α-reductase inhibitors: Unsaturated 3-carboxysteroid. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 44:4920-4925.
  Full Text via DOI: 10.1016/j.ejmech.2009.08.004 Web of Science: 000272928600014
- 2009
  
  GTP cyclohydrolase I expression is regulated by nitric oxide: role of cyclic AMP. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. 297:L309-L317.
  Full Text via DOI: 10.1152/ajplung.90538.2008 Web of Science: 000268276200012
- 2009
  
  Targeting the cancer stroma with a fibroblast activation protein-activated promelittin protoxin. MOLECULAR CANCER THERAPEUTICS. 8:1378-1386.
  Full Text via DOI: 10.1158/1535-7163.MCT-08-1170 Web of Science: 000266189900041
- 2008
  
  Fibroblast activation protein peptide substrates identified from human collagen I derived gelatin cleavage sites. BIOCHEMISTRY. 47:1076-1086.
  Full Text via DOI: 10.1021/bi701921b Web of Science: 000252415500023
- 2006
  
  A dimeric peptide that binds selectively to prostate-specific membrane antigen and inhibits its enzymatic activity. CANCER RESEARCH. 66:9171-9177.
  Full Text via DOI: 10.1158/0008-5472.CAN-06-1520 Web of Science: 000240650300033
- 2006
  
  Comparative study of PSMA expression in the prostate of mouse, dog, monkey, and human. PROSTATE. 66:903-910.
  Full Text via DOI: 10.1002/pros.20413 Web of Science: 000237839700002
- 2006
  
  Insights into US public biotech sector using patenting trends. NATURE BIOTECHNOLOGY. 24:643-651.
  Full Text via DOI: 10.1038/nbt0606-643 Web of Science: 000238187300021
- Mechanisms of nitric oxide synthase uncoupling in endotoxin-induced acute lung injury: Role of asymmetric dimethylarginine. Vascular Pharmacology. 52:182-190.
  Full Text via DOI: 10.1016/j.vph.2009.11.010 Web of Science: 000277447100003
- QSAR STUDIES ON HUMAN 5α-REDUCTASE INHIBITORS: UNSATURATED 3-CARBOXYSTEROIDS. Acta Poloniae Pharmaceutica. 68:447-452.
  Web of Science: 000294185500018
- The lectin-like domain of TNF protects from listeriolysin-induced hyperpermeability in human pulmonary microvascular endothelial cells - A crucial role for protein kinase C-α inhibition. Vascular Pharmacology. 52:207-213.
  Full Text via DOI: 10.1016/j.vph.2009.12.010 Web of Science: 000277447100006
Book Chapter
- 2015
  
  Pulmonary Hemodynamics. 205-243.
  Full Text via DOI: 10.1016/B978-0-12-404577-4.00014-X
- 2015
  
  Chapter 14 Pulmonary Hemodynamics. 205-243.
  Full Text via DOI: 10.1016/b978-0-12-404577-4.00014-x
- 2014
  
  Endothelial dysfunction in acute lung injury. 27-49.
- 2014
  
  Oxidative Stress and Pulmonary Vascular Disorders. 457-480.
  Full Text via DOI: 10.1007/978-1-4939-0679-6_27 Web of Science: 000341237400027
Conference
- 2026
  
  Mitophagy Activator Urolithin A Attenuates Lung Cell Injury. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.
  Full Text via DOI: 10.1093/ajrccm/aamag162.5354 Web of Science: 001769273300031
- 2025
  
  Sub Chronic, Low Dose Exposure to Dihydroxyacetone Causes Changes to Cardiac Metabolism and Induces DNA Damage. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 106-106.
  Web of Science: 001572124600048
- 2025
  
  INDIRECT TREATMENT COMPARISON FOR EARLY EFFICACY OF VMAT2 INHIBITORS FOR TARDIVE DYSKINESIA AND CHOREA ASSOCIATED WITH HUNTINGTON'S DISEASE. VALUE IN HEALTH. S43-S43.
  Web of Science: 001543678800157
- 2025
  
  Therapeutic Effects of Topical Silk-Derived Protein 4 Formulation on Chloropicrin-Injured Mouse Cornea and Ex-vivo Rabbit Cornea. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE.
  Web of Science: 001560034400033
- 2024
  
