Aggarwal, Saurabh
- Associate Professor, Cellular and Molecular Medicine , Herbert Wertheim College of Medicine
Publications
selected scholarly works & creative activities
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Article
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2025Inhalation exposure to dihydroxyacetone promotes lung injury and pulmonary fibrosis in A/J mice. Toxicology Reports. 14.Full Text via DOI: 10.1016/j.toxrep.2024.101878
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2025Oxidative damage to lung mitochondrial DNA is a key contributor to the development of chemical lung injury. Redox Biology. 82.Full Text via DOI: 10.1016/j.redox.2025.103624 Web of Science: 001468705600001
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2025Biomarkers to Differentiate Acute Chest Syndrome From Vaso-Occlusive Crisis in Children With Sickle Cell Disease. European Journal of Haematology. 114:325-333.Full Text via DOI: 10.1111/ejh.14342 Web of Science: 001358448900001
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2025Comprehensive Physicochemical Characterization and in Vitro Human Cell Culture Studies of an Innovative Biocompatible and Biodegradable Silk-Derived Protein Hydrolysate, SDP-4. ACS Omega. 10:2762-2777.Full Text via DOI: 10.1021/acsomega.4c08514 Web of Science: 001398584600001
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2024Advanced Spray-Dried Inhalable Microparticles/Nanoparticles of an Innovative Mitophagy Activator for Targeted Lung Delivery: Design, Comprehensive Characterization, Human Lung Cell Culture, and In Vitro Aerosol Dispersion Performance. ACS Pharmacology and Translational Science. 7:3540-3558.Full Text via DOI: 10.1021/acsptsci.4c00436 Web of Science: 001333365300001
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2023Assessment of pain-related behaviors in HIV-1 transgenic rats as a model of HIV-associated chronic pain. Molecular Pain. 19.Full Text via DOI: 10.1177/17448069231213554 Web of Science: 001100113500001
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2023Sex-Based Disparities in Leukocyte Migration and Activation in Response to Inhalation Lung Injury: Role of SDF-1/CXCR4 Signaling. Cells. 12.Full Text via DOI: 10.3390/cells12131719 Web of Science: 001028348400001
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2023Heme-Induced Macrophage Phenotype Switching and Impaired Endogenous Opioid Homeostasis Correlate with Chronic Widespread Pain in HIV. Cells. 12.Full Text via DOI: 10.3390/cells12121565 Web of Science: 001093450700001
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2023High Heme and Low Heme Oxygenase-1 Are Associated with Mast Cell Activation/Degranulation in HIV-Induced Chronic Widespread Pain. Antioxidants. 12.Full Text via DOI: 10.3390/antiox12061213 Web of Science: 001016850300001
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2021AICAR decreases acute lung injury by phosphorylating AMPK and upregulating heme oxygenase-1. European Respiratory Journal. 58.Full Text via DOI: 10.1183/13993003.03694-2020 Web of Science: 000744140100024
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2021Chlorine inhalation induces acute chest syndrome in humanized sickle cell mouse model and ameliorated by postexposure hemopexin. Redox Biology. 44.Full Text via DOI: 10.1016/j.redox.2021.102009 Web of Science: 000663416500011
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2021LPS decreases CFTR open probability and mucociliary transport through generation of reactive oxygen species. Redox Biology. 43.Full Text via DOI: 10.1016/j.redox.2021.101998 Web of Science: 000657009900002
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2020Heme attenuates beta-endorphin levels in leukocytes of HIV positive individuals with chronic widespread pain. Redox Biology. 36.Full Text via DOI: 10.1016/j.redox.2020.101684 Web of Science: 000571097100007
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2020Reactive species generated by heme impair alveolar epithelial sodium channel function in acute respiratory distress syndrome. Redox Biology. 36.Full Text via DOI: 10.1016/j.redox.2020.101592 Web of Science: 000572165300004
