The mission of the NSF-CATE center at FIU is to foster a cross-disciplinary research and educational environment as a catalyst for our students to train and develop their creative thinking by bringing in synergy the fields of image and signal processing, human-computer interfaces, and neuroscience. In the merging of these technologies, we see a productive ground for the development of new methodologies and designs that (1) meet the impending needs in neuroscience as we elicit both the functional mapping of the brain, and the causality of key brain disorder focusing on epilepsy and Alzheimer's disease; and (2) can be used as assistive technology tools that address effectively the issue of "Universal Accessibility", focusing on persons with visual and motor disabilities.