  Dihydroxyacetone Exposures Induce Genotoxicity and Metabolic Reprogramming in Cardiac Myocytes. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 104-104.
  Web of Science: 001364266600182
- 2024
  
  Biomarkers to Determine the Onset of Acute Chest Syndrome Versus Vaso-occlusive Crisis in Children With Sickle Cell Disease. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.
  Web of Science: 001277228901624
- 2023
  
  Effects of Semaglutide on Metabolic Syndrome Parameters in Non-Diabetics: A Meta-analysis of Randomized Controlled Trials. Metabolism: Clinical and Experimental. S22-S22.
  Full Text via DOI: 10.1016/j.metabol.2023.155462 Web of Science: 001020660400050
- 2023
  
  EFFICACY OF LOW- LEVEL LIGHT THERAPY FOR TREATMENT OF ANDROGENETIC ALOPECIA: A META- ANALYSIS. LASERS IN SURGERY AND MEDICINE. S143-S143.
  Web of Science: 001042980400194
- 2023
  
  Orbital Atherectomy During Percutaneous Coronary Intervention for Severely Calcified Coronary Lesions in Patients With and Without Diabetes Mellitus: A Meta-Analysis. JACC: Cardiovascular Interventions. S3-S3.
  Web of Science: 000995481700007
- 2023
  
  Transcatheter Aortic Valve Replacement With Self-Expanding Acurate Neo2 Valve Versus Acurate Neo Valve: A Meta-Analysis. JACC: Cardiovascular Interventions. S88-S89.
  Web of Science: 000995481700220
- 2023
  
  Transcatheter Aortic Valve Replacement in Patients With and Without Concomitant Aortic Aneurysm: A Meta-Analysis. JACC: Cardiovascular Interventions. S96-S97.
  Web of Science: 000995481700239
- 2022
  
  Outcomes in Single vs Double Perclose ProGlide Device Technique During Transfemoral Transcatheter Aortic Valve Implantation: Meta-Analysis. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. B248-B248.
  Web of Science: 000892594000563
- 2022
  
  OUTCOMES IN ST-ELEVATION MYOCARDIAL INFARCTION PATIENTS WITH AND WITHOUT USE OF INTRAVASCULAR ULTRASOUND: META-ANALYSIS. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 940-940.
  Web of Science: 000781026601041
- 2022
  
  SEX DIFFERENCES IN LEFT ATRIAL APPENDAGE OCCLUSION OUTCOMES: META-ANALYSIS. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 884-884.
  Web of Science: 000781026600883
- 2020
  
  Temporal Trends, Predictors and Outcomes of Acute Ischemic Stroke in Acute Myocardial Infarction in the United States. CIRCULATION.
  Web of Science: 000607190402198
- 2020
  
  A SYSTEMATIC REVIEW OF STUDIES ON DEFIBROTIDE PROPHYLAXIS FOR VENO-OCCLUSIVE DISEASE/SINUSOIDAL OBSTRUCTION SYNDROME (VOD/SOS). PEDIATRIC BLOOD & CANCER. S230-S231.
  Web of Science: 000530720700438
- 2020
  
  TRENDS IN EMERGENCY DEPARTMENT USE IN PATIENTS DIAGNOSED WITH HYPERKALAEMIA: AN ANALYSIS OF A US NATIONAL EMERGENCY DEPARTMENT DATABASE. NEPHROLOGY DIALYSIS TRANSPLANTATION. 1108-1108.
  Web of Science: 000562392101235
- 2020
  
  Gp120/CXCR4 axis promotes uncoupling of NOS3 in HIV smokers. Antiviral Therapy. 25-25.
  Web of Science: 000750440600017
- 2020
  
  NATIONAL TRENDS IN HOSPITALIZATIONS, MORTALITY AND COST OF CARE AMONG ACUTE MYOCARDIAL INFARCTION PATIENTS IN THE UNITED STATES: NATIONWIDE INPATIENT SAMPLE FROM 2001 TO 2014. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 250-250.
  Web of Science: 000522979100246
- 2020
  
  TRENDS IN EMERGENCY DEPARTMENT VISITS AND COST FOR ORTHOSTATIC HYPOTENSION IN THE UNITED STATES. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2065-2065.
  Web of Science: 000522979102050
- 2020
  