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2020Vascular permeability disruption explored in the proteomes of mouse lungs and human microvascular cells following acute bromine exposure. American Journal of Physiology - Lung Cellular and Molecular Physiology. 319:L337-L359.Full Text via DOI: 10.1152/ajplung.00196.2020 Web of Science: 000561480000014
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2020Vascular Endothelial Growth Factor-121 Administration Mitigates Halogen Inhalation-Induced Pulmonary Injury and Fetal Growth Restriction in Pregnant Mice. Journal of the American Heart Association. 9.Full Text via DOI: 10.1161/JAHA.119.013238 Web of Science: 000522242500010
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2019Phosgene inhalation causes hemolysis and acute lung injury. Toxicology Letters. 312:204-213.Full Text via DOI: 10.1016/j.toxlet.2019.04.019 Web of Science: 000471234200021
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2018Heme scavenging reduces pulmonary endoplasmic reticulum stress, fibrosis, and emphysema. JCI insight. 3.Full Text via DOI: 10.1172/jci.insight.120694 Web of Science: 000449225900002
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2018Instillation of hyaluronan reverses acid instillation injury to the mammalian blood gas barrier. American Journal of Physiology - Lung Cellular and Molecular Physiology. 314:L808-L821.Full Text via DOI: 10.1152/ajplung.00510.2017 Web of Science: 000440950700011
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2018Bromine Exposure In Pregnant Mice May Reduce VEGF Signaling Via Increased Circulating VEGF Decoy Receptor sFlt‐1. The FASEB Journal. 32:729.2-729.2.Full Text via DOI: 10.1096/fasebj.2018.32.1_supplement.729.2
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2018Exposure of neonatal mice to bromine impairs their alveolar development and lung function. American Journal of Physiology - Lung Cellular and Molecular Physiology. 314:L137-L143.Full Text via DOI: 10.1152/ajplung.00315.2017 Web of Science: 000418930100012
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2017Mechanisms and Treatment of Halogen Inhalation-Induced Pulmonary and Systemic Injuries in Pregnant Mice. Hypertension. 70:390-+.Full Text via DOI: 10.1161/HYPERTENSIONAHA.117.09466 Web of Science: 000405299100033
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2016Differential regulation of autophagy and mitophagy in pulmonary diseases. American Journal of Physiology - Lung Cellular and Molecular Physiology. 311:L433-L452.Full Text via DOI: 10.1152/ajplung.00128.2016 Web of Science: 000381628600022
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2016Bromine Inhalation in Pregnant Mice Induces Systemic and Pulmonary Hypertension, Fetal Growth Restriction, Heart Failure and Death. The FASEB Journal. 30.Full Text via DOI: 10.1096/fasebj.30.1_supplement.954.6
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2016Heme Attenuation Ameliorates Irritant Gas Inhalation-Induced Acute Lung Injury. Antioxidants and Redox Signaling. 24:99-112.Full Text via DOI: 10.1089/ars.2015.6347 Web of Science: 000368448000004
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2016Chlorine-induced cardiopulmonary injury. Annals of the New York Academy of Sciences. 1374:159-167.Full Text via DOI: 10.1111/nyas.13091 Web of Science: 000379428500018
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2016Role of heme in bromine-induced lung injury. Annals of the New York Academy of Sciences. 1374:105-110.Full Text via DOI: 10.1111/nyas.13086 Web of Science: 000379428500012
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2015Upregulation of autophagy decreases chlorine-induced mitochondrial injury and lung inflammation. Free Radical Biology and Medicine. 85:83-94.Full Text via DOI: 10.1016/j.freeradbiomed.2015.03.039 Web of Science: 000358198000008
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2015Influenza virus M2 targets cystic fibrosis transmembrane conductance regulator for lysosomal degradation during viral infection. The FASEB Journal. 29:2712-2725.Full Text via DOI: 10.1096/fj.14-268755 Web of Science: 000356859100004
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2015Hyaluronan mediates airway hyperresponsiveness in oxidative lung injury. American Journal of Physiology - Lung Cellular and Molecular Physiology. 308:L891-L903.Full Text via DOI: 10.1152/ajplung.00377.2014 Web of Science: 000353928100004