  A Meta-Analysis Evaluating the Risk of Bleeding-Related Adverse Events with Defibrotide Treatment. Transplantation and Cellular Therapy. S131-S131.
  Web of Science: 000516887900184
- 2020
  
  A Systematic Review of Studies of Defibrotide Prophylaxis for Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome. Transplantation and Cellular Therapy. S133-S133.
  Web of Science: 000516887900188
- 2020
  
  Gp120/CXCR4 axis promotes uncoupling of NOS3 in HIV smokers. Antiviral Therapy. A25-A25.
  Web of Science: 000649401100017
- 2019
  
  Cigarette smoking disproportionately impairs nitric oxide signaling in pulmonary artery endothelial cells in HIV: role of viral and host factors. HIV Medicine. 146-146.
  Web of Science: 000494690300307
- 2019
  
  ISOLATED DIASTOLIC HYPERTENSION IN THE UNITED STATES: ANALYSIS FROM THE NATIONAL HEALTH AND NUTRITION EXAMINATION SURVEY. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 1892-1892.
  Full Text via DOI: 10.1016/S0735-1097(19)32498-2 Web of Science: 000460565901904
- 2019
  
  Exposure of Neonatal Mice to Bromine Gas Inhibits Lung Development: Heme Antagonism to the Rescue. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.
  Web of Science: 000466771100025
- 2019
  
  Histone Deacetylases 1 and 2 Play Essential Roles in the Lipopolysaccharide (LPS) Dependent Disruption of the Endothelial Barrier via the Repression of the Transcription Factor Sox18. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.
  Web of Science: 000466776705117
- 2019
  
  Mitochondrial DNA Repair Ameliorates Inhalation Lung Injury. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.
  Web of Science: 000466771100022
- 2019
  
  VEGF-121 Therapy Mitigates Halogen Inhalation-Induced Injury in Pregnant Mice. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.
  Web of Science: 000466771101144
- 2018
  
  The tyrosine nitration of PKG-1 alpha inhibits its regulatory function in the pulmonary endothelium. FREE RADICAL BIOLOGY AND MEDICINE. S46-S46.
  Full Text via DOI: 10.1016/j.freeradbiomed.2018.10.074 Web of Science: 000449083900097
- 2018
  
  Pooled Analysis of Defibrotide Studies in Treatment of Adult Patients with Veno-occlusive Disease/Sinusoidal Obstruction Syndrome after Hematopoietic Stem Cell Transplantation (HSCT) or Chemotherapy Without HSCT. Bone Marrow Transplantation. 63-64.
  Web of Science: 000487702800048
- 2018
  
  A meta-analysis of efficacy and safety of Watchman device for left atrial appendage closure in non-valvular atrial fibrillation. EUROPEAN HEART JOURNAL. 818-818.
  Web of Science: 000459824002586
- 2018
  
  A metaanlysis for safety and efficacy of amplatzer cardiac plug and amulet device for left atrial appendage closure in patiets with non valvular atrial fibrillation. EUROPEAN HEART JOURNAL. 818-818.
  Web of Science: 000459824002587
- 2018
  
  POOLED ANALYSIS OF DEFIBROTIDE STUDIES IN TREATMENT OF PEDIATRIC PATIENTS WITH VENO-OCCLUSIVE DISEASE/SINUSOIDAL OBSTRUCTION SYNDROME (VOD/SOS) AFTER HEMATOPOIETIC STEM CELL TRANSPLANTATION (HSCT) OR CHEMOTHERAPY WITHOUT HSCT. PEDIATRIC BLOOD & CANCER.
  Web of Science: 000428851200488
- 2018
  
  Bromine Exposure In Pregnant Mice May Reduce VEGF Signaling Via Increased Circulating VEGF Decoy Receptor sFlt-1. FASEB JOURNAL.
  Web of Science: 000436986705219
- 2018
  
  Tyrosine Nitration of Protein Kinase G-1a Disrupts Cyclic Nucleotide Cross-Talk and Is Involved in the Development of Acute Lung Injury. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.
  Web of Science: 000449978902072
- 2017
  
  Pooled Analysis of Defibrotide Studies in the Treatment of Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome (VOD/SOS) after Hematopoietic Stem Cell Transplantation (HSCT) or Chemotherapy without HSCT. BLOOD.
  Web of Science: 000432419706175
- 2017
  
  Diagnostic performance of Fractional Flow Reserve derived from Computed Tomography compared to Invasive Coronary Angiography derived Fractional Flow Reserve. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. B75-B75.
  Full Text via DOI: 10.1016/j.jacc.2017.09.243 Web of Science: 000413459200175
- 2017
  
  Impact of coronary artery disease on clinical outcomes after transcatheter aortic valve replacement. EUROPEAN HEART JOURNAL. 622-622.
  Web of Science: 000440509302403
- 2017
  
  Low Molecular Weight Hyaluronan Mediates Acid Aspiration Induced Acute Lung Injury in Mice. ANESTHESIA AND ANALGESIA. 196-196.
  Web of Science: 000412683000099
- 2017
  
  SEQUENTIAL INHIBITION OF RENIN-ANGIOTENSIN SYSTEM IN HEART FAILURE IS ASSOCIATED WITH ENHANCED NET BENEFIT AT A COST OF INCREASED ADVERSE EVENTS: A SYSTEMATIC META-ANALYSIS. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 918-918.
  Full Text via DOI: 10.1016/S0735-1097(17)34307-3 Web of Science: 000397342301440
- 2016
  
  Trends in Usage and Outcomes Associated With Ultrafiltration in Hospitalized Patients With Congestive Heart Failure. CIRCULATION.
  Web of Science: 000396815603113
- 2016
  
  Contemporary trends of hospitalizations for acute decompensated heart failure in the US from 2008 to 2012. EUROPEAN HEART JOURNAL. 45-45.
  Web of Science: 000383869500140
- 2016
  
  Impact of obstructive sleep apnea on outcomes in patients undergoing transcatheter aortic valve replacement. EUROPEAN HEART JOURNAL. 560-560.
  Web of Science: 000383869502529
- 2016
  
  Ultrafiltration Versus Intravenous Diuretics for Treatment of Acute Decompensated Heart Failure Versus Intravenous Diuretics for Treatment of Acute Decompensated Heart Failure. Journal of Cardiac Failure. S61-S61.
  Web of Science: 000381064700162
- 2015
  
  Concomitant Left Atrial Appendage Closure During Cardiac Surgery: A Meta-analysis. CIRCULATION.
  Web of Science: 000209846307025
- 2015
  
  Akt Mediated Mitochondrial Dysfunction Involves Mitochondrial Endothelial Nitric Oxide Synthase Translocation. CIRCULATION RESEARCH.
  Web of Science: 000374552800085
- 2015
  
  PREVALENCE OF CARDIOVASCULAR EVENTS IN PATIENTS WITH CANCER: ANALYSIS OF 12-YEAR DATA FROM NATIONAL HEALTH AND NUTRITION EXAMINATION SURVEY 1999-2010. JOURNAL OF GENERAL INTERNAL MEDICINE. S235-S235.
  Web of Science: 000358386901041
- 2014
  
  Everolimus versus Mycophenolate for Cardiac Transplantation. CIRCULATION.
  Web of Science: 000209790207236
- 2014
  
  Short Term Outcomes After Use of Bone Marrow Transplantation for Management of Heart Failure: A Meta-analysis. CIRCULATION.
  Web of Science: 000209800300023
- 2014
  
  Trends in Incidence, Invasive Management and Outcomes of Cardiogenic Shock Complicating Non ST-Segment Elevation Myocardial Infarction. CIRCULATION.
  Web of Science: 000209800305184
- 2014
  
  Trends in Incidence, Management and Outcomes of Heart Failure Patients with Cardiogenic Shock. CIRCULATION.
  Web of Science: 000209800302049
- 2014
  
  Stimulation of pp60^Src activity limits nitric oxide signaling through increases in asymmetric dimethylarginine. EUROPEAN RESPIRATORY JOURNAL.
  Web of Science: 000209782503175
- 2013
  
  Reaching AHA 2020 Impact Goal for Cholesterol - Effect of Lifestyle Modification Counselling. CIRCULATION.
  Web of Science: 000332162904474
- 2013
  
  pp60(Src) Limits Nitric Oxide Signaling through Increases in Asymmetric Dimethylarginine. FREE RADICAL BIOLOGY AND MEDICINE. S100-S100.
  Full Text via DOI: 10.1016/j.freeradbiomed.2013.10.641 Web of Science: 000209475700238
- 2012
  