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Conference
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2019Exposure of Neonatal Mice to Bromine Gas Inhibits Lung Development: Heme Antagonism to the Rescue. American Journal of Respiratory and Critical Care Medicine.Web of Science: 000466771100025
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2019VEGF-121 Therapy Mitigates Halogen Inhalation-Induced Injury in Pregnant Mice. American Journal of Respiratory and Critical Care Medicine.Web of Science: 000466771101144
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2018Bromine Exposure In Pregnant Mice May Reduce VEGF Signaling Via Increased Circulating VEGF Decoy Receptor sFlt-1. The FASEB Journal.Web of Science: 000436986705219
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Other Scholarly Work
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2022Role of Mast Cells in HIV-associated Chronic Widespread Pain. Journal of Pain. 3-3.Web of Science: 000792497000010
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2019AMPK Activation Improves Survivability after Toxic Gas Exposure. The FASEB Journal.Web of Science: 000495951200163
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2018Can a Vitamin a Day Keep Tuberculosis Away?. American Journal of Respiratory Cell and Molecular Biology. 523-524.Full Text via DOI: 10.1165/rcmb.2018-0198ED Web of Science: 000448968200001
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2014Heme Scavenging Attenuates Bromine Induced Lung Injury. Free Radical Biology and Medicine. S77-S77.Full Text via DOI: 10.1016/j.freeradbiomed.2014.10.274 Web of Science: 000359525800188
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2014Role of Carboxyl-Terminal Modulator Protein in the Nitration Mediated Activation of Akt1. Free Radical Biology and Medicine. S166-S166.Full Text via DOI: 10.1016/j.freeradbiomed.2014.10.055 Web of Science: 000359525800425
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Preprint
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2020Heme Impairs Alveolar Epithelial Sodium Channels Post Toxic Gas InhalationFull Text via DOI: 10.1101/2020.01.22.909879
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Review
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2025Recent advances in nanotherapeutics for HIV-associated neurocognitive disorders and substance use disorders. Nanomedicine. 603-619.Full Text via DOI: 10.1080/17435889.2025.2461984 Web of Science: 001424396700001
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2024Recent advances in nanogels for drug delivery and biomedical applications. Biomaterials Science.Full Text via DOI: 10.1039/d4bm00224e Web of Science: 001345745400001
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2021Halogen-Induced Chemical Injury to the Mammalian Cardiopulmonary Systems. Physiology. 272-291.Full Text via DOI: 10.1152/physiol.00004.2021 Web of Science: 000697498700003
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2020Hyaluronan and halogen-induced airway hyperresponsiveness and lung injury. Annals of the New York Academy of Sciences. 29-43.Full Text via DOI: 10.1111/nyas.14415 Web of Science: 000542112200001
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2020Chronic Pain in HIV. Molecular Pain.Full Text via DOI: 10.1177/1744806920927276 Web of Science: 000538427300001
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2017Role of apoptosis and autophagy in tuberculosis. American Journal of Physiology - Lung Cellular and Molecular Physiology. L218-L229.Full Text via DOI: 10.1152/ajplung.00162.2017 Web of Science: 000406746900003
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Research
principal investigator on
- Chronic Widespread Pain in HIV: Novel Mechanisms and Therapeutics awarded by National Institute on Drug Abuse 2024 - 2026
- Uncovering the Mechanisms of Pain Relief by Peripheral Magnetic Stimulation (PMS) awarded by Baptist Health South Florida 2025 - 2026
- Identification of AMD3100 (Plerixafor) as a lead compound for chlorine toxicity awarded by Environmental Health Sciences 2024 - 2025
Contact
full name
- Saurabh Aggarwal