  Daily Coffe Consumption Does Not Impact All-Cause or Specific Cardiovascular Mortality: Findings from the National Health and Nutrition Examination Survey. CIRCULATION.
  Web of Science: 000208885004226
- 2012
  
  National Trends of Lifestyle Modification Counseling for Hyperlipidemia -Analyses from National Health and Nutrition Examination Survey Databases 1999-2010. CIRCULATION.
  Web of Science: 000208885008022
- 2012
  
  Water Consumption Does not Influence All Cause or Cardiovascular Mortality: A Followup Study of Patients in the National Health and Nutrition Examination Survey. CIRCULATION.
  Web of Science: 000208885008001
- 2012
  
  Asymmetric Dimethylarginine (ADMA) Mediated Activation of Akt1 Signaling in Endothelial Cells. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. a4824-a4824.
  Full Text via DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a4824
- 2012
  
  Ligand-Independent EGFR Activation in the Development Pulmonary Hypertension. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. a4758-a4758.
  Full Text via DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a4758
- 2012
  
  Sox18 and the Regulation of Endothelial Barrier Function in Acute Lung Injury. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. a6716-a6716.
  Full Text via DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a6716
- 2012
  
  Hsp90 inhibition prevents bacterial lipopolysaccharide-induced and RhoA- mediated signaling leading to paracellular hyper-permeability in human lung microvascular endothelial cells. FASEB JOURNAL.
  Web of Science: 000310711303323
- 2011
  
  Post-Translational Regulation of RhoA and RaC1. FREE RADICAL BIOLOGY AND MEDICINE. S114-S114.
  Full Text via DOI: 10.1016/j.freeradbiomed.2011.10.357 Web of Science: 000297036600292
- 2011
  
  Role of Epidermal Growth Factor Receptor Autophosphorylation in Pulmonary Hypertension Development. FREE RADICAL BIOLOGY AND MEDICINE. S114-S115.
  Full Text via DOI: 10.1016/j.freeradbiomed.2011.10.359 Web of Science: 000297036600294
- 2011
  
  The Anti-Proliferative Effect of Bosentan in Occlusive Pulmonary Hypertension Involves a Reduction in Both Oxidative and Nitrosative Stress. FREE RADICAL BIOLOGY AND MEDICINE. S114-S114.
  Full Text via DOI: 10.1016/j.freeradbiomed.2011.10.358 Web of Science: 000297036600293
- 2011
  
  Glutathione Supplementation Attenuates Inflammation and Improves Lung Mechanics in a Murine Model of Acute Lung Injury. FASEB JOURNAL.
  Web of Science: 000310708401351
- 2011
  
  LPS-Induced Hyper-permeability in Human Lung Microvascular Endothelial Cells (HLMVEC) Involves the Nitration-Mediated Activation of RhoA. FASEB JOURNAL.
  Web of Science: 000310708401352
- 2011
  
  Nitration-Mediated Inhibition Of Protein Kinase G Is Involved In The Barrier Disruptive Effects Of Lipopolysaccaharide. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.
  Web of Science: 000208770303712
- 2010
  
  LPS decreases dimethylarginine dimethylaminohydrolase (DDAH) activity through the activation of pp60Src.. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.
  Web of Science: 000208771005095
- 2010
  
  LPS-induced hyper-permeability of human lung microvascular endothelial cells (HLMVEC) involves the nitration-mediated activation of RhoA. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.
  Web of Science: 000208771002728
- 2010
  
  Ligand Independent Up-regulation of EGFR Signaling is Responsible for eNOS Dysfunction in Pulmonary Hypertension. FREE RADICAL BIOLOGY AND MEDICINE. S49-S49.
  Full Text via DOI: 10.1016/j.freeradbiomed.2010.10.107 Web of Science: 000284348000126
- 2010
  
  Nitration-mediated Activation of RhoA: Its Role in LPS-induced Endothelial Barrier Dysfunction. FREE RADICAL BIOLOGY AND MEDICINE. S49-S49.
  Full Text via DOI: 10.1016/j.freeradbiomed.2010.10.106 Web of Science: 000284348000125
- 2010
  
  The Rebound Pulmonary Hypertension Associated with the Acute Withdrawal of Inhaled Nitric Oxide involves the Nitration-Mediated Inhibition of Protein Kinase G: Protective Role of Superoxide Dismutase. FREE RADICAL BIOLOGY AND MEDICINE. S14-S14.
  Full Text via DOI: 10.1016/j.freeradbiomed.2010.10.002 Web of Science: 000284348000023
- 2009
  
  Identification of Tyrosine 247 as the Site of PKG, Susceptible to Peroxynitrite-Mediated Nitration during the Development of Pulmonary Hypertension. FREE RADICAL BIOLOGY AND MEDICINE. S53-S53.
  Web of Science: 000271988500143
Letter
- 2020
  
  Residual Shunt After Patent Foramen Ovale Closure and Long-Term Stroke Recurrence. Annals of Internal Medicine. 945-945.
  Full Text via DOI: 10.7326/L20-1269 Web of Science: 000595140400022
- 2020
  
  Sleep Duration and Cardiovascular Disease Prevalence - The Debate Continues. AMERICAN JOURNAL OF CARDIOLOGY. 159-159.
  Full Text via DOI: 10.1016/j.amjcard.2020.05.023 Web of Science: 000547812800024
- Disseminated cutaneous leiomyomatosis treated with oral amlodipine. INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY.
  Full Text via DOI: 10.4103/0378-6323.104694 Web of Science: 000313292900034
Other Scholarly Work
- 2025
  
  Targeting the SDF-1/CXCR4 axis to attenuate pain in sickle cell disease: A preclinical evaluation of AMD3100 as a non-opioid therapeutic strategy. BLOOD.
  Full Text via DOI: 10.1182/blood-2025-4715 Web of Science: 001663651800015
- 2025
  
  Ventilator-induced Lung Injury Associated With Endothelial Cell Mitochondrial Fission. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.
  Full Text via DOI: 10.1164/ajrccm.2025.211.Abstracts.A2890 Web of Science: 001488513600004
- 2022
  
  A reference human induced pluripotent stem cell line for large-scale collaborative studies.. Cell Stem Cell. 1685-1702.e22.
  Full Text via DOI: 10.1016/j.stem.2022.11.004
- 2022
  
  Role of Mast Cells in HIV-associated Chronic Widespread Pain. Journal of Pain. 3-3.
  Web of Science: 000792497000010
- 2019
  
  AMPK Activation Improves Survivability after Toxic Gas Exposure. FASEB JOURNAL.
  Web of Science: 000495951200163
- 2018
  
  Can a Vitamin a Day Keep Tuberculosis Away?. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. 523-524.
  Full Text via DOI: 10.1165/rcmb.2018-0198ED Web of Science: 000448968200001
- 2018
  
  Brominated Lipid Adducts Cause Hemolysis and Exacerbate Pulmonary and Systemic Injury Post Bromine Exposure. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.
  Web of Science: 000449980301386
- 2018
  
  Bromine Exposure In Pregnant Mice May Reduce VEGF Signaling. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.
  Web of Science: 000449980301383
- 2018
  
  Elevated Free Heme Predisposes to Bacterial Lung Infection After Acute Inhalation Injury. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.
  Web of Science: 000449978904512
- 2018
  
  Role of Mitochondrial DNA Damage in Aberrant Airway Remodeling and Repair Post Inhalation Lung Injury. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.
  Web of Science: 000449980305344
- 2017
  
  Activation Of Unfolded Protein Response In Br2 Inhalation Injury-Induced Pulmonary Fibrosis. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.
  Web of Science: 000400372504046
- 2017
  
  Novel Insights Into Decreased Innate Immunity In Acute Lung Injury: Role Of Heme. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.
  Web of Science: 000400372504424
- 2016
  
  Bromine Inhalation in Pregnant Mice Induces Systemic and Pulmonary Hypertension, Fetal Growth Restriction, Heart Failure and Death. FASEB JOURNAL.
  Web of Science: 000406444705332
- 2016
  
  Development Of Pulmonary Fibrosis Following Bromine Inhalation Injury. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.
  Web of Science: 000390749602260
- 2016
  
  Tadalafil Ameliorates Halogen- Inhalation Injury During Pregnancy. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.
  Web of Science: 000390749600186
- 2016
  
  The Central Role Of Heme In The Propagation Of Bacterial Infection After Acute Lung Injury. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.
  Web of Science: 000390749607041
- 2015
  
  Heme Dependent Mitochondrial Stress And Apoptosis Are Hallmarks Of Bromine Toxicity. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.
  Web of Science: 000377582806097
- 2015
  
  Heme Scavenging Ameliorates Bromine Induced Lung Injury. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.
  Web of Science: 000377582803504
- 2015
  
  Pregnant Mice Exposed To Bromine Are Susceptible To Preeclampsia And Increased Maternal Mortality. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.
  Web of Science: 000377582806098
- 2014
  
  Heme Scavenging Attenuates Bromine Induced Lung Injury. FREE RADICAL BIOLOGY AND MEDICINE. S77-S77.
  Full Text via DOI: 10.1016/j.freeradbiomed.2014.10.274 Web of Science: 000359525800188
- 2014
  
  Role of Carboxyl-Terminal Modulator Protein in the Nitration Mediated Activation of Akt1. FREE RADICAL BIOLOGY AND MEDICINE. S166-S166.
  Full Text via DOI: 10.1016/j.freeradbiomed.2014.10.055 Web of Science: 000359525800425
- 2013
  
  Erratum: Rosiglitazone preserves pulmonary vascular function in lambs with increased pulmonary blood flow (Pediatric Research (2013) 73 (54-61) DOI: 10.1038/pr.2012.149). PEDIATRIC RESEARCH. 742.
  Full Text via DOI: 10.1038/pr.2013.171
- 2013
  
  Rosiglitazone preserves pulmonary vascular function in lambs with increased pulmonary blood flow (vol 73, pg 54, 2013). PEDIATRIC RESEARCH. 742-742.
  Web of Science: 000329560000017
- 2011
  
  Nitration Mediated Activation of Akt Involved in Endothelial Nitric Oxide Synthase (eNOS) Mitochondria Translocation. FREE RADICAL BIOLOGY AND MEDICINE. S139-S139.
  Full Text via DOI: 10.1016/j.freeradbiomed.2011.10.296 Web of Science: 000297036600362
- 2009
  
  What's fueling the biotech engine-2007 (vol 26, pg 1227, 2008). NATURE BIOTECHNOLOGY. 205-205.
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- 2009
  
  What's fueling the biotech engine-2007 (vol 26, pg 1227, 2008). NATURE BIOTECHNOLOGY. 205-205.
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  Insights into US public biotech sector using patenting trends (vol 24, pg 643, 2006). NATURE BIOTECHNOLOGY. 1033-1033.
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Preprint
- 2024
  
  Oxidative Injury to Lung Mitochondrial DNA is a Key Contributor for the Development of Chemical Lung Injury.
  Full Text via DOI: 10.1101/2024.11.22.624949
- 2020
  
  Heme Attenuates Endogenous Opioid Levels in Leukocytes of HIV positive individuals with Chronic Widespread Pain
  Full Text via DOI: 10.1101/2020.04.24.059790
- 2020
  
  Heme Impairs Alveolar Epithelial Sodium Channels Post Toxic Gas Inhalation
  Full Text via DOI: 10.1101/2020.01.22.909879
- 2019
  
  Phosgene Inhalation Causes Hemolysis and Acute Lung Injury
  Full Text via DOI: 10.1101/521724
- A reference induced pluripotent stem cell line for large-scale collaborative studies
  Full Text via DOI: 10.1101/2021.12.15.472643
- Disparities in Case Frequency and Mortality of Coronavirus Disease 2019 (COVID-19) Among Various States in the United States
  Full Text via DOI: 10.1101/2020.07.28.20163931
- Evolving Paradigms in Cancer Pain Management: From Opioid-Centric Care to Multimodal and Personalized Strategies
  Full Text via DOI: 10.20944/preprints202603.1978.v1
Review
- 2026
  
  The evolving epidemiology of opioid use disorder: polysubstance use, drug supply transformation, and policy implications. FRONTIERS IN PUBLIC HEALTH.
  Full Text via DOI: 10.3389/fpubh.2026.1861122 Web of Science: 001882540000001
- 2026
  
  Molecular Clocks in Translational Roadmap for Circadian-Based Therapeutics in Lung Diseases. FASEB JOURNAL.
  Full Text via DOI: 10.1096/fj.202504876R Web of Science: 001773971600001
- 2026
  
  Evolving Paradigms in Cancer Pain Management: From Opioid-Centric Care to Multimodal and Personalized Strategies. CANCERS.
  Full Text via DOI: 10.3390/cancers18091476 Web of Science: 001763312600001
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  Dr. Jekyll or Mr. Hyde: The multifaceted roles of miR-145-5p in human health and disease. Non-coding RNA Research. 22-37.
  Full Text via DOI: 10.1016/j.ncrna.2024.11.001 Web of Science: 001378982800001
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  Recent advances in nanotherapeutics for HIV-associated neurocognitive disorders and substance use disorders. Nanomedicine. 603-619.
  Full Text via DOI: 10.1080/17435889.2025.2461984 Web of Science: 001424396700001
- 2024
  
  Recent advances in nanogels for drug delivery and biomedical applications. Biomaterials Science.
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- 2022
  
  Serum biomarkers for prediction of mortality in patients with COVID-19. Annals of Clinical Biochemistry. 15-22.
  Full Text via DOI: 10.1177/00045632211014244 Web of Science: 000652309400001
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  Halogen-Induced Chemical Injury to the Mammalian Cardiopulmonary Systems. Physiology. 272-291.
  Full Text via DOI: 10.1152/physiol.00004.2021 Web of Science: 000697498700003
- 2020
  
  Hyaluronan and halogen-induced airway hyperresponsiveness and lung injury. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 29-43.
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- 2020
  
  Association of Cardiovascular Disease With Coronavirus Disease 2019 (COVID-19) Severity: A Meta-Analysis. Current Problems in Cardiology.
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  Chronic Pain in HIV. Molecular Pain.
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- 2018
  
  The staged management of gleno-humeral joint osteonecrosis in patients with haematological-induced disease-a cohort review. International Orthopaedics. 1651-1659.
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  Role of apoptosis and autophagy in tuberculosis. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. L218-L229.
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  An Overview of Phytotherapeutic Approaches for the Treatment of Benign Prostatic Hyperplasia. MINI-REVIEWS IN MEDICINAL CHEMISTRY. 257-270.
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- 2012
  
  Protein Tyrosine Phosphatase 1B Inhibitors: A Molecular Level Legitimate Approach for the Management of Diabetes Mellitus. Medicinal Research Reviews. 459-517.
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  Screening for celiac disease in average-risk and high-risk populations. Therapeutic Advances in Gastroenterology. 37-47.
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  Attenuated Vasodilatation in Lambs with Endogenous and Exogenous Activation of cGMP Signaling: Role of Protein Kinase G Nitration. Journal of Cellular Physiology. 3104-3113.
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  Oxidative Stress and the Development of Endothelial Dysfunction in Congenital Heart Disease With Increased Pulmonary Blood Flow: Lessons From the Neonatal Lamb. TRENDS IN CARDIOVASCULAR MEDICINE. 238-246.
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  Saxagliptin: A New Drug for the Treatment of Type 2 Diabetes. MINI-REVIEWS IN MEDICINAL CHEMISTRY. 759-765.
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  An overview on 5α-reductase inhibitors. STEROIDS. 109-153.
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principal investigator on

Chronic Widespread Pain in HIV: Novel Mechanisms and Therapeutics awarded by National Institute on Drug Abuse 2024 - 2027
Uncovering the Mechanisms of Pain Relief by Peripheral Magnetic Stimulation (PMS) awarded by Baptist Health South Florida 2025 - 2026
Identification of AMD3100 (Plerixafor) as a lead compound for chlorine toxicity awarded by Environmental Health Sciences 2024 - 2025

full name

Saurabh Aggarwal

ORCID iD

https://orcid.org/0000-0001-7192-1569 (confirmed)
https://orcid.org/0000-0002-6273-0346 (confirmed)
https://orcid.org/0000-0002-3059-1193 (confirmed)

visualizations

Co-author Network

Co-investigator Network